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Ca2+ Signaling in Dendritic Spines

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Structural And Functional Organization Of The Synapse

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Abstract

Dendritic spines are neuronal microcompartments that are diffusionally isolated from their parent dendrites and neighboring spines. Optical studies of spine Ca2+ dynamics have revealed the Ca2+ sources and Ca2+ clearance mechanisms under a variety of experimental conditions and in diverse experimental systems. Here we review our understanding of Ca2+ signaling in spines, point out gaps in our knowledge, and discuss the limits of the existing experimental techniques.

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Authors and Affiliations

  1. Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA

    Bernardo L. Sabatini

  2. Janelia Farm Research Campus, HHMI, 19700 Helix Drive, Ashburn, VA 20147, USA

    Karel Svoboda

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  1. Bernardo L. Sabatini
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  2. Karel Svoboda
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Editors and Affiliations

  1. Department of Pharmacology 2-512 BSB, University of Iowa, Iowa City, IA 52242

    Johannes W. Hell

  2. Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710

    Michael D. Ehlers

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Sabatini, B.L., Svoboda, K. (2008). Ca2+ Signaling in Dendritic Spines. In: Hell, J.W., Ehlers, M.D. (eds) Structural And Functional Organization Of The Synapse. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-77232-5_15

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