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Ventral and Dorsal Contributions to Hematopoiesis in Xenopus

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Hematopoietic Stem Cell Development

Part of the book series: Medical Intelligence Unit ((MIUN))

Abstract

The view that all blood derives from ventral mesoderm has been challenged in recent years. In the Xenopus embryo, it is now clear that the embryonic blood compartment, the ventral blood island (VBI), is derived from regions of the pre-gastrula embryo traditionally referred to as dorsal as well as ventral. Furthermore, recent lineage labelling studies in Xenopus, show that the adult blood lineage in the dorsal lateral plate (DLP) mesoderm arises independendy of the embryonic lineage. Thus, there appear to be three distinct sources of blood in Xenopus embryos, two giving rise to the VBI and one the DLP. Distinct origins coupled with separate migration pathways through the embryo suggest that the three populations may be independendy programmed during development. Perturbation of BMP signalling shows that all three require this signal in order to form the putative bipotential precursor of blood and endothelium, the hemangioblast. Differences between the embryonic populations and the adult lineage however have been detected with respect to retinoid signalling during gastrulation, and also with respect to specific gene responses to BMP signalling. Experimental manipulations of this model system are beginning to inform our understanding of the developmental programming of hematopoietic stem cells.

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Authors and Affiliations

  1. Institute of Genetics, University of Nottingham Queen’s Medical Centre, Nottingham, UK

    Aldo Ciau-Uitz & Maggie Walmsley

  2. The Weatherhall Institute of Molecular Medicine MRC Molecular Haematology Unit, University of Oxford John Radcliffe Hospital, Headington, Oxford, UK

    Roger Patient

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  1. Aldo Ciau-Uitz
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  2. Maggie Walmsley
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  3. Roger Patient
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Ciau-Uitz, A., Walmsley, M., Patient, R. (2006). Ventral and Dorsal Contributions to Hematopoiesis in Xenopus . In: Hematopoietic Stem Cell Development. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-33535-3_1

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