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Perioperative Cardioprotection

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Book cover Intensive Care Medicine

Abstract

The perioperative period induces large, unpredictable and unphysiological changes in sympathetic tone, cardiovascular performance, coagulation and inflammatory response (to name just a few). These changes induce, in turn, unpredictable alterations in coronary plaque morphology, function, and progression. Simultaneous perioperative alterations in homeostasis and coronary plaque characteristics may trigger a mismatch of myocardial oxygen supply and demand by numerous mechanisms. If not alleviated in time, this will ultimately result in myocardial infarction, irrespective of its etiology (morphological, hemodynamic, inflammatory, or coagulation-induced). Thus, not surprisingly, in patients with coronary artery disease, the incidence of perioperative cardiac morbidity and mortality remains high and is associated with adverse outcome [1]. Consequently, the quest for perioperative cardioprotective strategies continues.

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Author information

Authors and Affiliations

  1. Department of Anesthesiology, University Hospital Hugstetter Str., 5579106, Freiburg, Germany

    H. -J. Priebe

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  1. H. -J. Priebe
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Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Université libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium

    Jean-Louis Vincent MD, PhD, FCCM, FCCP (Head) (Head)

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Priebe, H.J. (2008). Perioperative Cardioprotection. In: Vincent, JL. (eds) Intensive Care Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77383-4_10

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  • DOI: https://doi.org/10.1007/978-0-387-77383-4_10

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-77382-7

  • Online ISBN: 978-0-387-77383-4

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