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Nanoparticles in Biomedical Imaging pp 91–140Cite as

(Super)paramagnetic Nanoparticles: Applications in Noninvasive MR Imaging of Stem Cell Transfer

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Part of the book series: Fundamental Biomedical Technologies ((FBMT,volume 102))

Abstract

Common techniques to monitor muscle stem cell transplants typically rely on ex vivo genetic modification to allow expression of reporter genes. Specific reporter genes allow for graft identification during post-mortem analysis. The use of these invasive techniques makes even simple and practical questions difficult and labor intensive to answer. The design and improvement of the stem cell-based therapies will be greatly facilitated by the development of sensitive, noninvasive, and nondestructive techniques for tracking stem cells following implantation or infusion. MR offers such an opportunity, due to its ability to obtain high-resolution 3D images repeatedly and noninasively. Reliable tracking by MR imaging can be achieved by labeling cells with (super)paramagnetic nanoparticles. In this chapter, we discuss recent advances in the development and applications of (super)paramagnetic nanoparticles for in vivo cell tracking and targeting.

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Authors
  1. Glenn A. Walter
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  2. Swadeshmukul Santra
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  3. Bijoy Thattaliyath
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  4. Samuel C. Grant
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Editor information

Editors and Affiliations

  1. Department of Radiology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, 21205

    Jeff W.M. Bulte

  2. Institute of Psychiatry King’s College London, Center for the Cellular Basis of Behaviour, 125 Coldharbour Lane, London SE5 9NU, United Kingdom

    Michel M.J. Modo

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© 2008 Springer Science+Business Media, LLC

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Walter, G.A., Santra, S., Thattaliyath, B., Grant, S.C. (2008). (Super)paramagnetic Nanoparticles: Applications in Noninvasive MR Imaging of Stem Cell Transfer. In: Bulte, J.W., Modo, M.M. (eds) Nanoparticles in Biomedical Imaging. Fundamental Biomedical Technologies, vol 102. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72027-2_6

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