Skip to main content

Ancillary Testing for the Diagnosis of Pancreatic Ductal Adenocarcinoma

  • Chapter
  • 1020 Accesses

Part of the book series: Essentials in Cytopathology ((EICP,volume 3))

Abstract

Over the last decade, the molecular biology of pancreatic ductal adenocarcinoma (PDA) has been, the subject of intense investigation. As a result, our understanding of the pathogenesis of PDA has significantly advanced. This chapter discusses some of these advances and how they and other developments have facilitated ancillary testing of cytologic samples for the diagnosis of PDA.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   109.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Suggested Reading

  • Chhieng DC, Benson E, Eltoum I, et al. MUC1 and MUC2 expression in pancreatic ductal carcinoma obtained by fine-needle aspiration. Cancer 2003;99:365–371.

    Article  PubMed  CAS  Google Scholar 

  • Giorgadze TA, Peterman H, Baloch ZW, et al. Diagnostic utility of mucin profile in fine-needle aspiration specimens of the pancreas: an immunohistochemical study with surgical pathology correlation. Cancer 2006;108:186–197.

    Article  PubMed  Google Scholar 

  • Jhala N, Jhala D, Vickers SM, et al. Biomarkers in diagnosis of pancreatic carcinoma in fine-needle aspirates. Am J Clin Pathol 2006;126:572–579.

    Article  PubMed  CAS  Google Scholar 

  • Lapkus O, Gologan O, Liu Y, et al. Determination of sequential mutation accumulation in pancreas and bile duct brushing cytology. Mod Pathol 2006;19:907–913.

    Article  PubMed  Google Scholar 

  • Maitra A, Adsay NV, Argani P, et al. Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray. Mod Pathol 2003;16:902–912.

    Article  PubMed  Google Scholar 

  • McCarthy DM, Maitra A, Argani P, et al. Novel markers of pancreatic adenocarcinoma in fine-needle aspiration: mesothelin and prostate stem cell antigen labeling increases accuracy in cytologically borderline cases. Appl Immunohistochem Mol Morphol 2003;11:238–243.

    PubMed  CAS  Google Scholar 

  • Saxby AJ, Nielsen A, Scarlett CJ, et al. Assessment of HER-2 status in pancreatic adenocarcinoma: correlation of immunohistochemistry, quantitative real-time RT-PCR, and FISH with aneuploidy and survival. Am J Surg Pathol 2005;29:1125–1133.

    Article  PubMed  Google Scholar 

  • Tada M, Komatsu Y, Kawabe T, et al. Quantitative analysis of K-ras gene mutation in pancreatic tissue obtained by endoscopic ultrasonography-guided fine needle aspiration: clinical utility for diagnosis of pancreatic tumor. Am J Gastroenterol 2002;97:2263–2270.

    Article  PubMed  CAS  Google Scholar 

  • Wilentz RE, Goggins M, Redston M, et al. Genetic, immunohistochemical, and clinical features of medullary carcinoma of the pancreas: a newly described and characterized entity. Am J Pathol 2000;156:1641–1651.

    Article  PubMed  CAS  Google Scholar 

  • van Heek T, Rader AE, Offerhaus GJ, et al. K-ras, p53, and DPC4 (MAD4) alterations in fine-needle aspirates of the pancreas: a molecular panel correlates with and supplements cytologic diagnosis. Am J Clin Pathol 2002;117:755–765.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Chhieng, D.C., Stelow, E.B. (2007). Ancillary Testing for the Diagnosis of Pancreatic Ductal Adenocarcinoma. In: Pancreatic Cytopathology. Essentials in Cytopathology, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-68947-0_4

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-68947-0_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-68946-3

  • Online ISBN: 978-0-387-68947-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics