Date: 29 Dec 2011

Recreating Synaptic Noise Using Dynamic-Clamp

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Abstract

This chapter will cover one of the most promising and elegant approach for studying the effect of synaptic noise on neurons: the dynamic-clamp injection of artificial conductance-based synaptic noise.We start by an introduction to the dynamic-clamp technique, and we next describe the “re-creation” of in vivo-like activity states in neurons maintained in vitro. We then overview the consequences of synaptic noise on the integrative properties of neurons, as found by dynamic-clamp experiments.