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Gynecologic and Reproductive Concerns

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The seven U.S. Mercury astronauts, all of whom were male, were selected by NASA in 1959 to make the first human space flights. Nevertheless, the era of human space flight started not in the United States but in the Soviet Union with the single-orbit flight of a male cosmonaut, Yuri Gagarin, on Vostok 1 in April 1961. The Soviets also inaugurated female participation in space flight. The first woman to fly in space was Valentina Tereshkova, who spent 3 days on Vostok 6 in 1963. Nineteen years later another Soviet woman, Svetlana Savitskaya, ventured into space on the flight of Soyuz-T7 in August 1982. In June 1983, the first female U.S. astronaut, Sally Ride, joined this elite group of female spacefarers.

The process by which the first astronauts were chosen for the U.S. space program was initiated in the late 1950s. The U.S. Government determined that the first groups from which astronauts were to be selected would be limited to military test pilots. Although several women were able to complete the medical selection examinations (the same ones given to the men), none of them qualified for the simple reason that all military test pilots at that time were men. This policy thus effectively delayed space flights by U.S. women for 2 decades [1]. The first U.S. astronaut class to include women was formed in 1978; of that class of 35, 6 were women. To date, more than 45 female career astronauts (pilots or mission specialists) have been selected for the U.S. space program. One female Canadian astronaut and three female payload specialists have flown on the shuttle.

Regardless of the relative assets and liabilities of using men or women in future space crews, these crews will include people of both sexes. It is therefore prudent that the reproductive and gynecologic issues associated with selecting, training, and assigning female crewmembers to space missions be examined. This chapter addresses gynecologic medical standards and female astronaut selection, reproductive and operational gynecologic considerations during training and space flight, pregnancy after space flight, and gynecologic considerations for long-duration space flights.

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References

  1. Nicogossian AE, Pool SL, Uri JJ. Historical perspectives. In: Nico-gossian AE, Huntoon CL, Pool SL (eds.), Space Physiology and Medicine, 3rd edn. Philadelphia: Lea and Febiger; 1993:5-16.

    Google Scholar 

  2. Lyons TJ. Women in the fast jet cockpit: aeromedical consider-ations. Aviat Space Environ Med 1992; 63:809-818.

    PubMed  CAS  Google Scholar 

  3. Lyons TJ. Women in the military cockpit. Brooks Air Force Base, TX. Armstrong Laboratory Technical Report AL-TR-1991-0068.

    Google Scholar 

  4. Santy PA. Women in space: a medical perspective. J Am Med Womens Assoc 1984; 39:13-17.

    PubMed  CAS  Google Scholar 

  5. Rock JA, Fortney SM. Medical and surgical considerations for women in spaceflight. Obstet Gynecol Surv 1984; 39:525-535.

    PubMed  CAS  Google Scholar 

  6. National Council on Radiation Protection and Measurements. Guidance on Radiation Received in Space Flight. NCRP Report No. 98, 1989.

    Google Scholar 

  7. Merrill JA. Endometrial induction of endometriosis across Millipore filters. Am J Obstet Gynecol 1966; 94:780-790.

    PubMed  CAS  Google Scholar 

  8. Sampson JA. Peritoneal endometriosis due to menstrual dis-semination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol 1927; 14:422.

    Google Scholar 

  9. Scott RB, Te Linde RW, Wharton LR. Further studies on experi-mental endometriosis. Am J Obstet Gynecol 1953; 66:1082.

    PubMed  CAS  Google Scholar 

  10. Te Linde RW, Scott RB. Experimental endometriosis. Am J Obstet Gynecol 1950; 60:1147-1166.

    PubMed  CAS  Google Scholar 

  11. Fanton JW, Golden JG. Radiation-induced endometriosis in Macaca mulatta. Radiat Res 1991; 126:141-146.

    Article  PubMed  CAS  Google Scholar 

  12. McClure HM, Ridley JH, Graham CE. Disseminated endometri-osis in a Rhesus monkey. Histogenesis and possible relationship to irradiation exposure. J Med Assoc Ga 1971; 60:11-13.

    PubMed  CAS  Google Scholar 

  13. Splitter GA, Kirk JH, Mac Kenzie WF, Rawlings CA. Endome-triosis in four irradiated monkeys. Vet Pathol 1972; 9:249-262.

    Article  PubMed  CAS  Google Scholar 

  14. Wood DH. Long-term mortality and cancer risk in irradiated rhe-sus monkeys. Radiat Res 1991; 126:132-140.

    Article  PubMed  CAS  Google Scholar 

  15. Wood DH, Yochmowth MG, Salmon YL, Eason RL, Boster RA. Proton irradiation and endometriosis. Aviat Space Environ Med 1983; 54:718-724.

    PubMed  CAS  Google Scholar 

  16. Braun DP, Dmowski WP. Endometriosis: abnormal endometrium and dysfunctional immune response. Curr Opin Obstet Gynecol 1998; 10:365-369.

    Article  PubMed  CAS  Google Scholar 

  17. Dmowski WP. Immunological aspects of endometriosis. Int J Gynaecol Obstet 1995; 50:S3-S10.

    Article  PubMed  Google Scholar 

  18. Taylor GR, Konstantinova I, Sonnenfeld G, Jennings RT. Changes in the immune system during and after space flight. In: Bonting SL (ed.), Advances in Space Biology and Medicine, Vol. 6. JAI Press Inc. 1997:1-32.

    Google Scholar 

  19. Taylor MB. Women in diving. In: Bove AA (ed.), Diving Medi-cine. 3rd ed. Philadelphia, PA: WB Saunders; 1997:89-107.

    Google Scholar 

  20. Andrews WC. What’s new in preventing and treating osteopo-rosis. Postgrad Med 1998; 104:89-97.

    Article  PubMed  CAS  Google Scholar 

  21. Kohrt WM, Snead DB, Slatopolsky E, Birge SJ. Additive effect of weight-bearing exercise and estrogen on bone mineral density in older women. J Bone Miner Res 1995; 9:1303-1311.

    Article  Google Scholar 

  22. Naessen T, Persson I, Adami HO, et al. Hormone replacement therapy and the risk for first hip fracture. Ann Intern Med 1990; 113:95-103.

    PubMed  CAS  Google Scholar 

  23. Notelovitz M. Estrogen therapy and osteoporosis: principles and practice. Am J Med Sci 1997; 313:2-12.

    Article  PubMed  CAS  Google Scholar 

  24. Prince RL, Smith M, Dick IM, et al. Prevention of postmeno-pausal osteoporosis. N Engl J Med 1991; 325:1189-1195.

    PubMed  CAS  Google Scholar 

  25. Cann CE, Martin MC, Genant HK, et al. Decreased spinal min-eral content in amenorrheic women. JAMA 1984; 251:626-629.

    Article  PubMed  CAS  Google Scholar 

  26. Drinkwater BL, Nilson K, Chesnut CH, et al. Bone mineral content of amenorrheic and eumenorrheic athletes. N Engl J Med 1984; 311:277-281.

    Article  PubMed  CAS  Google Scholar 

  27. Jones KP, Ravnikar VA, Tulchinsky D, et al. Comparison of bone density in amenorrheic women due to athletics, weight loss and premature menopause. Obstet Gynecol 1985; 66:5-8.

    PubMed  CAS  Google Scholar 

  28. Lane N, Bloch DA, Jones HH, et al. Long distance running, bone density, and osteoarthritis. JAMA 1986; 255:1147-1151.

    Article  PubMed  CAS  Google Scholar 

  29. Lindberg JS. Exercise induced amenorrhea and bone density. Ann Intern Med 1984; 101:647-648.

    PubMed  CAS  Google Scholar 

  30. Lloyd T, Myers C, Buchanan JR, et al. Collegiate women athletes with irregular menses during adolescence have decreased bone mineral density. Obstet Gynecol 1988; 72:639-642.

    PubMed  CAS  Google Scholar 

  31. Lloyd T, Triantafyllou SJ, Baker ER, et al. Women athletes with menstrual irregularity have increased musculoskeletal injuries. Med Sci Sports Exerc 1986; 18:374-379.

    PubMed  CAS  Google Scholar 

  32. Marcus R, Cann C, Madvig P, et al. Menstrual function and bone mass in elite women distance runners. Ann Intern Med 1985; 102:158-163.

    PubMed  CAS  Google Scholar 

  33. Myburgh KH, Hutchins J, Fataar AB, et al. Low bone density is an etiologic factor in stress fractures in athletes. Ann Intern Med 1990; 113:754-759.

    PubMed  CAS  Google Scholar 

  34. Prior JC, Cameron K, Yuen BH, et al. Menstrual cycle changes with marathon training: anovulation and short luteal phase. Can J Appl Sports Sci 1982; 7:173-177.

    CAS  Google Scholar 

  35. Russell JB, Mitchell D, Musey PI, et al. The relationship of exercise to anovulatory cycles in female athletes: hormonal and physical characteristics. Obstet Gynecol 1984; 63:452-456.

    PubMed  CAS  Google Scholar 

  36. Shangold MM, Levine HS. The effect of marathon training upon menstrual function. Am J Obstet Gynecol 1982; 143: 862-869.

    PubMed  CAS  Google Scholar 

  37. Shangold M, Rebar RW, Wentz AC, et al. Evaluation and management of menstrual dysfunction in athletes. JAMA 1990; 263:1665-1669.

    Article  PubMed  CAS  Google Scholar 

  38. Corson SL. Oral contraceptives for the prevention of osteoporo-sis. J Reprod Med 1993; 38:1015-1020.

    PubMed  CAS  Google Scholar 

  39. Cummings DC. Exercise-associated amenorrhea, low bone density, and estrogen replacement therapy. Arch Intern Med 1996; 156:2193-2195.

    Article  Google Scholar 

  40. DeCherney A. Bone-sparing properties of oral contraceptives. Am J Obstet Gynecol 1996; 174:15-20.

    Article  PubMed  CAS  Google Scholar 

  41. Lohman T, Going S, Pamenter R, et al. Effects of resistance training on regional and total bone mineral density in premeno-pausal women: a randomized prospective study. J Bone Miner Res 1995; 10:1015-1024.

    Article  PubMed  CAS  Google Scholar 

  42. Hosking D, Chilvers CED, Christiansen C, et al. Prevention of bone loss with alendronate in postmenopausal women under age 60 years of age. N Engl J Med 1998; 338:485-492.

    Article  PubMed  CAS  Google Scholar 

  43. Delmas PD, Bjarnason NH, Mitlak BH, et al. Effects of raloxi-fene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. N Engl J Med 1997; 337:1641-1647.

    Article  PubMed  CAS  Google Scholar 

  44. Davis JR. Medical issues for a Mars mission. Texas Med 1998; 94:47-55.

    CAS  Google Scholar 

  45. Jennings RT, Santy PA. Reproduction in the space environment: Part II. Concerns for human reproduction. Obstet Gynecol Surv 1989; 45:7-17.

    Article  Google Scholar 

  46. Santy PA, Jennings RT. Human reproductive issues in space. Adv Space Res 1992; 2:151-155.

    Article  Google Scholar 

  47. Warren MP. Effects of space travel on reproduction. Obstet Gynecol Surv 1989; 44:85-88.

    Article  PubMed  CAS  Google Scholar 

  48. National Council on Radiation Protection and Measurement. Limitation of Exposure to Ionizing Radiation. Bethesda, MD: National Research Council; 1993. NCRP Report No. 116.

    Google Scholar 

  49. Mole RH. Consequences of pre-natal radiation exposure for post-natal development. A review. Int J Radiat Biol Relat Stud Phys Chem Med 1982; 42:1-12.

    Article  PubMed  CAS  Google Scholar 

  50. Mole RH. Radiation risks to the individual in utero. Report of a scientific symposium: Radiation risks to the developing ner-vous system. Int J Radiat Biol Relat Stud Phys Chem Med 1986; 49:183-189.

    PubMed  CAS  Google Scholar 

  51. Otake M, Schull WJ. In utero exposure to A-bomb radiation and mental retardation; a reassessment. Br J Radiol 1984; 57:409-414.

    Article  PubMed  CAS  Google Scholar 

  52. Otake M, Schull WJ, Lee S. Threshold for radiation-related severe mental retardation in prenatally exposed A-bomb survi-vors: a reanalysis. Int J Radiat Biol 1996; 70:755-763.

    Article  PubMed  CAS  Google Scholar 

  53. Reyners H, Gianfelic de Reyners E, Poortmans F, et al. Brain atrophy after foetal exposure to very low doses of ionizing radia-tion. Int J Radiat Biol 1992; 62:619-626.

    Article  PubMed  CAS  Google Scholar 

  54. Devi PU, Baskar R. Influence of gestational age at exposure on the prenatal effects of gamma radiation. Int J Radiat Biol 1996; 70:45-52.

    Article  PubMed  CAS  Google Scholar 

  55. Santy PA, Jennings RT, Craigie D. Reproduction in the space environment: Part 1. Animal reproductive studies. Obstet Gyne-col Surv 1989; 45:1-17.

    Article  Google Scholar 

  56. Snetkova E, Chelnaya N, Serova L, et al. Effects of space flight on Zenopus laevis larval development. J Exp Zool 1995; 273:21-32.

    Article  PubMed  CAS  Google Scholar 

  57. Suda T. Lessons from the space experiment SL-J/FMPT/L7: the effect of microgravity on chicken embryogenesis and bone for-mation. Bone 1998; 22:73S-78S.

    Article  PubMed  CAS  Google Scholar 

  58. Suda R, Abe E, Shinki T, et al. The role of gravity in chick embryogenesis. FEBS Lett 1994; 340:34-38.

    Article  PubMed  CAS  Google Scholar 

  59. Wong AM, DeSantis M. Rat gestation during spaceflight: out-comes for dams and their offspring born after return to earth. Integr Physiol Behav Sci 1997; 32:322-342.

    Article  PubMed  CAS  Google Scholar 

  60. Kirkpatrick AW, Campbell MR, Brenneman FD, et al. Trauma laparotomy in space: a discussion of the potential indications, conduct of operation, and technical support for the treatment of abdominal trauma during long-duration space exploration. Pre-sented at the 28th International Conference of Environmental Systems, Danvers, MA, 13-16 July 1998. SAE Technical Paper Series 981601.

    Google Scholar 

  61. Kirpatrick AW, Campbell MR, Novinkov OL, et al. Blunt trauma and operative care in microgravity: a review of microgravity physiological and surgical investigations with implications for critical care and operative treatment in space. J Am Coll Surg 1997; 184:441-445.

    Google Scholar 

  62. Smith RS, Fry WR, Morabito DJ, et al. Therapeutic laparoscopy in trauma. Am J Surg 1995; 170:632-637.

    Article  PubMed  CAS  Google Scholar 

  63. Townsend MC, Flanebaum L, Choban PS, et al. Diagnostic lapa-roscopy as and adjunct to selective conservative management of solid organ injuries after blunt abdominal trauma. J Trauma 1993; 35:647-651.

    Article  PubMed  CAS  Google Scholar 

  64. Campbell MR, Johnston SL. Surgical bleeding in microgravity. Surg Gynecol Obstet 1993; 177:121-125.

    PubMed  CAS  Google Scholar 

  65. Campbell MR, Billica RD, Johnston SL. Animal surgery in microgravity. Aviat Space Environ Med 1993; 64:58-62.

    PubMed  CAS  Google Scholar 

  66. Campbell MR, Billica RD, Jennings RT, et al. Laparoscopic sur-gery in weightlessness. Surg Endosc 1996; 10:111-117.

    PubMed  CAS  Google Scholar 

  67. Campbell MR, Billica RD. A review of microgravity surgical investigations. Aviat Space Environ Med 1992; 63:524-528.

    PubMed  CAS  Google Scholar 

  68. Markham SM, Rock JA. Deploying and testing an expandable surgical chamber in microgravity. Aviat Space Environ Med 1989; 60:76-79.

    PubMed  CAS  Google Scholar 

  69. McCuaig K. Aseptic technique in microgravity. Surg Gynecol Obstet 1992; 175:466-476.

    PubMed  CAS  Google Scholar 

  70. Rock JA, Hesla JS, Repke JT, et al. A surgical isolation system for gynecological and obstetrical surgery. Am J Gynecol Health 1989; 3:126-129.

    Google Scholar 

  71. Mutke HG. Equipment for surgical interventions and childbirth in weightlessness. Acta Astronautica 1981; 1:399-401.

    Article  Google Scholar 

  72. Colvard M, Kuo P, Caleel R, et al. Laser surgical procedures in the operational KC-135E aviation environment. Aviat Space Environ Med 1992; 63:619-623.

    PubMed  CAS  Google Scholar 

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Jennings, R.T., Baker, E.S. (2008). Gynecologic and Reproductive Concerns. In: Barratt, M.R., Pool, S.L. (eds) Principles of Clinical Medicine for Space Flight. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68164-1_18

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  • DOI: https://doi.org/10.1007/978-0-387-68164-1_18

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