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Treatment of Late-Life Generalized Anxiety Disorder in Primary Care Settings

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Late-life anxiety disorders are twice as prevalent as mood disorders and 4–8 times more prevalent than major depressive episodes (Regier et al., 1988; Weissman et al., 1985). Generalized Anxiety Disorder (GAD) is second only to specific phobias in prevalence among older adults (Krasucki, Howard, & Mann, 1999). Furthermore, the most common anxiety disorder within the primary care setting is GAD (Wittchen et al., 2002), with prevalence estimates ranging from 2.8 to 11.2% (Ansseau, Fischler, Dierick, Mignon, & Leyman, 2005; Roy-Byrne & Wagner, 2004; Tolin, Robison, Gaztambide, & Blank, 2005). Among community samples of older adults, GAD is associated with poor quality of life (Wetherell, Gatz, & Craske, 2003), increased comorbidity (Krasucki, Howard, & Mann, 1998), and increased service use (Stanley, Roberts, Bourland, & Novy, 2001). In primary care settings, GAD in later life is associated with increased worry, depression, and sleep difficulties, as well as decreased quality of life and reduced perceptions of general health, mental health, and vitality (Stanley et al., 2003). GAD in older adults is also associated with greater physical disability (Astrom, 1996). Because older adults tend to somaticize psychiatric problems (Lenze et al., 2005) and because of the overlap between GAD, depression, and comorbid medical problems, GAD can be difficult to diagnose in older adults.

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References

  • Alexopoulos, G. S., Raue, P., & Arean, P. (2003). Problem-solving therapy versus supportive therapy in geriatric major depression with executive dysfunction. American Journal of Geriatric Psychiatry, 11, 46–52.

    PubMed  Google Scholar 

  • Ansseau, M., Fischler, B., Dierick, M., Mignon, A., & Leyman, S. (2005). Prevalence and impact of generalized anxiety disorder and major depression in primary care in Belgium and Luxemburg: the GADIS study. European Psychiatry, 20, 229–235.

    Article  PubMed  Google Scholar 

  • Arean, P. A., Alvidrez, J., Barrera, A., Robinson, G. S., & Hicks, S. (2002). Would older medical patients use psychological services? Gerontologist, 42, 392–398.

    PubMed  Google Scholar 

  • Astrom, M. (1996). Generalized anxiety disorder in stroke patients. A 3-year longitudinal study. Stroke, 27, 270–275.

    PubMed  Google Scholar 

  • Ayalon, L., Arean, P. A., & Alvidrez, J. (2005). Adherence to antidepressant medications in black and Latino elderly patients. American Journal of Geriatric Psychiatry, 13, 572–580.

    PubMed  Google Scholar 

  • Ayers, C. R., Sorrell, J. T., Thorp, S. R., & Wetherell, J. L. (in press). Evidence-based treatments for late-life anxiety. Psychology and Aging, 22, 52–55.

    Google Scholar 

  • Bartels, S. J., Coakley, E. H., Zubritsky, C., Ware, J. H., Miles, K. M., Arean, P. A., et al. (2004). Improving access to geriatric mental health services: A randomized trial comparing treatment engagement with integrated versus enhanced referral care for depression, anxiety, and at-risk alcohol use. American Journal of Psychiatry, 161, 1455–1462.

    Article  PubMed  Google Scholar 

  • Brenes, G. A. (2007, March). Acceptability of bibliotherapy with telephone contact as a treatment. Paper presented at the annual meeting of the Anxiety Disorders Association of America, St. Louis, MO.

    Google Scholar 

  • Brown, C., Battista, D. R., Bruehlman, R., Sereika, S. S., Thase, M. E., & Dunbar-Jacob, J. (2005). Beliefs about antidepressant medications in primary care patients: Relationship to self-reported adherence. Medical Care, 43, 1203–1207.

    Article  PubMed  Google Scholar 

  • Brown, T. A., DiNardo, P. A., & Barlow, D. H. (1994). Anxiety disorders interview schedule for DSM IV. Albany, NY: Graywinds.

    Google Scholar 

  • Chorpita, B. F., Taylor, A. A., Francis, S. E., Moffitt, C., & Austin, A. A. (2004). Efficacy of modular cognitive behavior therapy for childhood anxiety disorders. Behavior Therapy, 35, 263–287.

    Article  Google Scholar 

  • Craske, M. G., Roy-Byrne, P., Stein, M. B., Sherbourne, C. D., Bystritsky, A., Katon, W., et al. (2002). Treating panic disorder in primary care: A collaborative care intervention. General Hospital Psychiatry, 24, 148–155.

    Article  PubMed  Google Scholar 

  • First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (2002). Structured clinical interview for DSM-IV-TR axis I disorders, research version, patient edition (SCID-I/P). New York: Biometrics Research, New York State Psychiatric Institute.

    Google Scholar 

  • Gallo, J. J., Marino, S., Ford, D., & Anthony, J. C. (1995). Filters on the pathway to mental health care II: Sociodemographic factors. Psychological Medicine, 25, S79–S83.

    Article  Google Scholar 

  • Gum, A. M., Arean, P. A., Hunkeler, E., Tang, L., Katon, W., Hitchcock, P., et al. (2006). Depression treatment preferences in older primary care patients. Gerontologist, 46, 14–22.

    PubMed  Google Scholar 

  • Henin, A., Otto, M. W., & Reilly-Harrington, N. A. (2001). Introducing flexibility in manualized treatments: Application of recommended strategies to the cognitive-behavioral treatment of bipolar disorder. Cognitive and Behavioral Practice, 8, 317–327.

    Article  Google Scholar 

  • Hopko, D. R., Stanley, M. A., Reas, D. L., Wetherell, J. L., Beck, J. G., Novy, D. M., et al. (2003). Assessing worry in older adults: Confirmatory factor analysis of the Penn State Worry Questionnaire and psychometric properties of an abbreviated model. Psychological Assessment, 15, 173–183.

    Article  PubMed  Google Scholar 

  • Horne, R., Weinman, J., & Hankins, M. (1999). The beliefs about medicines questionnaire: The development and evaluation of a new method of assessing the cognitive representation of medication. Psychology and Health, 14, 1–24.

    Article  Google Scholar 

  • Kirmayer, L. J. (2001). Cultural variations in the clinical presentation of depression and anxiety: Implications for diagnosis and treatment. Journal of Clinical Psychiatry, 62, 22–28.

    PubMed  Google Scholar 

  • Klap, R., Unroe, K. T., & Unutzer, J. (2003). Caring for mental illness in the United States: A focus on older adults. American Journal of Geriatric Psychiatry, 11, 517–524.

    PubMed  Google Scholar 

  • Krasucki, C., Howard, R., & Mann, A. (1998). The relationship between anxiety disorders and age. International Journal of Geriatric Psychiatry, 13, 79–99.

    Article  PubMed  Google Scholar 

  • Krasucki, C., Howard, R., & Mann, A. (1999). Anxiety and its treatment in the elderly. International Psychogeriatrics, 11, 25–45.

    Article  PubMed  Google Scholar 

  • Kraus, C. A., Kunik, M., Rhoades, H., Novy, D. M., Wilson, N., & Stanley, M. A. (2005). Cross cultural differences in older adults with GAD. To be presented at the 39th Annual Convention of the Association for Advancement of Behavior Therapy, Washington, DC, November.

    Google Scholar 

  • Kunik, M. E., Roundy, K., Veazey, C., Souchek, J., Richardson, P., Wray, N. P., et al. (2005). Surprisingly high prevalence of anxiety and depression in chronic breathing disorders. Chest, 127, 1205–1211.

    Article  PubMed  Google Scholar 

  • Ladouceur, R., Leger, E., Dugas, M., & Freeston, M. H. (2004). Cognitive-behavioral treatment of generalized anxiety disorder (GAD) for older adults. International Psychogeriatrics, 16, 195–207.

    Article  PubMed  Google Scholar 

  • Landreville, P., Landry, J., Baillargeon, L., Guerette, A., & Matteau, E. (2001). Older adults’ acceptance of psychological and pharmacological treatments for depression. Journal of Gerontology B: Psychological Science and Social Science, 56, 285–291.

    Google Scholar 

  • Lenze, E. J., Karp, J. F., Mulsant, B. H., Blank, S., Shear, M. K., Houck, P. R., et al. (2005). Somatic symptoms in late-life anxiety: treatment issues. Journal of Geriatric Psychiatry and Neurology, 18, 89–96.

    Article  PubMed  Google Scholar 

  • Levkoff, S. E., Chen, H., Coakley, E., Herr, E. C., Oslin, D. W., Katz, I., et al. (2004). Design and sample characteristics of the PRISM-E multisite randomized trial to improve behavioral health care for the elderly. Journal of Aging and Health, 16, 3–27.

    Article  PubMed  Google Scholar 

  • Mickus, M., Colenda, C. C., & Hogan, A. J. (2000). Knowledge of mental health benefits and preferences for type of mental health providers among the general public. Psychiatric Services, 51, 199–202.

    Article  PubMed  Google Scholar 

  • Mohr, D. C., Hart, S. L., Julian, L., Catledge, C., Honos-Webb, L., Vella, L., et al. (2005). Telephone-administered psychotherapy for depression. Archives of General Psychiatry, 62, 1007–1014.

    Article  PubMed  Google Scholar 

  • Ormel, J., Kempen, G. I., Penninx, B. W., Brilman, E. I., Beekman, A. T., & van Sonderen, E. (1997). Chronic medical conditions and mental health in older people: disability and psychosocial resources mediate specific mental health effects. Psychological Medicine, 27, 1065–1077.

    Article  PubMed  Google Scholar 

  • Pearson, J. L. (1998). Summary of a National Institute of Mental Health workshop on late-life anxiety. Psychopharmacology Bulletin, 34, 127–130.

    PubMed  Google Scholar 

  • Regier, D. A., Boyd, J. H., Burke, J. D., Jr., Rae, D. S., Myers, J. K., Kramer, M., et al. (1988). One-month prevalence of mental disorders in the United States. Based on five Epidemiologic Catchment Area sites. Archives of General Psychiatry, 45, 977–986.

    PubMed  Google Scholar 

  • Roemer, L., & Orsillo, S. M. (2002). Expanding our conceptualization of and treatment for generalized anxiety disorder: Integrating mindfulness/acceptance-based approaches with existing cognitive-behavioral models. Clinical Psychology Science and Practice, 9, 54–68.

    Article  Google Scholar 

  • Rollman, B. L., Belnap, B. H., Mazumdar, S., Houck, P. R., Zhu, F., Gardner, W., et al. (2005). A randomized trial to improve the quality of treatment for Panic and Generalized Anxiety Disorders in Primary care. Archives of General Psychiatry, 62, 1332–1341.

    Article  PubMed  Google Scholar 

  • Rollman, B. L., Belnap, B. H., Mazumdar, S., Zhu, F., Kroenke, K., Schulberg, H. C., et al. (2005). Symptomatic severity of PRIME-MD diagnosed episodes of panic and generalized anxiety disorder in primary care. Journal of General Internal Medicine, 20, 623–628.

    Article  PubMed  Google Scholar 

  • Roundy, K., Cully, J. A., Stanley, M. A., Veazey, C., Souchek, J., Wray, N. P., et al. (2005). Are anxiety and depression addressed in primary care patients with COPD? Primary Care Companion Journal of Clinical Psychiatry, 715, 213–218.

    Google Scholar 

  • Roy-Byrne, P. P., Craske, M. G., Stein, M. B., Sullivan, G., Bystritsky, A., Katon, W., et al. (2005). A randomized effectiveness trial of cognitive-behavioral therapy and medication for primary care panic disorder. Archives of General, 62, 290–298.

    Article  Google Scholar 

  • Roy-Byrne, P. P., & Wagner, A. (2004). Primary care perspectives on generalized anxiety disorder. Journal of Clinical Psychiatry, 65(Suppl. 13), 20–26.

    PubMed  Google Scholar 

  • Senior, A. C., Kunik, M., Rhoades, H. M., Wilson, N., Novy, D. M., Williams, C. W., et al. (2005). Psychometric properties of self-report measures administered over the telephone. Presented at the 39th Annual Convention of the Association for Advancement of Behavior Therapy, Washington, DC, November.

    Google Scholar 

  • Sheehan, D. V., Lecrubier, Y., Sheehan, K. H., Amorim, P., Janavs, J., Weiller, E., et al. (1998). The Mini-International Neuropsychiatric Interview (MINI): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry, 59(Suppl. 20), 22–33.

    PubMed  Google Scholar 

  • Simon, G. E., Ludman, E. J., Tutty, S., Operskalski, B., & Von Korff, M. (2004). Telephone psychotherapy and telephone care management for primary care patients starting antidepressant treatment: A randomized controlled trial. Journal of the American Medical Association, 292, 935–942.

    Article  PubMed  Google Scholar 

  • Spitzer, R. L., Kroenke, K., & Williams, J. B. (1999). Validation and utility of a self-report version of PRIME-MD: The PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. Journal of the American Medical Association, 282, 1737–1744.

    Article  PubMed  Google Scholar 

  • Spitzer, R. L., Williams, J. B., Kroenke, K., Linzer, M., DeGruy, F. V., III, Hahn, S. R., et al. (1994). Utility of a new procedure for diagnosing mental disorders in primary care: The PRIME-MD 1000 study. Journal of the American Medical Association, 272, 1749–1756.

    Article  PubMed  Google Scholar 

  • Stanley, M. A., Hopko, D. R., Diefenbach, G. J., Bourland, S. L., Rodriguez, H., & Wagener, P. (2003). Cognitive-behavior therapy for late-life generalized anxiety disorder in primary care: preliminary findings. American Journal of Geriatric Psychiatry, 11, 92–96.

    PubMed  Google Scholar 

  • Stanley, M. A., Novy, D. M., Kunik, M. E., Wilson, N. L., Overall, J., & Rhoades, H. M. (2005). Preliminary outcomes: Late-life GAD in primary care. In M. S. Stanley (Chair), Expanding the boundaries for late-life anxiety: Symptoms and treatment in primary care. Symposium, Association for the Advancement of Behavior Therapy, Washington, DC, November.

    Google Scholar 

  • Stanley, M. A., Roberts, R. E., Bourland, S. L., & Novy, D. M. (2001). Anxiety disorders among older primary care patients. Journal of Clinical Geropsychology, 7, 105–116.

    Article  Google Scholar 

  • Tolin, D. F., Robison, J. T., Gaztambide, S., & Blank, K. (2005). Anxiety disorders in older Puerto Rican primary care patients. American Journal of Geriatric Psychiatry, 13, 150–156.

    PubMed  Google Scholar 

  • Unutzer, J., Katon, K., Callahan, C. M., Williams, J. W., Jr., Hunkeler, E., Harpole, L., et al. (2002). Collaborative care management of late-life depression in the primary care setting: A randomized controlled trial. Journal of the American Medical Association, 288, 2836–2845.

    Article  PubMed  Google Scholar 

  • Veazey, C., Stanley, M. A., Hopko, D., Densmore, D., & Kunik, M. (2003). Randomized controlled trial of a cognitive behavioral intervention for anxiety and depression in Chronic Obstructive Pulmonary Disease. Presented at the 37th Annual Convention of the Association for Advancement of Behavior Therapy, Boston, November.

    Google Scholar 

  • Webb, S. A., Diefenbach, G., Novy, D. M., Kunik, M., Rhoades, H. M., Weiss, B. J., et al. (2005). Utility of GAD-Q-IV and PSWQ to identify late-life GAD in a referred primary care sample. Presented at the 39th Annual Convention of the Association for Advancement of Behavior Therapy, Washington, DC, November.

    Google Scholar 

  • Weissman, M. M., Myers, J. K., Tischler, G. L., Holzer, C. E., III, Leaf, P. J., Orvaschel, H., et al. (1985). Psychiatric disorders (DSM-III) and cognitive impairment among the elderly in a U.S. urban community. Acta Psychiatrica Scandinavica, 71, 366–379.

    Article  PubMed  Google Scholar 

  • Wetherell, J. L., Birchler, G. D., Ramsdell, J., & Unutzer, J. (2007). Screening for generalized anxiety disorder in geriatric primary care patients. International Journal of Geriatric Psychiatry, 22, 115–123.

    Article  PubMed  Google Scholar 

  • Wetherell, J. L., Gatz, M., & Craske, M. G. (2003). Treatment of generalized anxiety disorder in older adults. Journal of Consulting & Clinical Psychology, 71, 31–40.

    Article  Google Scholar 

  • Wetherell, J. L., Kaplan, R. M., Kallenberg, G., Dresselhaus, T. R., Sieber, W. J., & Lang, A. J. (2004). Mental health treatment preferences of older and younger primary care patients. International Journal of Psychiatry and Medicine, 34, 219–233.

    Article  Google Scholar 

  • Wetherell, J. L., Lenze, E. J., & Stanley, M. A. (2005). Evidence-based treatment of geriatric anxiety disorders. Psychiatric Clinics of North America, 28, 871–896.

    Article  PubMed  Google Scholar 

  • Wetherell, J. L., Sorrell, J. T., Thorp, S. R., & Patterson, T. L. (2005). Psychological interventions for late-life anxiety: A review and early lessons from the CALM study. Journal of Geriatric Psychiatry and Neurology, 18, 72–82.

    Article  PubMed  Google Scholar 

  • Wittchen, H. U., Kessler, R. C., Beesdo, K., Krause, P., Hofler, M., & Hoyer, J. (2002). Generalized anxiety and depression in primary care: Prevalence, recognition, and management. Journal of Clinical Psychiatry, 63, 24–34.

    PubMed  Google Scholar 

  • Zinbarg, R. E., Barlow, D. H., Liebowitz, M., Street, L., Broadhead, E., Katon, W., et al. (1994). The DSM-IV field trial for mixed anxiety-depression. American Journal of Psychiatry, 151, 1153–1162.

    PubMed  Google Scholar 

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Brenes, G.A., Wagener, P., Stanley, M.A. (2008). Treatment of Late-Life Generalized Anxiety Disorder in Primary Care Settings. In: Gallagher-Thompson, D., Steffen, A.M., Thompson, L.W. (eds) Handbook of Behavioral and Cognitive Therapies with Older Adults. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72007-4_3

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