Abstract
A computerized PubMed search of MEDLINE 1966-October 2005 was performed. The terms “tinnitus” and “antidepressant-agents” were exploded and the resulting articles were cross-referenced, yielding 26 articles. An additional search of the following subject headings was performed: “tinnitus” was cross-referenced with the textwords and medical subject headings “antidepressive agents,” “antidepressive,” “antidepressant,” “amitriptyline,” “clomipramine,” “cyclobenzaprine,” “desipramine,” “desmethyldoxepin,” “dothiepin,” “doxepin,” “imipramine,” “iprindole,” “lofepramine,” “metapramine,” “mirtazapine,” “nortriptyline,” “opipramol,” “protriptyline,” “tianeptine,” “trimipramine.” These resulting articles were then reviewed to identify those that met the following inclusion criteria: 1) patients with subjective tinnitus of ≥6-month duration between the ages of 18 and 70, 2) treatment with antidepressant agents versus placebo, 3) outcomes measured in terms of validated scales, and 4) randomized controlled trials.
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References
Bayar N, Boke B, Turan E, Belgin E. Efficacy of amitriptyline in the treatment of subjective tinnitus. J Otolaryngol 2001;30(5):300–303.
Sullivan M, Katon W, Russo J, Dobie R, Sakai C. A randomized trial of nortriptyline for severe chronic tinnitus. Arch Intern Med 1993;153(19):2251–2259.
Mihail M, Crowley JM, Walden BE, Fishburne J, Reinwall JF, Zajtchuk JT. The tricyclic trimipramine in the treatment of subjective tinnitus. Ann Otol Rhinol Laryngol 1988;97(2 Pt 1):120–123.
Dobie RA, Sakai CS, Sullivan MD, Katon WJ, Russo J. Antidepressant treatment of tinnitus patients: report of a randomized clinical trial and clinical prediction of benefit. Am J Otol 1993;14(1):18–23.
References
Simpson JA, Gilbert AM, Weiner GM, Davies WE. The assessment of lamotrigine, an antiepileptic drug, in the treatment of tinnitus. J Laryngol Otol 1999;20:627–631.
Melding PS, Goodey RJ. The treatment of tinnitus with oral anticonvulsants. J Laryngol Otol 1979;93:111–122.
Gananca MM, Caovilla HH, Gananca FF, et al. Clonazepam in the pharmacological treatment of vertigo and tinnitus. Int Tinnitus J 2002;8(1):50–53.
References
Berry JA, Gold SL, Frederick EA, Gray WC, Staecker H. Patient-based outcomes in patients with primary tinnitus undergoing tinnitus retraining therapy. Arch Otolaryngol Head Neck Surg 2002;128(10):1153–1157.
Dineen R, Doyle J, Bench J, Perry A. The influence of training on tinnitus perception: an evaluation 12 months after tinnitus management training. Br J Audiol 1999;33(1):29–51.
Folmer RL. Long-term reductions in tinnitus severity. BMC Ear Nose Throat Disord 2002;2(1):3.
Jastreboff PJ, Gray WC, Gold SL. Neurophysiological approach to tinnitus patients. Am J Otol 1996;17(2):236–240.
References
Martin FW, Colman BH. Tinnitus: a double-blind crossover controlled trial to evaluate the use of lignocaine. Clin Otolaryngol Allied Sci, 1980;5(1):3–11.
Majumdar B, Mason SM, Gibbin KP. An electrocochleographic study of the effects of lignocaine on patients with tinnitus. Clin Otolaryngol Allied Sci 1983;8(3):175–180.
Israel JM, Connelly JS, McTigue ST, Brumme RE, Brown J. Lidocaine in the treatment of tinnitus aurium. A double-blind study. Arch Otolaryngol 1982;108(8):471–473.
Hulshof JH, Vermeij P. The effect of intravenous lidocaine and several different doses of oral tocainide HC1 on tinnitus. A dose-finding study. Acta Otolaryngol 1984;98(3–4):231–238.
Duckert LG, Rees TS. Treatment of tinnitus with intravenous lidocaine: a double-blind randomized trial. Otolaryngol Head Neck Surg 1983;91(5):550–555.
Baguley DM, Jones S, Wilkins I, Axon PR, Moffat DA. The inhibitory effect of intravenous lidocaine infusion on tinnitus after translabyrinthine removal of vestibular schwannoma: a double-blind, placebo-controlled, cross-over study. Otol Neurotol 2005;26(2):169–176.
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Finnell, J., Piccirillo, J.F., Bauer, C., Brozoski, T.J., Perring, A. (2008). Tinnitus. In: Shin, J.J., et al. Evidence-Based Otolaryngology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49979-6_16
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DOI: https://doi.org/10.1007/978-0-387-49979-6_16
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