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Genomic Imprinting pp 41–61Cite as

Imprinted Genes, Postnatal Adaptations and Enduring Effects on Energy Homeostasis

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 626))

Abstract

The effects of imprinted genes on fetal growth and development have been firmly established. By and large, their roles conform to a conflict over provision of limited maternal resources to offspring, such that paternally expressed imprinted genes in offspring generally promote growth of the fetus, while maternally expressed imprinted genes tend to restrict it. It is comparatively recently that the important effects of imprinted genes in postnatal physiology have begun to be demonstrated, although a similar conflict may apply. In this chapter, we shall review some of the genetic evidence for imprinted effects on obesity, consider the action of selected imprinted genes in the central and peripheral control of energy homeostasis and look in detail at the intriguing effects of imprinting at the Gnas locus. Finally, we shall discuss whether these observations fit expectations of the prevailing theory for the existence of imprinting in mammals and go on to consider imprinted genes as targets for developmental programming.

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Authors and Affiliations

  1. Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, CB22 3AT, UK

    Margalida Frontera, Benjamin Dickins & Gavin Kelsey

  2. Physiological Laboratory School of Biomedical Sciences, University of Liverpool, Liverpool, UK

    Antonius Plagge

Authors
  1. Margalida Frontera
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  2. Benjamin Dickins
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  3. Antonius Plagge
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  4. Gavin Kelsey
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Corresponding author

Correspondence to Gavin Kelsey .

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Editors and Affiliations

  1. Santa Fe Institute, Santa Fe, New Mexico, USA

    Jon F. Wilkins Ph.D.

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Frontera, M., Dickins, B., Plagge, A., Kelsey, G. (2008). Imprinted Genes, Postnatal Adaptations and Enduring Effects on Energy Homeostasis. In: Wilkins, J.F. (eds) Genomic Imprinting. Advances in Experimental Medicine and Biology, vol 626. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77576-0_4

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