The immune system plays a critical role in CNS disorders and spinal cord injury (SCI). Primary trauma to the adult mammalian spinal cord is immediately followed by secondary degeneration in which the inflammatory response is thought to be detrimental. This inflammatory response is mediated by small, chemotropic cytokines, called chemokines, which are secreted by a variety of cell types in the CNS including neurons, glia, and vascular cells. Here, we review studies which provide insight into the functional role of chemokines in neuroinflammation and disease, with an emphasis on SCI. More specifically, this review emphasizes studies which indicate that ablation of the T cell chemotactic CXC chemokine ligand 10 (CXCL10) results in diminished neuropathology associated with decreased immune cell infiltration into the CNS. Importantly, these findings reveal that targeting chemokines such as CXCL10 may offer a powerful therapeutic approach for the treatment of neuroinflammatory diseases.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer
About this chapter
Cite this chapter
Hatch, M.N., Keirstead, H.S. (2008). Chemokines and Spinal Cord Injury. In: Lane, T.E., Carson, M., Bergmann, C., Wyss-Coray, T. (eds) Central Nervous System Diseases and Inflammation. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-73894-9_11
Download citation
DOI: https://doi.org/10.1007/978-0-387-73894-9_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-73893-2
Online ISBN: 978-0-387-73894-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)