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Somatic Cell Nuclei in Cloning

Strangers Traveling in a Foreign Land

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Book cover Somatic Cell Nuclear Transfer

Part of the book series: Advances in Experimental Medicine and Biology ((volume 591))

Abstract

The recent successes in producing cloned offspring by somatic cell nuclear transfer are nothing short of remarkable. This process requires the somatic cell chromatin to substitute functionally for both the egg and the sperm genomes, and indeed the processing of the transferred nuclei shares aspects in common with processing of both parental genomes in normal fertilized embryos. Recent studies have yielded new information about the degree to which this substitution is accomplished. Overall, it has become evident that multiple aspects of genome processing and function are aberrant, indicating that the somatic cell chromatin only infrequently manages the successful transition to a competent surrogate for gamete genomes. This review focuses on recent results revealing these limitations and how they might be overcome.

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Authors and Affiliations

  1. Department of Biochemistry, The Fels Institute for Cancer Research and Molecular Biology, 3307 North Broad Street, Philadelphia, Pennsylvania, 19140, USA

    Keith E. Latham

  2. The Fels Institute for Cancer Research and Molecular Biology, Temple University Medical School, Philadelphia, Pennsylvania, USA

    Shaorong Gao & Zhiming Han

  3. National Institute of Biological Sciences, Zhongguancun Life Science Park, Beijing, China

    Shaorong Gao

Authors
  1. Keith E. Latham
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  2. Shaorong Gao
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  3. Zhiming Han
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Editor information

Editors and Affiliations

  1. Department of Animal Science, University of Missouri-Columbia, Columbia, Missouri, USA

    Peter Sutovsky Ph.D.

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© 2007 Landes Bioscience and Springer Science+Business Media

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Latham, K.E., Gao, S., Han, Z. (2007). Somatic Cell Nuclei in Cloning. In: Sutovsky, P. (eds) Somatic Cell Nuclear Transfer. Advances in Experimental Medicine and Biology, vol 591. Springer, New York, NY. https://doi.org/10.1007/978-0-387-37754-4_2

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