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Applications of Magnetic Nanoparticles in Biomedicine

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Book cover Nanoscale Magnetic Materials and Applications

Abstract

In recent years, magnetic nanoparticles have played an increasing role in biomedical applications and have been the subject of extensive research investigations. Physical properties, including nanoparticle size, composition, and surface chemistry, vary widely and influence their biological and pharmacological properties and, ultimately, their clinical applications. Among different magnetic nanoparticles, superparamagnetic iron oxide nanoparticles (SPIOs) were found nontoxic and used as magnetic resonance imaging (MRI) contrast agents, in molecular and cellular imaging applications. SPIOs are used in detection of liver metastases, metastatic lymph nodes, and inflammatory and/or neural degenerative diseases. In addition, drug delivery via magnetic targeting, hyperthermia, and labeling/ tracking of stem cells have also been explored as potential therapeutic options.

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Abbreviations

Ab:

antibody

AG:

arabinogalactan

AOT:

dioctyl sulfosuccinate sodium salt

CCK:

cholecystokinin

α-CD:

α-cyclodextrin

CEA:

carcinoembryonic antigen

CLIO:

cross-linked iron oxide

CNS:

central nervous system

CT:

computed tomography

DMAP:

4-(dimethyl-amino) pyridine

DMSA:

meso-2,3-dimercaptosuccinic acid

DSPE-PEG:

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)]

EAE:

experimental autoimmune encephalomyelitis

Gd-BOPTA:

gadobenate dimeglumine

GI:

gastrointestinal tract

GSH:

glutathione

hCG:

human chorionic gonadotropin

HSA:

human serum albumin

IgG:

Immunoglobulin G

mAb:

monoclonal antibody

MDT:

magnetic drug targeting

MRI:

magnetic resonance imaging

MION:

monocrystalline iron oxide nanoparticles

MEIO:

magnetism-engineered iron oxide

MI:

myocardial infarction

Ms :

saturation magnetization

MSC:

mesenchymal stem cells

MPM:

malignant pleural mesothelioma

MPS:

mononuclear phagocytic system

MPM:

malignant pleural mesothelioma

OMP:

oral magnetic particles

PCL-b-PEG:

poly(ɛ-caprolactone)-b-poly(ethylene glycol)

PEG:

polyethylene glycols

PEO:

poly(ethylene oxide)

PLL:

poly(l-lysine)

PPO:

poly(propylene oxide)

PSA:

polysialic acids

RES:

reticuloendothelial system

RGD:

arginine–glycine–aspartic acid containing synthetic peptide

SC:

stem cells

SPIO:

superparamagnetic iron oxide

SSPIO:

standard superparamagnetic iron oxide

TAT:

transactivator of transcription peptide

TCL-SPION:

thermal cross-linked superparamagnetic iron oxide

USPIO:

ultra-small superparamagnetic iron oxide

VCAM-1:

vascular cell adhesion molecule-1

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Authors and Affiliations

  1. Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 75390, Dallas, TX, USA

    Carlos Bárcena, Amandeep K. Sra & Jinming Gao

  2. Department of Chemistry, University of Texas at Dallas, Richardson, 75080, Dallas, TX, USA

    Carlos Bárcena & Jinming Gao

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  2. Amandeep K. Sra
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Correspondence to Jinming Gao .

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  1. Dept. Physics, University of Texas, Arlington, Yates Street 502, Arlington, 76019, USA

    J. Ping Liu

  2. Center for Magnetic Recording Research, University of California, San Diego, Gilman Drive 9500, La Jolla, 92093-0401, USA

    Eric Fullerton

  3. Werkstoffforschung (IFW Dresden), Leibniz Institut für Festkörper- und, Helmholtzstr. 20, Dresden, 01069, Germany

    Oliver Gutfleisch

  4. Center for Materials Research &, University of Nebraska, Lincoln, Brace Laboratory 112, Lincoln, 68588-0113, USA

    D.J. Sellmyer

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Bárcena, C., Sra, A.K., Gao, J. (2009). Applications of Magnetic Nanoparticles in Biomedicine. In: Liu, J., Fullerton, E., Gutfleisch, O., Sellmyer, D. (eds) Nanoscale Magnetic Materials and Applications. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-85600-1_20

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