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To the Nucleus with Proteomics

  • Chapter
Transcriptional Regulation by Neuronal Activity

Abstract

In this chapter we review proteomic studies performed on purified postsynaptic density (PSD) fractions and analyze what their results reveal about nuclear signaling. Overall, these studies show that PSDs are similar to the cytoplasmic protein complexes found at other intercellular junctions. We find that PSDs contain numerous calmodulin (CAM)-associated transcriptional coactivators, nucleocytoplasmic shuttling proteins that bind RNA and potential splicing factors. Moreover, in conjunction with bioinformatics, we identify novel nucleocytoplasmic shuttling proteins at synapses. These results strongly suggest that control of the spatial distribution of synapse-associated nuclear factors regulates nuclear function.

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Authors
  1. Bryen A. Jordan
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  2. Edward B. Ziff
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  1. Laboratory of Neurobiology, Synaptic & Developmental Plasticity Group NIEHS/NIH, Research Triangle Park, NC 27709, USA

    Serena M. Dudek

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Jordan, B.A., Ziff, E.B. (2008). To the Nucleus with Proteomics. In: Dudek, S.M. (eds) Transcriptional Regulation by Neuronal Activity. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-73609-9_2

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