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TRAFs in RANK Signaling

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Book cover TNF Receptor Associated Factors (TRAFs)

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 597))

Abstract

Members of the tumor necrosis factor (TNF) family govern many diverse physiological and cellular responses including cellular proliferation, differentiation, and apoptosis. Ligands of this family interact through a distinct set of specific receptors that lack enzymatic activity and therefore are dependent on the association of adaptor molecules. One receptor/ligand pair known as receptor activator of nuclear factor-kappa B (RANK) and RANK ligand (RANKL) regulates bone remodeling, mammary gland development, and lymph node organogenesis. RANK interacts with five members of the TNF receptor-associated factor (TRAF) family, of which TRAF6 is indispensable for its signaling capability. An accumulation of evidence from various research laboratories indicates TRAFs, but more importantly TRAF6, is the key to understanding how RANKL links cytoplasmic signaling to the nuclear transcriptional program.

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Author information

Authors and Affiliations

  1. Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Box 143, 1515 Holcombe Blvd., Houston, Texas, 77030, USA

    Bryant G. Darnay

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  1. Bryant G. Darnay
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  2. Arnaud Besse
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  3. Ann T. Poblenz
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  4. Betty Lamothe
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  5. Jürg J. Jacoby
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Editors and Affiliations

  1. Department of Biochemistry, Weill Medical College of Cornell University, New York, New York, USA

    Hao Wu Ph.D.

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© 2007 Landes Bioscience and Springer Science+Business Media

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Darnay, B.G., Besse, A., Poblenz, A.T., Lamothe, B., Jacoby, J.J. (2007). TRAFs in RANK Signaling. In: Wu, H. (eds) TNF Receptor Associated Factors (TRAFs). Advances in Experimental Medicine and Biology, vol 597. Springer, New York, NY. https://doi.org/10.1007/978-0-387-70630-6_12

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