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Effect of Cancer on Platelets

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Coagulation in Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 148))

Platelets play an essential role in hemostasis, the arrest of bleeding. In response to vascular injury, platelets become adherent and undergo activation and aggregation. The formation of platelet plug occurs simultaneously with activation of coagulation leading to fibrin formation. Platelet function also contributes to pathologic thrombus formation leading to vascular occlusion often in the context of underlying vascular disease, which is a leading cause of morbidity and mortality. Other less well appreciated functions of platelets include a vascular maintenance function, regulation of angiogenesis, as well as putative roles in inflammation and immunity. Platelets are now linked to diverse physiologic and pathologic processes including wound healing and tissue regeneration, response to microbial infection, inflammatory diseases, atherogenesis, tumorigenesis and metastasis.

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  1. Department of Medicine/Hematology, New York University School of Medicine, 550 First Ave, New York, NY 10016

    David L. Green

  2. Dept of Medicine, New York Univ Medi Ctr, 550 First Ave, Room TH 439, New York, NY 10016-6481

    Simon Karpatkin

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    Green, D.L., Karpatkin, S. (2009). Effect of Cancer on Platelets. In: Kwaan, H., Green, D. (eds) Coagulation in Cancer. Cancer Treatment and Research, vol 148. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-79962-9_2

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