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Mitochondria pp 197–220Cite as

Mitochondrial Calcium: Role in the Normal and Ischaemic/Reperfused Myocardium

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Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 2))

Abstract

The role of intramitochondrial free [Ca2+] ([Ca2+]m) in regulating energy production in the heart is now well-accepted: An increase in [Ca2+]m, such as occurs during increased workload or adrenaline release, activates the mitochondrial dehydrogenases to increase NADH and hence ATP production (reviewed in (Hansford 1994; McCormack et al. 1990)). But [Ca2+]m could also potentially regulate whole-cell cell Ca2+ signalling, by reducing the free [Ca2+] available for contraction, or by ion channel regulation.

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  1. Elinor J. Griffiths
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  2. Christopher J. Bell
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  3. Dirki Balaska
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  4. Guy A. Rutter
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Editors and Affiliations

  1. Department of Pharmacology, University of South Alabama, Mobile, AL, 36688-0001, USA

    Stephen W. Schaffer

  2. Bristol Royal Infirmary, Bristol, BS2 8HW, UK

    M-Saadeh Suleiman

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© 2007 Springer Science+Business Media, LLC

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Griffiths, E.J., Bell, C.J., Balaska, D., Rutter, G.A. (2007). Mitochondrial Calcium: Role in the Normal and Ischaemic/Reperfused Myocardium. In: Schaffer, S.W., Suleiman, MS. (eds) Mitochondria. Advances in Biochemistry in Health and Disease, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69945-5_9

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