CLINICAL STUDIES WITH CURCUMIN
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Curcumin has long been expected to be a therapeutic or preventive agent for several major human diseases because of its antioxidative, anti-inflammatory, and anticancerous effects. In phase I clinical studies, curcumin with doses up to 3600–8000 mg daily for 4 months did not result in discernible toxicities except mild nausea and diarrhea. The pharmacokinetic studies of curcumin indicated in general a low bioavailability of curcumin following oral application. Nevertheless, the pharmacologically active concentration of curcumin could be achieved in colorectal tissue in patients taking curcumin orally and might also be achievable in tissues such as skin and oral mucosa, which are directly exposed to the drugs applied locally or topically.
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- CLINICAL STUDIES WITH CURCUMIN
- Book Title
- The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease
- pp 471-480
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- ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
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- Springer US
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- 6. Ransom Horne, Jr., Professor of Cancer Research Professor of Cancer Medicine (Biochemistry)and Chief, Cytokine Research Section Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center
- 7. Chief and Professor National Research Laboratory of Molecular Carcinogenesis and Chemoprevention College of Pharmacy, Seoul National University
- 8. Assistant Professor Department of Biology, Texas Southern University
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