TNF Receptor Associated Factors (TRAFs)

Volume 597 of the series Advances in Experimental Medicine and Biology pp 131-151

TRAF Proteins in CD40 Signaling

  • Gail A. BishopAffiliated withDepartments of Microbiology and Internal Medicine, Interdisciplinary Graduate Program in Immunology, University of IowaIowa City VAMC
  • , Carissa R. Moore
  • , Ping Xie
  • , Laura L. Stunz
  • , Zachary J. Kraus

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The tumor necrosis factor receptor (TNFR) superfamily molecule CD40 is expressed by a wide variety of cell types following activation signals, and constitutively on B lymphocytes, macrophages, and dendritic cells. CD40 signals to cells stimulate kinase activation, gene expression, production of a antibody and a variety of cytokines, expression or upregulation of surface molecules, and protection or promotion of apoptosis. Initial steps in CD40-mediated signal cascades involve the interactions of CD40 with various members of the TNFR-associated factor (TRAF) family of cytoplasmic proteins. This review summarizes current understanding of the nature of these interactions, and how they induce and regulate CD40 functions.