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The Peritoneal Microcirculation in Peritoneal Dialysis

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Nolph and Gokal's Textbook of Peritoneal Dialysis

The peritoneal microcirculation is an intricate microvascular network through which physiological interactions occur between the systemic vasculature and the peritoneal cavity. In peritoneal dialysis these dynamic interactions are of paramount importance in maintaining effective dialysis. The peritoneal microcirculation participates in numerous physiological functions including solute transfer and exchange, regulation of fluid dynamics and ultrafiltration, delivery of nutrients and hormones, delivery of leukocytes to areas of inflammation, and distribution of drugs. Physiological and pathophysiological changes, as well as the process of peritoneal dialysis, may affect many of these microvascular functions. The emphasis of this chapter will be to review available information regarding the peritoneal microcirculation and to integrate this information into a general functional knowledge as it relates to peritoneal dialysis. The chapter will examine: 1) the functional anatomy and blood supply of the peritoneum, 2) components of the peritoneal microvascular network, 3) peritoneal microvascular hemodynamics and the effects of vasoactive agents on the microcirculation, and 4) inflammation in the peritoneal microcirculation with emphasis on leukocyte-endothelial interactions.

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Authors and Affiliations

  1. AZ Sint-Jan AV, Dept. of Internal Medicine, Brugge, Belgium

    A. S. De Vriese

  2. LSU Health Sciences Center, Shreveport, Louisiana

    R. White

  3. Department of Molecular & Cellular Physiology, LSU Health Sciences Center, Shreveport, Louisiana

    D.N. Granger

  4. University Hospital Ghent, De Pintelaan 185, Ghent, Belgium

    N.H. Lameire

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  1. A. S. De Vriese
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  2. R. White
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  3. D.N. Granger
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  4. N.H. Lameire
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Correspondence to A. S. De Vriese .

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Editors and Affiliations

  1. School of Medicine Department of Medicine Division of Nephrology, MA436 Health Sciences Center, Columbia, MO 65212, USA

    Ramesh Khanna

  2. Academic Medical Center Dept. Medicine, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

    Raymond T. Krediet

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De Vriese, A.S., White, R., Granger, D., Lameire, N. (2009). The Peritoneal Microcirculation in Peritoneal Dialysis. In: Khanna, R., Krediet, R.T. (eds) Nolph and Gokal's Textbook of Peritoneal Dialysis. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-78940-8_4

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