As Western culture has become more aware of Eastern spiritual traditions, scientists have been increasingly interested in verifying the anecdotal claims from expert meditators regarding mindfulness practice. For almost 50 years, the practice of meditation and mindfulness has been studied byWestern neuroscientists looking to better understand its phenomenology, neurobiology, and clinical effects. In this chapter, we provide an overview of current neurobiological research on mindfulness and meditation practices, including key findings, methodological issues, and clinical implications.
The mind precedes all things, the mind dominates all things, the mind creates all things. Buddha
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Aftanas, L. I., & Golocheikine, S. A. (2005). Impact of regular meditation practice on EEG activity at rest and during evoked negative emotions. International Journal of Neuroscience, 115, 893–909.
Andresen, J. (2000). Meditation meets behavioral medicine: The story of experimental research on meditation. Journal of consciousness Studies, 7, 17–73.
Austin, J. H. (1998). Zen and the Brain: Toward an understanding of meditation and consciousness. Cambridge, MA: MIT Press.
Azari, N. P., Nickel, J., Wunderlich, G., Niedeggen, M., Hefter, H., Tellmann, L., et al. (2001). Neural correlates of religious experience. European Journal of Neuroscience, 13, 1649–1652.
Baerentsen, K. B. (2001). Onset of meditation explored with fMRI. Neuroimage, 13, S297.
Baer, R. A. (Ed). (2006). Mindfulness-based treatment approaches: Clinician’s guide to evidence base and applications. San Diego, CA: Elsevier Academic Press.
Banquet, J. P. (1973). Spectral analysis of the EEG in meditation. Elec-troencephalography and Clinical Neurophysiology, 35, 143–151.
Barnhofer, T., Duggan, D., Crane, C., Hepburn, S., Fennell, M. J., & Williams, J. M. (2007). Effects of meditation on frontal alpha-asymmetry in previously suicidal individuals. Neuroreport, 18 (7), 709–812.
Becker, D. E., & Shapiro, D. (1981). Physiological responses to clicks during zen, yoga, and TM meditation. Psychophysiology, 18(6), 694–699.
Brefczynski-Lewis, J. A., Lutz, A., Schaefer, H. S., Levinson, D. B., & Davidson, R. J. (2007). Neural correlates of attentional expertise in long-term meditation practitioners. Proceedings of the National Academy of Sciences of the USA, 104(27), 11483–11488.
Bush, G., Luu, P., & Posner, M. I. (2000). Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences, 4(6), 215–222.
Cahn, B. R., & Polich, J. (2006). Meditation states and traits: Eeg, erp, and neuroimaging studies. Psychological Bulletin, 132(2), 180–211.
Casey, K. L., Minoshima, S., Morrow, T. J., & Koeppe, R. A. (1996). Comparison of human cerebral activation pattern during cutaneous warmth, heat pain, and deep cold pain. Journal of Neurophysiology, 76(1), 571–581.
Craig, A. D., (2004). Human feelings: Why are some more aware than others? Trends in Cognitive Sciences, 8(6), 231–241.
Crespo-Facorro, B., Kim, J., Andreasen, N. C., O’Leary, D. S., Bockholt, H. J., & Magnotta, V. (2000). Insular cortex abnormalities in schizophrenia: A structural magnetic resonance imaging study of first-episode patients. Schizophrenia Research, 46(1), 35–43.
Creswell, J. D., Way, B. M., Eisenberger, N. I., & Lieberman, M. D. (2007). Neural correlates of dispositional mindfulness during affect labeling. Psychosomatic Medicine, 69(6), 560–565.
Cuthbert, B., Kriteller, J., Simons, R., Hodes, R., & Lang, P. J. (1981). Strategies of arousal control: Biofeedback, meditation, and motivation. Journal of Experimental Psychology: General, 110, 518–546.
Davidson, J. M. (1976). The physiology of meditation and mystical states of consciousness. Perspectives in Biology and Medicine, 19, 345–379.
Davidson, R. J., Kabat-Zinn, J., Schumacher, J., Rosenkranz, M., Muller, D., Santorelli, S. F., et al. (2003). Alterations in brain and immune function produced by mindfulness meditation. Psychosomatic Medicine, 65(4), 564–570.
Delmonte, M. M. (1984). Physiological responses during meditation and rest. Biofeedback and Self Regulation, 9, 181–200.
Delmonte, M. M. (1985). Effects of expectancy on physiological responsivity in novice meditators. Biological Psychology, 21, 107–121.
Dunn, B. R., Hartigan, J. A., & Mikulas, W. L. (1999). Concentration and mindfulness meditations: Unique forms of consciousness? Applied Psychophysiology and Biofeedback, 24(3), 147–165.
Farb, N. A. S., Segal, Z. V., Mayberg, H. M., Bean, J., McKeon, D., Fatima, Z., & Anderson, A. K. (2007). Attending to the present: mindfulness reveals distinct neural modes of self-reference. Social Cognitive and Affective Neuroscience, 2 (4), 313–322.
Goleman, D. J., & Schwartz, G. E. (1976). Meditation as an intervention in stress reactivity. Journal of Consulting and Clinical Psychology, 44(3), 456–466.
Hirai, T. (1974). Psychophysiology of Zen. Tokyo: Igaku Shoin.
Holzel, B. K., Ott, U., Hempel, H., Hackl, A., Wolf, K., Stark, R., et al. (2007). Differential engagement of anterior cingulate and adjacent medial frontal cortex in adept meditators and non-meditators. Neuroscience Letters, 421(1), 16–21.
Jacobs, G.D., & Lubar, J. F. (1989). Spectral analysis of the central nervous system effects of the relaxation response elicited by autogenic training. Behavioral Medicine, 15, 125–132.
Jain, S., Shapiro, S. L., Swanick, S., Roesch, S. C., Mills, P. J., Bell, I., et al. (2007). A randomized controlled trial of mindfulness meditation versus relaxation training: Effects on distress, positive states of mind, rumination, and distraction. Annals of Behavioral Medicine, 33(1), 11–21.
Jevning, R., Wallace, R. K., & Beidebach, M. (1992). The physiology of meditation: A review. A wakeful hypometabolic integrated response. Neuroscience and Biobehavioral Reviews, 16, 415–424.
Jha, A. P., Krompinger, J., & Baime, M. J. (2007). Mindfulness training modifies subsystems of attention. Cognitive Affective and Behavioral Neurosciences, 7 (2), 109–119.
Kasamatsu, A., & Hirai, T. (1966). An electroencephalographic study on the Zen meditation (zazen). Folia Psychiatrica et Neurologica Japonica, 20, 315–336.
Kasamatsu, A., & Hirai, T. (1973). An electroencephalographic study on the Zen meditation (zazen). Journal of the American Institute of Hypnosis, 14, 107–114.
Lazar, S. W., Bush, G., Gollub, R. L., Fricchione, G. L., Khalsa, G., & Benson, H. (2000). Functional brain mapping of the relaxation response and meditation. NeuroReport, 11, 1581–1585.
Lazar, S. W. (2005). Mindfulness research. In R. D. Siegel, P. R. Fulton, (Eds.), Mindfulness and psychotherapy (pp. 220–238) New York, NY, US: Guilford Press.
Lazar, S. W., Kerr, C., Wasserman, R. J., Gray, J. R., Greve D., Treadway, M. T. et al., (2005). Meditation experience is associated with increased cortical thickness. Neuroreport 16(17):1893–1897.
Lehmann, D., Faber, P. L., Achermann, P., Jeanmonod, D., Gianotti, L. R., & Pizzagalli, D. (2001). Brain sources of EEG gamma frequency during volitionally meditation-induced, altered states of consciousness, and experience of the self. Psychiatry Research, 108(2), 111–121.
Liotti, M., Mayberg, H. S., McGinnis, S., Brannan, S. L., & Jerabek, P. (2002). Unmasking disease-specific cerebral blood flow abnormalities: Mood challenge in patients with remitted unipolar depression. American Journal of Psychiatry, 159(11), 1830–1840.
Lutz, A., Greischar, L. L., Rawlings, N. B., Ricard, M., & Davidson, R. J. (2004). Long-term meditators self-induce high-amplitude gamma synchrony during mental practice. Proceeding of the National Academy of Sciences of the USA, 101(46), 16369–16373.
Murphy, M., Donovan, S., & Taylor, E. (1997). The physical and psychological effects of meditation: A review of contemporary research 1991–1996. Petaluma, CA: Institute of Noetic Sciences.
Newberg, A., Alavi, A., Baime, M., Pourdehnad, M., Santanna, J., & d’Aquili, E. (2001). The measurement of regional cerebral blood flow during the complex cognitive task of meditation: a preliminary SPECT study. Psychiatry Research, 106 (2), 113–122.
Pagano, R. R., & Warrenburg, S. (1983). Meditation: In search of a unique effect. In R. J. Davidson, G. E. Schwartz, & D. Shapiro (Eds.), Consciousness and self-regulation (Vol. 3, pp. 152–210). New York: Plenum Press.
Pagnoni, G., & Cekic M. (2007) Age effects on gray matter volume and attentional performance in Zen meditation. Neurobiol Aging , 28 (10),1623–7.
Paus, T. (2001). Primate anterior cingulate cortex: Where motor control, drive and cognition interface. Nature Reviews Neuroscience, 2(6), 417–424.
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003). Neurobiology of emotion perception ii: Implications for major psychiatric disorders. Biological Psychiatry, 54(5), 515–528.
Reiman, E. M., Lane, R. D, Ahern, G. L., & Scwartz, G. E. (1997). Neuroanatomical correlates of externally and internally generated human emotion. American Journal of Psychiatry, 154, 918–925.
Ritskes, R., Ritskes-Hoitinga, M., Stodkilde-Jorgensen, H., Baerentsen, K., & Hartman, T. (2003). MRI scanning during Zen meditation: The picture of enlightenment? Constructivism in the Human Sciences, 8, 85–90.
Schuman, M. (1980). The psychophysiological model of meditation and altered states of consciousness: A critical review. In J. M. Davidson & R. J. Davidson (Eds.), The psychobiology of consciousness (pp. 333–378). New York: Plenum Press.
Shapiro, K. L., Arnell, K. A., & Raymond, J. E. (1997). The attentional blink. Trends in Cognitive Sciences, 1, 291–296.
Shin, L. M., Dougherty, D. D., Orr, S. P., Pitman, R. K., Lasko, M., Macklin, M. L., et al. (2000). Activation of anterior paralimbic structures during guilt-related script-driven imagery. -Biological Psychiatry, 48(1), 43–50.
Slagter, H. A., Lutz, A., Greischar, L. L., Francis, A. D., Nieuwenhuis, S., Davis, J. M., et al. (2007). Mental training affects distribution of limited brain resources. PLoS Biology, 5(6), e138.
Taneli, B., & Krahne, W. (1987). EEG change of transcendental meditation practitioners. Advances in Biological Psychiatry, 16, 41–71.
Valentine, E. R., & Sweet, P. L. G. (1999) Meditation and attention: a comparison of the effects of concentrative and mindfulness meditation on sustained attention. Mental Health, Religion & Culture, 2(1), 59–70.
West, M. A. (1979). Meditation. British Journal of Psychiatry, 135, 457–467.
Woolfolk, R. L. (1975). Psychophysiological correlates of meditation. Archives of General Psychiatry, 32, 1326–1333.
Wright, I.C., Rabe-Hesketh, S., Woodruff, P.W.R., David, A.S., Murray, R.M., Bullmore, E.T. (2000). Regional brain structure in schizophrenia: A meta-analysis of volumetric MRI studies. American Journal of Psychiatry, 157, 16–25.
Wright, P., He, G., Shapira, N. A., Goodman, W. K., & Liu, Y. (2004). Disgust and the insula: fMRI responses to pictures of mutilation and contamination. Neuroreport, 15(15), 2347–2351.
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Treadway, M.T., Lazar, S.W. (2009). The Neurobiology of Mindfulness. In: Didonna, F. (eds) Clinical Handbook of Mindfulness. Springer, New York, NY. https://doi.org/10.1007/978-0-387-09593-6_4
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