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TNF Receptor Associated Factors (TRAFs) pp 1–24Cite as

Phylogeny of the TRAF/MATH Domain

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 597))

Abstract

The TNF-receptor associated factor (TRAF) domain (TD), also known as the meprin and TRAF-C homology (MATH) domain is a fold of seven anti-parallel ß-helices that participates in protein-protein interactions. This fold is broadly represented among eukaryotes, where it is found associated with a discrete set of protein-domains. Virtually all protein families encompassing a TRAF/MATH domain seem to be involved in the regulation of protein processing and ubiquitination, strongly suggesting a parallel evolution of the TRAF/MATH domain and certain proteolysis pathways in eukaryotes.

The restricted number of living organisms for which we have information of their genetic and protein make-up limits the scope and analysis of the MATH domain in evolution. However, the available information allows us to get a glimpse on the origins, distribution and evolution of the TRAF/MATH domain, which will be overviewed in this chapter.

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Authors and Affiliations

  1. Burnham Institute for Medical Research, 10901 N. Torrey Pines Road, La Jolla, California, 92037, USA

    Juan M. Zapata

  2. Centro de Biología Molecular Severo Ochoa, Universidad Autónoma de Madrid, Madrid, Spain

    Juan M. Zapata

Authors
  1. Juan M. Zapata
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  2. Vanesa Martínez-García
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  3. Sophie Lefebvre
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Editor information

Editors and Affiliations

  1. Department of Biochemistry, Weill Medical College of Cornell University, New York, New York, USA

    Hao Wu Ph.D.

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© 2007 Landes Bioscience and Springer Science+Business Media

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Zapata, J.M., Martínez-García, V., Lefebvre, S. (2007). Phylogeny of the TRAF/MATH Domain. In: Wu, H. (eds) TNF Receptor Associated Factors (TRAFs). Advances in Experimental Medicine and Biology, vol 597. Springer, New York, NY. https://doi.org/10.1007/978-0-387-70630-6_1

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