Abstract
The concept of “vasculogenic mimicry” (VM) was introduced to describe the unique ability of highly aggressive tumor cells to form capillary-like structure (CLS) and matrix-rich patterned network in three-dimensional cultures that mimic embryonic vasculogenic network. Here, we provide the experimental evidence that CLS structure formation requires apoptotic cell death through activation of caspase-dependent mechanism. Our results indicate that the formation of CLS is also related to the reactive oxygen species (ROS) levels.
Keywords
- Melanoma Cell
- Reactive Oxygen Species Level
- Vasculogenic Mimicry
- Skeletal Muscle Differentiation
- Intracellular Peroxide
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Brakenhielm, E., Cao, R. and Cao, Y. (2002) Suppression of angiogenesis, tumor growth and wound healing by resveratrol, a natural compound in red wine and grapes. FASEB J. 15, 1798–1800.
De Botton, S., Sabri, S., Daugas, E., Zermati, Y., Gudorti, J.E., Hermine, O. and Debili, N. (2002) Platelet formation is the consenquence of caspase activation within megakariocytes. Blood 100, 310–317.
Demierre, M.F. and Natanson, L. (2003) Chemoprevention of melanoma: an unexpected strategy. J. Clin. Oncol. 21, 158–165.
Endl, E. and Gerdes J. (2000) Ki-67 protein: fascinating forms and unknown functions. Exp. Cell. Res. 257, 231–237.
Fernando, P., Kelly, J.F., Balazsi, K., Slack, R.S. and Megeney, L.A. (2002) Caspase-3 activity is required for skeletal muscle differentiation. Proc. Natl. Acad. Sci. U.S.A. 99, 11025–11030.
Folkman, J. (2003) Fundamental concepts of the angiogenic process. Curr. Mol. Med. 3, 643–651.
Forguson, K (2005) Melanoma. J. Cont. Educ. Nurs. 36, 242–243.
Fujiki, H. (1999) Two stages of cancer prevention with green tea. J. Cancer Res. Clin. Oncol. 125, 589–597.
Garcia-Garcia, J., Micol, V., de Godes, A. and Gomez-Fernandes, J.C. (1999) The cancer chemopreventive agent resveratrol is incorporated into model membranes and inhibits protein kinase C alpha activity. Arch. Biochem. Biophys. 372, 382–388.
Hendrix, M.J., Seftor, E.A., Hess, A.R. and Seftor, R.E. (2003) Molecular plasticity of human melanoma cells. Oncogene 22, 3070–3075.
Jang, M., Cai, L., Udeani, G.O., Slowing, K.V., Thomas, C.F., Beecher, C.W. and Pezzuto, J.M. (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275, 218–220.
Lamy, S., Gingras, D. and Beliveau, R. (2002) Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation. Cancer Res. 62, 381–385.
Mandara, M., Nortilli, R., Sava, T. and Cetto, G.L. (2006) Chemotherapy for metastatic melanoma. Expert Rev. Anticancer Ther. 6, 121–130.
Maniotis, A., Folberg, R., Hess, A., Seftor, E.A., Gardner, L.M., Pe’er, J. and Hendrix, M.J. (1999) Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am. J. Pathol. 55, 739–752.
Maniotis, A.J., Chen, X., Garcia, C., deChristopher, P.J., Wu, D. and Folberg, R. (2002) Control of melanoma morphogenesis, endothelial survival and perfusion by extracellular matrix. Lab. Invest. 82, 1031–1043.
Manna, S.K., Mukhopadhyay, A. and Aggarwal, B.B. (2000) Resveratrol suppresses TNF-induced activation of NF-kappa B, activator protein-1 and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J. Immunol. 164, 6509–6519.
Meier, P., Finch, A. and Evan, G. (2000) Apoptosis in development. Nature 407, 796–801.
Meykens, F.L., Farmer, P. and Fruehanf, J.P. (2001) Redox regulation in human melanocytes and melanoma. Pigment Cell Res. 14, 148–152.
Mikhailova, I.N., Lukashina, M.I., Baryshnikov, A.Yu., Morozova, L.F., Burova, O.S., Kiselev, S. and Georgiev, G.P. (2005) Melanoma cell line as a basis for antitumor vaccine preparation. Vest. Ross. Akad. Med. Nauk [Rus] 7, 37–40.
Mogi, M. and Togari, A. (2003) Activation of caspases is required for osteoblastic differentiation. J. Biol. Chem. 278, 47477–47482.
Mukhtar, H. and Ahmad, N. (1999) Green tea in chemoprevention of cancer. Toxicol. Sci. 52, 111–117.
Schulze-Osthoff, K., Ferrari, D. and Loss, M. (1998) Apoptosis signaling by death receptors. Eur. J. Biochem. 17, 1675–1687.
Soleas, G.J., Diamandis, E.P. and Goldbery, D.M. (1997) Resveratrol: a molecule whose time has come? And gone? Clin. Biochem. 30, 91–113.
Sordet, O., Rebe, C., Plenchette, S., Hermine, O., Vanchenker, W. and Dubrez-Daloz, L. (2002) Specific involvement of caspases in the differentiation of monocytes into macrophages. Blood 100, 4446–4453.
Stone, J.R. and Collins, T. (2002) The role of hydrogen peroxide in endothelial proliferative response. Endothelium 9, 231–238.
Van der Schaft, D.W., Seftor, R.B., Seftor, E.A., Hess, A.R., Gruman, L.M., Kirschmann, D.A. and Hendrix, M.J. (2004) Effects of angiogenesis inhibitors on vascular network formation by human endothelial and melanoma cells. J. Natl. Cancer Inst. 96, 1473–1476.
Warso, M.A., Maniotis, A.J., Chen, X., Majumdar, D., Patel, M.K., Shilkaitis, A. and Folberg, R. (2001) Prognostic significance of Periodic acid-Schiff-positive patterns in primary cutaneous melanoma. Clin. Cancer Res. 7, 473–377.
Yasuda, M., Ohzeki, Y., Shimizu, S., Naito, S., Ohtsuru, A., Yamamoto, T. and Kuroiwa, Y. (1999) Stimulation of in vitro angiogenesis by hydrogen peroxide and the relation with ETS-1 in endothelial cells. Life Sci. 64, 249–258.
Zermati, Y., Garrido, C., Amsellem, S., Fashelson, S., Bouscary, D., Valenci, F. and Hermine, O. (2001) Caspase activation is required for terminal erytroid differentiation. J. Exp. Med. 193, 247–254.
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Vartanian, A., Baryshnikov, A.Y. (2007). Crosstalk Between Apoptosis and Antioxidants in Melanoma Vasculogenic Mimicry. In: Shurin, M.R., Smolkin, Y.S. (eds) Immune-Mediated Diseases. Advances in Experimental Medicine and Biology, vol 601. Springer, New York, NY. https://doi.org/10.1007/978-0-387-72005-0_15
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DOI: https://doi.org/10.1007/978-0-387-72005-0_15
Publisher Name: Springer, New York, NY
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