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Citrate Metabolism in Prostate and Other Cancers

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References

  • Baggetto, L. G. 1992. Deviant energetic metabolism of glycolytic cancer cells. Biochimie 74:959–974.

    Article  CAS  PubMed  Google Scholar 

  • Costello, L. C., and Franklin, R. B. 1989. Prostate epithelial cells utilize glucose and aspartate as the carbon sources for net citrate production. Prostate 15:335–342.

    Article  CAS  PubMed  Google Scholar 

  • Costello, L. C., and Franklin, R. B. 2001. The intermediary metabolism of the prostate: A key to understanding the pathogenesis and progression of prostate malignancy. Oncology 59:269–282.

    Article  Google Scholar 

  • Costello, L. C., and Franklin, R. B. 2002. Testosterone and prolactin regulation of metabolic genes and citrate metabolism of prostate epithelial cells. Horm Metabol Res 34:417–424.

    Article  CAS  Google Scholar 

  • Costello, L. C., and Franklin, R. B. 2005. “Why do tumor cells glycolyze?”: From glycolysis through citrate to lipogenesis. Mol Cell Biochem 280:1–8.

    Article  CAS  PubMed  Google Scholar 

  • Costello,L. C.,Franklin,and R. B.2006. The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: Connecting the dots. Mol Cancer 5:17.

    Article  PubMed  Google Scholar 

  • Costello, L. C., Franklin, R. B., and Stacey, R. 1976. Mitochondrial isocitrate dehydrogenase and isocitrate oxidation of rat ventral prostate. Enzyme 21:495–506.

    CAS  PubMed  Google Scholar 

  • Costello, L. C., Lao, L., and Franklin, R. B. 1993. Citrate modulation of high affinity aspartate transport in prostate epithelial cells. Cell Mol Biol 39:515–524.

    CAS  PubMed  Google Scholar 

  • Costello, L. C., Liu, Y., Franklin, R. B., and Kennedy, M. C. 1997. Zinc inhibition of mitochondrial aconitase and its importance in citrate metabolism of prostate epithelial cells. J Biol Chem 272:28875–28881.

    Article  CAS  PubMed  Google Scholar 

  • Costello, L. C., Franklin, R. B., and Narayan, P. 1999. Citrate in the diagnosis of prostate cancer. Prostate 15:237–245.

    Article  Google Scholar 

  • Costello, L. C., Guan, Z., Kukoyi, B., Feng, P., and Franklin, R. B. 2004. Terminal oxidation and the effects of zinc in prostate and liver mitochondria. Mitochondrion 4:331–338.

    Article  CAS  PubMed  Google Scholar 

  • Costello, L. C., Feng, P., and Franklin, R. B. 2005. Mitochondrial function, zinc, and intermediary metabolism relationships in normal prostate and prostate cancer. Mitochondrion 5:143–153.

    Article  CAS  PubMed  Google Scholar 

  • Feng, P., Liang, J. Y., Li, T. L., Guan, Z. X., Zou, J., Franklin, R. B., and Costello, L. C. 2000. Zinc induces mitochondria apoptogenesis in prostate cells. Mol Urol 4:31–36.

    CAS  PubMed  Google Scholar 

  • Feng, P., Li, T. L., Guan, Z. X., Franklin, R. B., and Costello, L. C. 2002. Direct effect of zinc on mitochondrial apoptogenesis in prostate cells. Prostate 52:311–318

    Article  CAS  PubMed  Google Scholar 

  • Franklin, R. B., and Costello, L. C. 2007. Zinc as an anti-tumor agent in prostate cancer and in other cancers. Arch Biochem Biophys 463:211–217.

    Article  CAS  PubMed  Google Scholar 

  • Franklin, R. B., Lao, L., and Costello, L. C. 1990. Evidence for two aspartate transport systems in prostate epithelial cells. Prostate 16:137–146.

    Article  CAS  PubMed  Google Scholar 

  • Franklin, R. B., Milon, B., Feng, P., and Costello, L. C. 2005. Zinc and zinc transporter in normal prostate function and the pathogenesis of prostate cancer. Frontiers Biosci 10:2230–2239.

    Article  CAS  Google Scholar 

  • Franklin, R. B., Zou, J., Yu, Z., and Costello, L. C. 2006. EAAC1 is expressed in rat and human prostate epithelial cells; functions as a high-affinityl.-aspartate transporter; and is regulated by prolactin and testosterone BMC Biochemistry 7:10.

    Article  PubMed  Google Scholar 

  • Guan, Z., Kukoyi, B., Feng, P., Kennedy, M. C., Franklin, R. B., Costello, L. C. 2003. Kinetic identification of a mitochondrial zinc uptake transport process in prostate cells. J Inorganic Biochem 97:199–206.

    Article  CAS  Google Scholar 

  • Halliday, K. R., Fenoglio-Preiser, C., and Sillerud, L. O. 1988. Differentiation of human tumors from nonmalignant tissue by natural-abundance 13C NMR spectroscopy. Magn Reson Med 7:384–411.

    Article  CAS  PubMed  Google Scholar 

  • Harkonen, P. L. 1981. Androgenic control of glycolysis, the pentose cycle and pyruvate dehydrogenase in the rat ventral prostate. J Steroid Biochem Mol Biol 14:1075–1084.

    CAS  Google Scholar 

  • Huggins, C. 1947. The prostatic secretion. Harvey Lect 42:148–193.

    CAS  Google Scholar 

  • Kline, E. E., Treat, E. G., Averna, T. A., Davis, M. S., Smith, A. Y., and Sillerud, L. O. 2006. Citrate concentrations in human seminal fluid and expressed prostatic fluid determined via 1H nuclear magnetic resonance spectroscopy outperform prostate specific antigen in prostate cancer detection. J Urol 176:2274–2279.

    Article  CAS  PubMed  Google Scholar 

  • Krezel, A., Hao, Q., and Maret, W. 2007. The zinc/thiolate redox biochemistry of metallothionein and the control of zinc ion fluctuations in cell signaling. Arch Biochem Biophys 463:188–200.

    Article  CAS  PubMed  Google Scholar 

  • Kurhanewicz, J., Swanson, M. G., Nelson, S. J. and Vigneron, D. B. 2002. Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancer. J Mag Reson Imag 16:451–463.

    Article  Google Scholar 

  • Lao, L., Franklin, R. B., and Costello, L. C. 1993. A high affinity L-aspartate transporter in prostate epithelial cells which is regulated by testosterone. Prostate 22:53–63.

    Article  CAS  PubMed  Google Scholar 

  • McKeechan, W. L. 1982. Glycolysis, glutaminolysis and cell proliferation. Cell Biol Int Rep 6:635–650.

    Article  Google Scholar 

  • Moreadith, R. W., and Lehninger, A. L. 1984. The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme. J Biol Chem 259:6215–6221.

    CAS  PubMed  Google Scholar 

  • Muntzing, J., Varkarakis, M. J., Saroff, J., and Murphy, G. P. 1975. Comparison and significance of respiration and glycolysis of prostatic tissue from various species. J Med Primatol 4:245–251.

    CAS  PubMed  Google Scholar 

  • Outten, C. E., and O’Halloran, T. V. 2001. Femtomolar sensitivity of metalloregulatory proteins controlling zinc homeostasis. Science 292:2488–2492.

    Article  CAS  PubMed  Google Scholar 

  • Parlo, R. A., and Coleman, P. S. 1984. Enhanced rate of citrate export from cholesterol-rich hepatoma mitochondria. J Biol Chem 259:997–10003.

    Google Scholar 

  • Parlo, R. A., and Coleman, P. S. 1986. Continuous pyruvate carbon flux to newly synthesized cholesterol and the suppressed evolution of pyruvate-generated CO2. in tumors: Further evidence for a persistent truncated Krebs cycle in hepatomas Biochim Biophys Acta 886:169–176.

    Article  CAS  PubMed  Google Scholar 

  • Pedersen, P. L. 1978. Tumor mitochondria and the bioenergetics of cancer cells. Prog Exp Tumor Res 22:190–274.

    CAS  PubMed  Google Scholar 

  • Racker, E., and Spector, M. 1981. Warburg effect revisited: Merger of biochemistry and molecular biology. Science 213:303–307.

    Article  CAS  PubMed  Google Scholar 

  • Schiebler, M. L., Schnall, M. D., Pollack, H. M., Lenkinski, R. E., Tomaszewski, J. E., Wein, A. J., Whittington, R., Rauschning, and W., Kressel, H. Y.1993. Current role of MR imaging in the staging of adenocarcinoma of the prostate. Radiology 189:339–352.

    CAS  PubMed  Google Scholar 

  • Singh, K. K., Desouki, M. M., Franklin, R. B., and Costello, L. C. 2006. Mitochondrial Aconitase and Citrate Metabolism in Malignant and Nonmalignant Human Prostate Tissues. Mol Cancer 5:14.

    Article  PubMed  Google Scholar 

  • Swinnen, J. V., Heemers, H., Heyns, W., and Verhoeven, G. 2002. Androgen regulation of lipogenesis. Adv Exp Med Biol 506:379–387.

    CAS  PubMed  Google Scholar 

  • Vallee, B. H., and Falchuk, K. H. 1993. Physiol Rev 73:79–118. The biochemical basis of zinc physiology.

    CAS  PubMed  Google Scholar 

  • Warburg, O., Wind, F., and Negelein, E. 1926. Uber den Stoffwechsel von Tumoren im Korper. Klin Woch 5:829–832.

    Article  CAS  Google Scholar 

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Acknowledgment The studies of LCC and RBF described in this review were supported in part by NIH grants CA71207, CA21097, CA79903, and CA93443.

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Authors and Affiliations

  1. Costello Department of Physiology and Endocrinology, Greenebaum Cancer Center, University of Maryland, Baltimore, MD, 21201, USA

    Renty B. Franklin

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  1. Renty B. Franklin
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  2. Leslie C. Costello
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Franklin, R.B., Costello, L.C. (2009). Citrate Metabolism in Prostate and Other Cancers. In: Mitochondria and Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84835-8_4

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