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Factors Affecting the Fibrillation of α-Synuclein, a Natively Unfolded Protein

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Abstract

Substantial evidence has accumulated in the last few years that the aggregation/ fibrillation of α-synuclein is a critical factor in Parkinson’s disease (PD). α-Synuclein is a major component of intracellular inclusions known as Lewy bodies which are the pathological hallmark of PD. Mutations of α-synuclein have been associated with rare cases of familial PD.

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Fink, A.L. (2006). Factors Affecting the Fibrillation of α-Synuclein, a Natively Unfolded Protein. In: Misbehaving Proteins. Springer, New York, NY. https://doi.org/10.1007/978-0-387-36063-8_12

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