Skip to main content
SpringerLink
Log in

PROTECTION FROM ACUTE AND CHRONIC LUNG DISEASES BY CURCUMIN

  • Chapter
Book cover The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

Part of the book series: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY ((AEMB,volume 595))

Abstract

The aim of this review has been to describe the current state of the therapeutic potential of curcumin in acute and chronic lung injuries. Occupational and environmental exposures to mineral dusts, airborne pollutants, cigarette smoke, chemotherapy, and radiotherapy injure the lungs, resulting in acute and chronic inflammatory lung diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1. B. B. Aggarwal and S. Shishodia, Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals, Reasoning for seasoning. Ann NY Acad Sci 1030, 434 (2004).

    Article  PubMed  CAS  Google Scholar 

  2. 2. S. Shishodia, S. Gautam, and B. B. Aggarwal, Curcumin: Getting back to the roots. Ann NY Acad Sci 1056, 206 (2005).

    Article  PubMed  CAS  Google Scholar 

  3. 3. K. C. Thresiamma, J. George, and R. Kuttan, Protective effect of curcumin, ellagic acid and bixin on radiation induced toxicity. Indian J Exp Biol 34, 845 (1996).

    PubMed  CAS  Google Scholar 

  4. 4. N. Venkatesan, Pulmonary protective effects of curcumin against paraquat toxicity Life Sci 66, PL21 (2000).

    Article  PubMed  CAS  Google Scholar 

  5. 5. N. Venkatesan and G. Chandrakasan, Modulation of cyclophosphamide-induced early lung injury by curcumin, an anti-inflammatory antioxidant. Mol Cell Biochem 142, 79 (1995).

    Article  PubMed  CAS  Google Scholar 

  6. 6. N. Venkatesan, V. Punithavathi, and G. Chandrakasan, Curcumin protects bleomycin-induced lung injury in rats, Life Sci 61, PL51 (1997).

    Article  PubMed  CAS  Google Scholar 

  7. 7. D. Punithavathi, N. Venkatesan, and M. Babu, Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats. Br J Pharmacol 131, 169 (2000).

    Article  PubMed  CAS  Google Scholar 

  8. 8. D. Punithavathi, N. Venkatesan, and M. Babu, Protective effects of curcumin against amiodarone-induced pulmonary fibrosis in rats. Br J Pharmacol 139, 1342 (2003).

    Article  PubMed  CAS  Google Scholar 

  9. 9. C. Kalpana and V. P. Menon, Modulatory effects of curcumin on lipid peroxidation and antioxidant status during nicotine-induced toxicity. Pol J Pharmacol 56, 581 (2004).

    PubMed  CAS  Google Scholar 

  10. 10. B. Madan and B. Ghosh, Diferuloylmethane inhibits neutrophil infiltration and improves survival of mice in high-dose endotoxin shock. Shock 19, 91 (2003).

    Article  PubMed  CAS  Google Scholar 

  11. 11. A. Ram, M. Das, and B. Ghosh, Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs. Biol Pharm Bull 26, 1021 (2003).

    Article  PubMed  CAS  Google Scholar 

  12. 12. T. J. Gross and G. W. Hunninghake, Idiopathic pulmonary fibrosis. N Engl J Med 345, 517 (2001).

    Article  PubMed  CAS  Google Scholar 

  13. 13. P. Camus, A. Fanton, P. Bonniaud, C. Camus, and P. Foucher, Interstitial lung disease induced by drugs and radiation. Respiration. 71, 301 (2004).

    Article  PubMed  Google Scholar 

  14. 14. J. A. Copper, Jr. Drug-induced lung disease. Adv Intern Med 42, 231 (1977).

    Google Scholar 

  15. 15. E. Crouch, Pathobiology of pulmonary fibrosis. Am J Physiol 259, L159 (1990).

    PubMed  CAS  Google Scholar 

  16. 16. M. P. Keane, R. M. Strieter, and J. A. Belperio, Mechanisms and mediators of pulmonary fibrosis. Crit Rev Immunol 25, 429 (2005).

    PubMed  CAS  Google Scholar 

  17. 17. M. Gharaee-Kermani and S. H. Phan, Molecular mechanisms of and possible treatment strategies for idiopathic pulmonary fibrosis. Curr Pharm Des 11, 3943 (2005).

    Article  PubMed  CAS  Google Scholar 

  18. 18. D. Bouros and K. M. Antoniou, Current and future therapeutic approaches in idiopathic pulmonary fibrosis. Eur Respir J 26, 693 (2005).

    Article  PubMed  CAS  Google Scholar 

  19. 19. R. C. Chambers and G. J. Laurent, Coagulation cascade proteases and tissue fibrosis. Biochem Soc Trans 30, 194 (2002).

    Article  PubMed  CAS  Google Scholar 

  20. 20. N. Hashimoto, H. Jin, T. Liu, S. W. Chensue, and S. H. Phan, Bone marrow-derived progenitor cells in pulmonary fibrosis J Clin Invest 113(2), 243–252 (2004).

    Article  PubMed  CAS  Google Scholar 

  21. 21. K K. Soudamini, M. C. Unnikrishnan, K. B. Soni, and R. Kuttan, Inhibition of lipid peroxidation and cholesterol levels in mice by curcumin. Indian J Physiol Pharmacol 36, 239 (1992).

    PubMed  CAS  Google Scholar 

  22. 22. W. H. Chung, B. M. Bennett, W. J. Racz, J. F. Brien, and T. E. Massey, Induction of c-jun and TGF-β1in Fischer 344 rats during amiodarone-induced pulmonary fibrosis, Am J Physiol 281, L1180 (2001).

    CAS  Google Scholar 

  23. 23. C. P. Denton and C. M. Black, Targeted therapy comes of age in scleroderma. Trends Immunol 26, 596 (2005).

    Article  PubMed  CAS  Google Scholar 

  24. 24. E. Tourkina, P. Gooz, J. C. Oates, A. Ludwicka-Bradley, R. M. Silver, and S. Hoffman, Curcumin-induced apoptosis in scleroderma lung fibroblasts, role of protein kinase cepsilon. Am J Respir Cell Mol Biol 31, 28 (2004).

    Article  PubMed  CAS  Google Scholar 

  25. 25. R. M. Senior and S. D. Shapiro, Chronic obstructive pulmonary disease: Epidemiology, pathophysiology, and pathogenesis. In: Fishman's Pulmonary Diseases and Disorders. Volume 1, A. P. Fishman et al., eds. New York: McGraw-Hill, 1998, pp. 659–681.

    Google Scholar 

  26. 26. P. M. O'Byrne and D. S. Postma, The many faces of airway inflammation: Asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 15, S41 (1999).

    Google Scholar 

  27. 27. J. R. Spurzem and S. I. Rennard, Pathogenesis of COPD. Semin Respir Crit Care Med 26, 142 (2005).

    Article  PubMed  Google Scholar 

  28. 28. M. Saetta, Activated T-lymphocytes and macrophages in bronchial mucosa of subjects with chronic bronchitis. Am Rev Respir Dis 147, 301 (1993).

    PubMed  CAS  Google Scholar 

  29. 29. M. Saetta, CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160, 711 (1999).

    PubMed  CAS  Google Scholar 

  30. 30. J. L. Wright and A. Churg, Animal models of cigarette smoke-induced COPD. Chest 122, 301S (2002).

    Article  PubMed  Google Scholar 

  31. 31. V. L. Kinnula, Focus on antioxidant enzymes and antioxidant strategies in smoking related airway diseases. Thorax 60, 693 (2004).

    Article  Google Scholar 

  32. 32. W. Boots, G. R. Haenen, and A. Bast, Oxidant metabolism in chronic obstructive pulmonary disease Eur Respir J 46(Suppl),14 (2003).

    Article  Google Scholar 

  33. 33. P. J. Barnes, COPD: Is there light at the end of the tunnel? Curr Opin Pharmacol 4, 263 (2004).

    Article  PubMed  CAS  Google Scholar 

  34. 34. C. Kalpana and V. P. Menon, Curcumin ameliorates oxidative stress during nicotine-induced lung toxicity in Wistar rats. Ital J Biochem 53, 82 (2004).

    PubMed  CAS  Google Scholar 

  35. 35. S. Shishodia, P. Potdar, C. G. Gairola, and B. B. Aggarwal, Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBα kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. Carcinogenesis 24, 1269 (2003).

    Article  PubMed  CAS  Google Scholar 

  36. 36. M. A. Matthay and G. A. Zimmerman, Acute lung injury and the acute respiratory distress syndrome: Four decades of inquiry into pathogenesis and rational management. Am J Respir Cell Mol Biol 33, 319 (2005).

    Article  PubMed  CAS  Google Scholar 

  37. 37. M. A. Schwarz, Acute lung injury: cellular mechanisms and derangements. Paediatr Respir Rev 2, 3 (2001).

    Article  PubMed  CAS  Google Scholar 

  38. 38. G. J. Bellingan, The pulmonary physician in critical care: The pathogenesis of ALI/ARDS. Thorax 57, 540 (2002).

    Article  PubMed  CAS  Google Scholar 

  39. 39. R. Jain and A. DalNogare, Pharmacological therapy for acute respiratory distress syndrome. Mayo Clin Proc 81, 205 (2006).

    PubMed  CAS  Google Scholar 

  40. 40. N. R. MacIntyre, Current issues in mechanical ventilation for respiratory failure. Chest 128, 561S (2005).

    Article  PubMed  Google Scholar 

  41. 41. H. Freise, U. B. Bruckner, and H. U. Spiegel, Animal models of sepsis. J Invest Surg 14, 195 (2003)

    Article  Google Scholar 

  42. 42. C. W. Chow, M. T. Herrera Abreu, T. Suzuki, and G. P. Downey, Oxidative stress and acute lung injury. Am J Respir Cell Mol Biol 29, 427 (2003).

    Article  PubMed  CAS  Google Scholar 

  43. 43. M. P. Fink, Role of reactive oxygen and nitrogen species in acute respiratory distress syndrome. Curr Opin Crit Care 8, 6 (2002).

    Article  PubMed  Google Scholar 

  44. 44. C. M. Doerschuk, W. M. Quinlan, N. A. Doyle, D. C. Bullard, D. Vestweber, M. L. Jones, F. Takei, P. A. Ward, and A. L. Beaudet, The role of P-selectin and ICAM-1 in acute lung injury as determined using blocking antibodies and mutant mice. J Immunol 157, 4609 (1996).

    PubMed  CAS  Google Scholar 

  45. 45. M. Hu, Q. Du, I. Vancurova, X. Lin, E. J. Miller, H. H. Simms, and P. Wang, Proapoptotic effect of curcumin on human neutrophils: Activation of the p38 mitogen-activated protein kinase pathway. Crit Care Med 33, 2571 (2005).

    Article  PubMed  CAS  Google Scholar 

  46. 46. A. Literat, F. Su, M. Norwicki, M. Durand, R. Ramanathan, C.A. Jones, P. Minoo, and K. Y. Kwong, Regulation of pro-inflammatory cytokine expression by curcumin in hyaline membrane disease (HMD). Life Sci 70, 253 (2001).

    Article  PubMed  CAS  Google Scholar 

  47. 47. L. Cohn, J. A. Elias, and G. L. Chupp, Asthma: Mechanisms of disease persistence and progression. Annu Rev Immunol 22, 789 (2004).

    Article  PubMed  CAS  Google Scholar 

  48. 48. J. A. Elias, C. G. Lee, T. Zheng, B. Ma, R. J. Homer, and Z. Zhu, New insights into the pathogenesis of asthma. J Clin Invest 111, 291 (2003).

    Article  PubMed  CAS  Google Scholar 

  49. 49. B. Kay, S. Phipps, and D. S. Robinson, A role for eosinophils in airway remodelling in asthma. Trends Immunol 25, 477 (2004).

    Article  PubMed  CAS  Google Scholar 

  50. 50. G. M. Walsh, M. Al-Rabia, M. G. Blaylock, D. W. Sexton, C. J. Duncan, and A. Lawrie, Control of eosinophil toxicity in the lung. Curr Drug Targets Inflamm Allergy 4, 481 (2005).

    Article  PubMed  CAS  Google Scholar 

  51. 51. A. Sher, R. L. Coffman, S. Hieny, P. Scott, and A. W. Cheever, Interleukin-5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni. Proc Natl Acad Sci USA. 87, 61 (1990).

    Article  PubMed  CAS  Google Scholar 

  52. 52. T. T. Kung, D. M. Stelts, J. A. Zurcher, G. K. Adams 3rd, R. W. Egan, W. Kreutner, A. S. Watnick, H. Jones, and R. W. Chapman, Involvement of IL-5 in a murine model of allergic pulmonary inflammation, prophylactic and therapeutic effect of an anti-IL-5 antibody. Am J Respir Cell Mol Biol 13, 360 (1995).

    PubMed  CAS  Google Scholar 

  53. 53. M. J. Leckie, Anti-interleukin-5 monoclonal antibodies: Preclinical and clinical evidence in asthma models. Am J Respir Med 2, 245 (2003).

    PubMed  CAS  Google Scholar 

  54. 54. G. M. Walsh, Novel therapies for asthma: Advances and problems. Curr Pharm Des 11, 3027 (2005).

    Article  PubMed  CAS  Google Scholar 

  55. 55. G. Caramori, K. Ito, and I. M. Adcock, Targeting Th2 cells in asthmatic airways. Curr Drug Targets Inflamm Allergy 3(3), 243–255 (2004).

    Article  PubMed  CAS  Google Scholar 

  56. 56. M. Ichinose and P. J. Barnes, Cytokine-directed therapy in asthma. Curr Drug Targets Inflamm Allergy 3, 263 (2004).

    Article  PubMed  CAS  Google Scholar 

  57. 57. J. E. Pease, Asthma, allergy and chemokines. Curr Drug Targets 7, 3 (2006).

    Article  PubMed  CAS  Google Scholar 

  58. 58. T. Kobayashi, S. Hashimoto, and T. Horie, Curcumin inhibition of Dermatophagoides farinea-induced interleukin-5 (IL-5) and granulocyte macrophage-colony stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics. Biochem Pharmacol 54, 819 (1997).

    Article  PubMed  CAS  Google Scholar 

  59. 59. Y. Hu, J. Peng, D. Feng, L. Chu, X. Li, Z. Jin, Z. Lin, and Q. Zeng, Role of extracellular signal-regulated kinase, p38 kinase, and activator protein-1 in transforming growth factor-beta1-induced alpha smooth muscle actin expression in human fetal lung fibroblasts in vitro. Lung 84, 33 (2006).

    Article  CAS  Google Scholar 

  60. 60. Y. Moon, W. C. Glasgow, and T. E. Eling, Curcumin suppresses interleukin-1β-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways. J Pharmaco. Ex. The. 315, 788 (2005).

    CAS  Google Scholar 

  61. 61. C. T. Shun, S. K. Lin, C. Y. Hong, S. H. Kok, Y. H. Juan, C. C. Wang, M. C. Hsu, C. M. Liu, C.-C., Chemokine ligand 2 gene expression in nasal polyp fibroblasts, possible implication in the pathogenesis of nasal polyposis. Ann Otol Rhinol Laryngol 114, 879 (2005).

    PubMed  Google Scholar 

  62. 62. J. Hong, J., M. Bose, J. Ju, J. H. Ryu, X. Chen, S. Sang, M. J. Lee, and C. S. Yang, Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: Effects on cytosolic phospholipase A(2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis 25, 1671 (2004).

    Article  PubMed  CAS  Google Scholar 

  63. 63. Y. Abe, S. Hashimoto, and T. Horie, Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol Res 39, 41 (1999).

    Article  PubMed  CAS  Google Scholar 

  64. 64. T. Yokoyama, H. Oono, A. Miyamoto, S. Ishiguro, and A. Nishio, Magnesium-deficient medium enhances NO production in alveolar macrophages isolated from rats. Life Sci. 72, 1247 (2003).

    Article  PubMed  CAS  Google Scholar 

  65. 65. S. K. Biswas, D. McClure, L. A. Jimenez, I. L. Megson, and I. Rahman, Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: Mechanism of free radical scavenging activity. Antioxid Redox Signal. 7, 32 (2005).

    Article  PubMed  CAS  Google Scholar 

  66. 66. W. A. Wuyts, B. M. Vanaudenaerde, L. J. Dupont, M. G. Demedts, and G. M. Verleden, Involvement of p38 MAPK, JNK, p42/p44 ERK and NF-kappaB in IL-1β-induced chemokine release in human airway smooth muscle cells. Respir Med 97, 811 (2003).

    Article  PubMed  Google Scholar 

  67. 67. W. A. Wuyts, B. M. Vanaudenaerde, L. J. Dupont, D. E. Van Raemdonck, M. G. Demedts, and G. M. Verleden, Interleukin-17-induced interleukin-8 release in human airway smooth muscle cells: Role for mitogen-activated kinases and nuclear factor-kappaB. J Heart Lung Transplant 24, 875 (2005).

    Article  PubMed  Google Scholar 

  68. 68. F. Shen, X. Fan, B. Liu, X. Jia, H. Du, B. You, M. Ye, C. Huang, and X. Shi, Overexpression of cyclin D1-CDK4 in silica-induced transformed cells is due to activation of ERKs, JNKs/AP-1 pathway. Toxicol Lett 160, 185 (2006).

    Article  PubMed  CAS  Google Scholar 

  69. 69. S. Chakraborty, M. Roy, and R. K. Bhattacharya, Prevention and repair of DNA damage by selected phytochemicals as measured by single cell gel electrophoresis. J Environ Pathol Toxicol Oncol 23, 215 (2004).

    Article  PubMed  CAS  Google Scholar 

  70. 70. D. M. Brown, D. M., P. H. Beswick, and K. Donaldson, Induction of nuclear translocation of NF-kappaB in epithelial cells by respirable mineral fibres. J Pathol 189, 258 (1999).

    Article  PubMed  CAS  Google Scholar 

  71. 71. R. P. Schins, A. McAlinden, W. MacNee, L. A. Jimenez, J. A. Ross, K. Guy, S. P. Faux, and K. Donaldson, Persistent depletion of I kappa B alpha and interleukin-8 expression in human pulmonary epithelial cells exposed to quartz particles. Toxicol Appl Pharmacol 167, 107 (2000).

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Narayanan Venkatesan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Durairaj Punithavathi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mary Babu
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Ransom Horne, Jr., Professor of Cancer Research Professor of Cancer Medicine (Biochemistry)and Chief, Cytokine Research Section Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston,, TX, 143, 77030, USA

    Bharat B. Aggarwal Ph.D.

  2. Chief and Professor National Research Laboratory of Molecular Carcinogenesis and Chemoprevention College of Pharmacy, Seoul National University, Shillim-dong, Kwanak-gu, Seoul, 151-742, South Korea

    Young-Joon Surh Ph.D.

  3. Assistant Professor Department of Biology, Texas Southern University, 3100 Cleburne Street, Houston, TX 77004, USA

    Shishir Shishodia Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer

About this chapter

Cite this chapter

Venkatesan, N., Punithavathi, D., Babu, M. (2007). PROTECTION FROM ACUTE AND CHRONIC LUNG DISEASES BY CURCUMIN. In: Aggarwal, B.B., Surh, YJ., Shishodia, S. (eds) The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol 595. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-46401-5_17

Download citation

Publish with us

Policies and ethics

Search

Navigation