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Hypoxia and Exercise pp 217–231Cite as

Red Blood Cells and Hemoglobin in Hypoxic Pulmonary Vasoconstriction

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 588))

Abstract

Nitric oxide (NO) plays an important role in the modulation of hypoxic pulmonary vasoconstriction; in turn, red blood cells (RBCs) augment HPV by hemoglobin-mediated oxidation and inactivation of NO. In addition, scavenging of reactive oxygen species by RBCs may play a role in augmentation of HPV. NO delivery and/or production by RBCs does not appear to be important in the control of pulmonary vasomotor tone. This review will discuss regulation of HPV by RBCs with an emphasis on hemoglobin-NO interactions. In addition, the review will discuss how biologic (S-nitrosation) or pharmacologic (cross-linking) modification of hemoglobin may affect pulmonary circulatory-hemoglobin interactions.

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  1. Departments of Anesthesiology and Medicine, University of Washington, Harborview Medical Center, Seattle, WA, USA

    Steven Deem

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  2. UCSD Dept Medicine, 0623 9500 Gilman Avenue, La Jolla, CA, 92093-0623

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Deem, S. (2006). Red Blood Cells and Hemoglobin in Hypoxic Pulmonary Vasoconstriction. In: Roach, R.C., Wagner, P.D., Hackett, P.H. (eds) Hypoxia and Exercise. Advances in Experimental Medicine and Biology, vol 588. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-34817-9_19

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