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Novel Mechanisms of Estrogen Action in the Developing Brain

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Biology of Menopause

Part of the book series: Serono Symposia USA ((SERONOSYMP))

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Abstract

Estrogen and the neurotrophins [e.g., nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin4/5, (NT-4/5)] have been implicated in the development, survival, plasticity, and aging of neurons in mammalian forebrain regions that subserve cognitive functions. Neurons in overlapping forebrain regions of both sexes coexpress estrogen and neurotrophin receptors, and they are the sites of estrogen and neurotrophin synthesis (1,2). An important question raised by these associations concerns the biological significance of receptor co-expression and the potential for interactions of their ligands.

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Authors
  1. C. Dominique Toran-Allerand
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Editors and Affiliations

  1. Biology of Aging Program, National Institute on Aging, Gateway Building, Suite 2C231, 20892-9205, Bethesda, MD, USA

    Francis L. Bellino Ph.D.

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© 2000 Springer-Verlag New York, Inc.

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Toran-Allerand, C.D. (2000). Novel Mechanisms of Estrogen Action in the Developing Brain. In: Bellino, F.L. (eds) Biology of Menopause. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-0-387-21628-7_9

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  • DOI: https://doi.org/10.1007/978-0-387-21628-7_9

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-9530-0

  • Online ISBN: 978-0-387-21628-7

  • eBook Packages: Springer Book Archive

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