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Cardiac Mechanotransduction pp 134–144Cite as

Mechanotransduction of the Endocrine Heart

Paracrine and Intracellular Regulation of B-Type Natriuretic Peptide Synthesis

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Abstract

Cardiac overload initiates a process, which aims to maintain and adapt cardiovascular system to altered hemodynamics. In adults, myocardial mass increases mainly due to enlargement of individual myocytes (for reviews, see refs. 1,2). Cardiac pressure overload in conditions such as aortic stenosis or hypertension, results in parallel addition of sarcomeres and increases width of myocytes, which in turn, augment left ventricular wall thickness.2 However, when mechanical and neurohumoral stress are sustained, the adaptive mechanisms eventually fail and further myocardial remodelling leads to ventricular dilation and impairment of cardiac contractile function. Cardiac output reduces until being inadequate to maintain efficient blood circulation of the whole organism and the syndrome of congestive heart failure occurs.2,3 At the cellular level, the cardiac growth and failure is due to a complex pattern of signaling mechanisms and molecules. In 1980s, identification of genes associated with cardiac hypertrophy were accompanied by the discovery of natriuretic peptides in the heart.4,5 Since then, this has been followed by characterization of regulatory mechanisms in natriuretic peptide secretion and synthesis and further insight of the signaling mechanisms and of the development of cardiac hypertrophy has been achieved.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, University of Oulu, P.O. Box 5000, 90014, Oulun yliopisto, Oulu, Finland

    Sampsa Pikkarainen, Heikki Tokola & Heikki Ruskoaho

  2. Biocenter Oulu, University of Oulu, P.O. Box 5000, 90014, Oulun yliopisto, Oulu, Finland

    Sampsa Pikkarainen, Heikki Tokola & Heikki Ruskoaho

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  1. Sampsa Pikkarainen
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Pikkarainen, S., Tokola, H., Ruskoaho, H. (2007). Mechanotransduction of the Endocrine Heart. In: Cardiac Mechanotransduction. Springer, New York, NY. https://doi.org/10.1007/978-0-387-48868-4_9

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