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Androgen Action in Prostate Cancer pp 405–424Cite as

Chromatin Remodeling and Androgen Receptor-Mediated Transcription

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Abstract

It has become apparent that the expression of human genes in chromatin is regulated by post-translational structural changes in histones, which form the major protein component of nucleosomes in chromatin. The process is generally referred to as chromatin epigenetics. Recently, it was demonstrated that histone amino-terminal tails, which extend from the core of nucleosomes out of chromatin, are methylated or acetylated at lysine residues with profound effects on gene structure and function. Since some of these changes are inherited from cells to daughter cells, lineages are established with stable histone modifications. In this way the regulation of androgen receptor-mediated transcription of target genes and the phenotype of androgen receptor-mediated prostate cancer progression are affected. The detail of this novel level of regulation is being pursued by many investigators and is summarized in this chapter.

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Acknowledgments

We thank Yankel Gabet for critically reviewing the manuscript. We acknowledge the following grant support: W81XWH-04-1-0823 and W81XWH-07-1-0067 to GAC, and W81XWH-05-1-0025 to BF from the US Department of Defense; CA109147 to GAC and DK071122 to BF from the National Institutes of Health; IRG-58-007-48 to LJ from the American Cancer Society; Awards from the Prostate Cancer Foundation to GAC; The J. Harold and Edna L. LaBriola Chair in Genetic Orthopaedic Research, held by BF.

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  1. Departments of Preventive Medicine & Urology and Norris Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Gerhard A. Coetzee

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  1. Li Jia
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  2. Omar Khalid
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  3. Baruch Frenkel
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  4. Gerhard A. Coetzee
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Correspondence to Gerhard A. Coetzee .

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James Mohler Donald Tindall

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Jia, L., Khalid, O., Frenkel, B., Coetzee, G.A. (2009). Chromatin Remodeling and Androgen Receptor-Mediated Transcription. In: Mohler, J., Tindall, D. (eds) Androgen Action in Prostate Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69179-4_18

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