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References
Amo T, Brandt MD. 2007;Were effecient mitochondrial haplogroups selected during migration of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines. Biochem J 404:345–351
Aul C, Gattermann N, Schneider W. 1992;Age-related incidence and other epidemiological aspects of myelodysplastic syndromes. Br J Haematol 82:358–367
Baysal BE. 2003;On the association of succinate dehydrogenase mutations with hereditary paraganglioma. Trends Endocrinol Metab 14:453–459.
Baysal BE, Ferrell RE, Willett-Brozick JE, et al. 2000;Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 287:848–851.
Beckman JS, and Koppenol WH. 1996;Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 271:C1424–1437.
Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T, Taylor RW, Turnbull DM. 2006;High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet 38(5):515–517.
Berger G, Hunault-Berger M, Rachieru P, Fontenay-Roupie M, Baranger L, Ifrah N, Zandecki M. 2001;Increased apoptosis in mononucleated cells but not CD34+. cells in blastic forms of myelodysplastic syndromes The Hematol J 2:87–96
Bessis M. Living blood cells and their ultrastructure. 1973. Berlin: Springer.
Boultwood J, Fidler C, Mills KI, Frodsham PM, Kusec R, Gaiger A, Gale RE, Linch DC, Littlewood TJ, Moss PAH, Wainscoat JS. 1996;Amplification of mitochondrial DNA in acute myeloid leukaemia. Br J Haematol 95:426–431
Brierley EJ, Johnson MA, Lightowlers RN, James OFW, Turnbull DM. 1998;Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle. Ann Neurol 43:217–223
Bröker S, Meunier B, Rich P, Gattermann N, Hofhaus G. 1998;mtDNA mutations associated with sideroblastic anaemia cause a defect of mitochondrial cytochrome c oxidase. Eur J Biochem 258:132–138
Brown MD, Trounce IA, Jun AS, Allen JC, Wallace DC. 2000;Functional analysis of lymphoblast and cybrid mitochondria containing the 3460, 11778, or 14484 Leber’s hereditary optic neuropathy mitochondrial DNA mutation. J Biol Chem 275:39831–39836.
Buttgereit F, Brand MD. 1995;A hierarchy of ATP-consuming processes in mammalian cells. Biochem J 312:163–167
Canter JA, Kallianpur AR, Parl FF, Millikan RC. 2005;Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women. Cancer Res 65(17):8028–8033.
Carew JS, Zhou Y, Alibar M, Carew JD, Keating MJ, Huang P. 2003;Mitochondrial DNA mutations in primary leukemia cells after chemotherapy: clinical significance and therapeutic implications. Leukemia 17:1437–1447
Casas KA, Bykhovskaya Y, Mengesha E, Wang D, Yang H, Taylor K, Inbal A, Fischel-Ghodsian N. 2004;Gene responsible for mitochondrial myopathy and sideroblastic anemia (MSA) maps to chromosome 12q24.33. Am J Med Genet 127A:44–49
Casas KA, Fischel-Ghodsian N. 2004;Mitochondrial myopathy and sideroblastic anemia. Am J Med Genet 125A:201–204
Chalmers RM and Schapira AH. 1999;Clinical, biochemical and molecular genetic features of Leber’s hereditary optic neuropathy. Biochim Biophys Acta 1410:147–158.
Chinnery PF, Samuels DC. 1999;Relaxed replication of mtDNA: a model with implications for the expression of disease. Am J Hum Genet 64:1158–1165
Chinnery PF, Samuels DC, Elson JL, Turnbull DM. 2002;Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: is there a common mechanism? Lancet 360:1323–1325
Christiansen G, Christiansen C, Zeuthen J. 1983;Complex forms of mitochondrial DNA in human B cells transformed by Epstein–Barr virus. J Cancer Res Clin Oncol 105:13–19
Ciafaloni E, Ricci E, Shanske S, Moraes CT, Silvestri G, Hirano M, Simonetti S, Angelini C, Donati A, Garcia C, Martinuzzi A, Mosewich R, Servidei S, Zammarchi E, Bonilla E, DeVivo DC, Rowland LP, Schon EA, DiMauro S. 1992;MELAS: clinical features, biochemistry, and molecular genetics. Ann Neurol 31:391–398
Clayton DA, Smith CA. 1975;Complex mitochondrial DNA. Int Rev Exp Pathol 14:1–67
Clayton DA, Vinograd J. 1967;Circular dimer and catenate forms of mitochondrial DNA in human leukaemic leukocytes. Nature 216:652–657
Clayton DA, Vinograd J. 1969;Complex mitochondrial DNA in leukemic and normal human myeloid cells. Proc Natl Acad Sci USA 62:1077–1084
Coller HA, Khrapko K, Bodyak ND, Nekhaeva E, Herrero-Jimenez P, Thilly WG. 2001;High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection. Nat Genet 28:147–150
Coskun PE, Ruiz-Pesini E, Wallace DC. 2003;Control region mtDNA variants: Longevity, climatic adaptation, and a forensic conundrum. Proc Natl Acad Sci USA 100:2174–2176
Crisan D. 2000;Molecular mechanisms in myelodysplastic syndromes and implications for evolution to acute leukemias. Clin Lab Med 20:49–69, viii
Danielson SR, Wong A, Carelli V, Martinuzzi A, Schapira AH, Cortopassi GA. 2002;Cells bearing mutations causing Leber’s hereditary optic neuropathy are sensitized to Fas-Induced apoptosis. J Biol Chem 277:5810–5815.
de Grey AD. 1997;A proposed refinement of the mitochondrial free radical theory of ageing. Bioessays 19:161–166
Dick JE, Lapidot T. (2005) Biology of normal and acute myeloid leukemia stem cells. Int J Hematol 82(5):389–396. Review.
DiMauro S, Schon EA. 2003;Mitochondrial respiratory-chain diseases. N Engl J Med 348:2656–2668.
Donnellan R, Chetty R. 1998;Cyclin D1 and human neoplasia (). Mol Pathol 51(1):1–7.Review
Elson JL, Samuels DC, Turnbull DM, Chinnery PF. 2001;Random intracellular drift explains the clonal expansion of mitochondrial mutations with age. Am J Hum Genet 68:802–806
Elson JL, Turnbull JM, Taylor RW. 2007;Testing the adaptive selection of mitochondrial haplogroups: an experimental bioenergetics approach. Biochem J 404:e3–e35
Eng C, Kiuru M, Fernandez MJ, et al. 2003;A role for mitochondrial enzymes in inherited neoplasia and beyond. Nat Rev Cancer 3:193–202.
Firkin FC, Clark-Walker GD. 1979;Abnormal mitochondrial DNA in acute leukemia and lymphoma. Br J Haematol 43:201–206
Fliss MS, Usadel H, Cabalero OL, Wu L, Buta M, Eleff SM, Jen J, Sidransky D. 2000;Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science 287:2017–2019
Gattermann N. 2000;From sideroblastic anemia to the role of mitochondrial DNA mutations in myelodysplastic syndromes. Leuk Res 24:141–151.
Gattermann N, Aul C. 1997;Mitochondrial DNA amplification in AML: a hypothesis. Br J Haematol 97:242.
Gattermann N, Aul C, Schneider W. 1990;Two types of acquired idiopathic sideroblastic anaemia (AISA). Br J Haematol 74:45–52
Gattermann N, Berneburg M, Heinisch J, Aul C, Schneider W. 1995;Detection of the ageing-associated 5-Kb deletion of mitochondrial DNA in blood and bone marrow of hematologically normal adults. Absence of the deletion in clonal bone marrow disorders. Leukemia 9:1704–1710
Gattermann N, Retzlaff S, Wang Y-L, Berneburg M, Heinisch J, Wlaschek M, Aul C, Schneider W. 1996;A heteroplasmic point mutation of mitochondrial tRNALeu(CUN). in non-lymphoid cell lineages from a patient with acquired idiopathic sideroblastic anaemia Br J Haematol 93:845–855
Gattermann N, Retzlaff S, Wang Y-L, Hofhaus G, Heinisch J, Aul C, Schneider W. 1997;Heteroplasmic point mutations of mitochondrial DNA affecting subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia. Blood 90:4961–4972
Geiger H, van Zant G. 2002;The aging of lympho-hematopoietic stem cells. Nat Immunol 3:329–333
Germing U, Gattermann N, Aivado M, Hildebrandt B, Aul C. 2000;Two types of acquired idiopathic sideroblastic anaemia (AISA): a time-tested distinction. Br J Haematol 108:724–728
Goto Y-I, Horai S, Matsuoka T, Koga Y, Nihei K, Kobayashi M, Nonaka I. 1991;Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): a correlative study of the clinical features and mitochondrial DNA mutation. Neurology 42:545–550
Gutteridge JM. 1989;Iron and oxygen: a biologically damaging mixture. Acta Paediatr Scand Suppl 361:78–85
Habano W, Nakamura S, Sugai T. 1998;Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: evidence for mismatch repair systems in mitochondrial genome. Oncogene 17:1931–1937
Haddad JJ. 2002;Redox regulation of pro-inflammatory cytokines and IkappaB-alpha/NF-kappaB nuclear translocation and activation. Biochem Biophys Res Commun 296:847–856
Harris NL, Jaffe ES, Diebold J, et al. 1999;World Health Organisation classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the clinical advisory committee meeting—Airlie House, Virginia. J Clin Oncol 17:3835–3849
Hatfill S, Kirby R. 1994;Abnormal mitochondrial DNA length polymorphism in patients with the myelodysplastic syndrome. Blood 84:314a
He L, Luo L, Proctor SJ, Middleton PG, Blakely EL, Taylor RW. 2003;Turnbull DM. Somatic mitochondrial DNA mutations in adult-onset leukaemia. Leukemia 17:2487–2491.
Hofhaus G, Gattermann N. 1999;Mitochondria harbouring mutant mtDNA – a cuckoo in the nest? Biol Chem 380:871–877
Hofhaus G, Johns DR, Hurko O, Attardi G, Chomyn A. 1996;Respiration and growth defects in transmitochondrial cell lines carrying the 11778 mutation associated with Leber’s hereditary optic neuropathy. J Biol Chem 271:13155–13161.
Holme E, Tulinius MH, Larsson N-G, Oldfors A. 1995;Inheritance and expression of mitochondrial DNA point mutations. Biochim Biophys Acta 1271:249–252
Horton TM, Petros JA, Heddi A, Shoffner J, Kaufman AE, et al. 1996;Novel mitochondrial DNA deletion found in a renal cell carcinoma. Genes Chromosomes Cancer 15:95–101.
Howell N. 1998;Leber hereditary optic neuropathy: respiratory chain dysfunction and degeneration of the optic nerve. Vision Res 38:1495–1504
Inbal A, Avissar NSM, Kuritzky A, Schejter A, Ben-David E, Shanske S, Garty B-Z. 1995;Myopathy, lactic acidosis, and sideroblastic anemia: A new syndrome. Am J Med Genet 55:371–378
Ivanova R, Lepage V, Loste MN, Schachter F, Wijnen E, Busson M, Cayuela JM, Sigaux F, Charron D. 1998;Mitochondrial DNA sequence variation in human leukemic cells. Int J Cancer 76:495–498
Jeronimo C, Nomoto S, Caballero OL, Usadel H, Henrique R, Varzim G, Oliveira J, Lopes C, Fliss MS, Sidransky D. 2001;Mitochondrial mutations in early stage prostate cancer and bodily fluids. Oncogene 20:5195–5198
Johns DR, Neufeld MJ. 1993;Pitfalls in the molecular genetic diagnosis of Leber hereditary optic neuropathy (LHON). Am J Hum Genet 53:916–920.
Jones JB, Song JJ, Hempen PM, Parmigiani G, Hruban RH, Kern SE. 2001;Detection of mitochondrial DNA mutations in pancreatic cancer offers a ’mass”-ive advantage over detection of nuclear DNA mutations. Cancer Res 61:1299–1304
Kraytsberg Y, Nekhaeva E, Bodyak ND, Khrapko K. 2003;Mutation and intracellular clonal expansion of mitochondrial genomes: two synergistic components of the aging process? Mech Ageing Dev 124:49–53
Kroemer G, Reed JC. 2000;Mitochondrial control of cell death. Nat Med 6:513–519
Larsson NG, Holme E, Kristiansson B, Oldfors A, Tulinius M. 1991;Progressive increase of the mutated mitochondrial DNA fraction in Kearns-Sayre syndrome. Pediatr Res 28:131–133
Liang Y, Van Zant G, Szilvassy SJ. 2005;Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood 106:1479–1487
Linnartz B, Anglmayer R, Zanssen S. 2004;Comprehensive scanning of somatic mitochondrial DNA alterations in acute leukemia developing from myelodysplastic syndromes. Cancer Res 64:1966–1971.
Liu VW, Shi HH, Cheung AN, Chiu PM, Leung TW, Nagley P, Wong LC, Ngan HY. 2001;High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas. Cancer Res 61:5998–6001.
Liu SL, Lin X, Shi DY, Cheng J, Wu CQ, Zhang YD. 2002;Reactive oxygen species stimulate human hepatoma cell proliferation via cross-talk between PI3K/PKB and JNK signaling pathways. Arch Biochem Biophys 406:173–182
Luft R. 1994;The development of mitochondrial medicine. Proc Natl Acad Sci USA 91:8731–8738.
Marley SB, Lewis JL, Davidson RJ, Roberts IAG, Dokal I, Goldman JM, Gordon MY. 1999;Evidence for a continuous decline in haematopoietic cell function from birth: application to evaluating bone marrow failure in children. Br J Haematol 106:162–166
McShane MA, Hammans SR, Sweeney M, Holt IJ, Beattie TJ, Brett EM, Harding AE. 1991;Pearson syndrome and mitochondrial encephalomyopathy in a patient with a deletion of mtDNA. Am J Hum Genet 48:39–42
Miguel A, Hernández-Yago J, Knecht E, Renau-Piqueras J. 1982;A comparative study of complex mitochondrial DNA in human lymphocytes transformed by Epstein–Barr virus and PHA. Acta Haematologica 68:96–104
Modica-Napolitano JS, Kulawiec M, Singh KK. 2007;Mitochondria and human cancer (). Curr Mol Med 7(1):121–31.Review
Morrison SJ, Wandycz AM, Akashi K, Globerson A, Weissman IL. 1996;The aging of hematopoietic stem cells. Nat Med 2:1011–1016
Muller-Hocker J. 1992;Random cytochrome-C-oxidase deficiency of oxyphil cell nodules in the parathyroid gland. A mitochondrial cytopathy related to cell ageing? Pathol Res Pract 188:701–706.
Murdock DG, Christiacos NC, Wallace DC. 2000;The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method. Nucleic Acids Res 28:4350–4355
Nekhaeva E, Bodyak ND, Kraytsberg Y, McGrath SB, Van Orsouw NJ, Pluzhnikov A, Wei JY, Vijg J, Khrapko K. 2002;Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc Natl Acad Sci USA 99:5521–5526
Nelson I, Bonne G, Degoul F, Marsac C, Ponsot G, Lestienne P. 1992;Kearns–Sayre syndrome with sideroblastic anemia: molecular investigations. Neuropediatrics 23:199–205
Nikoselainen E, Asola M, Kalimo H, Savontaus ML, Majander A. 1992;Benzodiazepine sensititvity in Leber’s hereditary optic neuropathy (letter). Lancet 340:1223–1224
Okochi O, Hibi K, Uemura T, Inoue S, Takeda S, Kaneko T, Nakao A. 2002;Detection of mitochondrial DNA alterations in the serum of hepatocellular carcinoma patients. Clin Cancer Res 8:2875–2878
Parker JE, Fishlock KL, Mijovic J, Czepulkowski B, Pagliuca A, Mufti GJ. 1998;‘Low-risk’ myelodysplastic syndrome is associated with excessive apoptosis and an increased ratio of pro- versus anti-apoptotic bcl-2-related proteins. Br J Haematol 103:1075–1082
Parrella P, Xiao Y, Fliss M, Sanchez-Cespedes M, Mazzarelli P, Rinaldi M, Nicol T, Gabrielson E, Cuomo C, Cohen D, Pandit S, Spencer M, Rabitti C, Fazio VM, Sidransky D. 2001;Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates. Cancer Res 61:7623–7626
Pearson HA, Lobel JS, Kocoshis SA, Naiman JL, Windmiller J, Lammi AT, Hoffman R, Marsh JC. 1979;A new syndrome of refractory sideroblastic anemia with vacuolization of marrow precursors and exocrine pancreatic dysfunction. J Pediatr 95:976–984
Penta JS, Johnson FM, Wachsman JT, Copeland WC. 2001;Mitochondrial DNA in human malignancy. Mutat Res 488:119–133
Petros JA, Baumann AK, Ruiz-Pesini E, Amin MB, Sun CQ, Hall J, Lim S, Issa MM, Flanders WD, Hosseini SH, Marshall FF, Wallace DC. mtDNA mutations increase tumorigenicity in prostate cancer. Proc Natl Acad Sci USA 102(3):719–724.
Polyak K, Li Y, Zhu H, Lengauer C, Willson JKV, Markowitz SD, Trush MA, Kinzler KW, Vogelstein B. 1998;Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet 20:291–293
Poulton J, Morten K. 1993;Noninvasive diagnosis of the MELAS syndrome from blood DNA. Ann Neurol 34:116
Puigserver P, Spiegelmann BM Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coacti1 vator and metabolic regulator. 2003;24(1):78-90
Rahman S, Poulton J, Marchington D, Suomalainen A. 2001;Decrease of 3243 A→G mtDNA mutation from blood in MELAS syndrome: a longitudinal study. Am J Hum Genet 68:238–240
Rawles JM, Weller RO. 1974;Familial association of metabolic myopathy, lactic acidosis, and sideroblastic anemia. Am J Med 56:891–897
Rötig A, Cormier V, Blanche S, Bonnefont J-P, Ledeist F, Romero N, Schmitz J, Rustin P, Fischer A, Saudubray J-M, Munnich A. 1990;Pearson’s marrow-pancreas syndrome. A multisystem mitochondrial disorder in infancy. J Clin Invest 86:1601–1608
Rötig A, Cormier V, Koll F, Mize CE, Saudubray J-M, Veerman A, Pearson HA, Munnich A. 1991;Site-specific deletions of the mitochondrial genome in the Pearson marrow-pancreas syndrome. Genomics 10:502–504
Rustin P, Rotig A. 2002;Inborn errors of complex II–unusual human mitochondrial diseases. Biochim Biophys Acta 1553:117–122.
Sakamaki T, Casimiro MC, Ju X, Quong AA, Katiyar S, Liu M, Jiao X, Li A, Zhang X, Lu Y, Wang C, Byers S, Nicholson R, Link T, Shemluck M, Yang J, Fricke ST, Novikoff PM, Papanikolaou A, Arnold A, Albanese C, Pestell R. 2006;Cyclin D1 determines mitochondrial function in vivo. Mol Cell Biol 26(14):54495469
Santoro A, Salvioli S, Raule N, Capri M, Sevini F, Valensin S, Monti D, Bellizzi D, Passarino G, Rose G, De Benedictis G, Franceschi C. 2006;Mitochondrial DNA involvement in human longevity. Biochim Biophys Acta 757(9–10):1388–1399.
Schumacher HR, Szekely IE, Patel SB, Fisher DR. 1974;Leukemic mitochondria. I. Acute myeloblastic leukemia. Am J Pathol 74:71–82
Selak MA, Armour SM, MacKenzie ED, et al. 2005;Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell 7:77–85.
Shin MG, Kajigaya S, Levin BC, Young NS. 2003Mitochondrial DNA mutations in patients with myelodysplastic syndromes. Blood ;101:3118–3125
Shin MG, Kajigaya S, Tarnowka M, McCoy Jr JP, Levin BC, Young NS. 2004;Mitochondrial DNA sequence heterogeneity in circulating normal human CD34 cells and granulocytes. Blood 103(12):4466–4471
Shoubridge EA, Karpati G, Hastings KEM. 1990;Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease. Cell 62:43–49
Singh G, Lott MT, Wallace DC. 1989;A mitochondrial mutation as a cause of Leber’s hereditary optic neuropathy. N Engl J Med 36:1300–1305
Singh KK, Kulawiec M, Still I, Desouki MM, Geradts J, Matsui S. 2005;Inter-genomic cross talk between mitochondria and the nucleus plays an important role intumorigenesis. Gene 354:140–146.
Singh KK 2006;Mitochondria damage checkpoint, aging, and cancer (). Ann NY Acad Sci 1067:182–190.Review
Taylor RW, Barron MJ, Borthwick GM, Gospel A, Chinnery PF, Samuels DC, Taylor GA, Plusa SM, Needham SM, Greaves LC, Kirkwood TBL, Turnbull DM. 2003;Mitochondrial DNA mutations in human colonic crypt stem cells. J Clin Invest 112:1351–1360
Tehranchi R, Fadeel B, Forsblom A-M, Christensson B, Zhivotovsky B, Hellström-Lindberg E. 2001;Evidence for a role of mitochondrial signaling in apoptosis in low-risk myelodysplastic syndromes. Blood 98:730a
Verma M, Naviaux RK, Tanaka M, Kumar D, Franceschi C, Singh KK. 2007;Meeting report: mitochondrial DNA and cancer epidemiology. Cancer Res 67(2):437–439
Wallace DC. 1989;Mitochondrial DNA mutations and neuromuscular disease. Trends Genet 5:9–13
Wallace DC. 1992;Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 256:628–632.
Wallace DC. 1999;Mitochondrial diseases in man and mouse. Science 283:1482–1488
Wallace DC. 2005;A mitochondrial paradigm of Metabolic and degenerative disease, aging, and cancer. Annu Rev Genet 39:359–407
Wang Y-L, Choi H-K, Heinisch J, Aul C, Gattermann N. 1999;The MERRF mutation of mitochondrial DNA in the bone marrow of a patient with acquired idiopathic sideroblastic anemia. Am J Hematol 60:83–84
Warburg O. 1956;On the origin of cancer cells. Science. 123:309–314
Wickramasinghe SN, Chalmers DG, Cooper EH. 1968;A study of ineffective erythropoiesis in sideroblastic anaemia and erythraemic myelosis. Cell Tissue Kinet 1:43–50
Wickramasinghe SN, Hughes M. 1978;Capacity of ringed sideroblasts to synthesize nucleic acids and protein in patients with primary acquired sideroblastic anaemia. Br J Haematol 38:345–352
Wolvetang EJ, Johnson KL, Krauer K, Ralph S, Linnane AW. 1994;Mitochondrial respiratory chain inhibitors induce apoptosis. FEBS Lett 339:40–44
Yao YG, Ellison FM, McCoy JP, Chen J, Young NS. 2007;Age-dependant accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background. Hum Mol Gen 16:286–294
Zanssen S, and Buse G. 2003;Successful chemotherapy in a male patient with malignant lymphoma and Leber’s hereditary optic neuropathy (LHON). Am J Hematol 72:263–266
Zanssen S, Gunawan B, Fuzesi L, et al. 2004;Renal oncocytomas with rearrangements involving 11q13 contain breakpoints near CCND1. Cancer Genet Cytogenet 149:120–124.
Zanssen, and Schon (2005) Mitochondrial DNA mutations in cancer. PLOS Med 11:e401
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Zanssen, S. (2009). Mitochondria in Hematology. In: Mitochondria and Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84835-8_10
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