Skip to main content
SpringerLink
Log in
Book cover

Signal Transduction in the Cardiovascular System in Health and Disease pp 229–247Cite as

Identifying the Cellular and Molecular Events Associated with the Divergent Phenotypes of Cardiac Hypertrophy

  • Chapter

  • 883 Accesses

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 3))

Abstract

Following the imposition of a hemodynamic load, the primary adaptive response of the heart involves an increase in size of individual cardiac myocytes in the absence of cell division. This process is characterized as cardiac hypertrophy and the pattern of individual myocyte growth is directly influenced by the nature of the hemodynamic load. Cardiac hypertrophy can be classified as either physiological or pathological and their disparate phenotypes are related in part to a divergent pattern of peptide growth factor expression. Gq-mediated recruitment of Ca2+- and PKC-dependent signaling pathways may primarily be implicated in the progression of pathological hypertrophy characterized by a concentric pattern of remodeling. By contrast, recruitment of the phosphatidylinositol 3-kinase isoform p110α may selectively participate in the physiological growth of cardiac myocytes. However, there exists evidence to suggest that Ca2+-dependent pathways may also play a supporting role in physiological cardiac hypertrophy. Thus, this review will provide a comprehensive analysis of the morphological, cellular, and molecular phenotypes of physiological and pathological cardiac hypertrophy and explore the relative contribution of Gq- and phosphatidylinositol 3-kinase-dependent pathways.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adams, J.W., Sakata, Y., Davis, M.G., Sah, V., Wang, Y., Ligget, S.B., Chein, K.R., Brown, J.H., and Dorn, G.W., II. 1998. Enhanced Gαq signalling: A common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proc. Natl. Acad. Sci. USA 95:10140-10145.

    Article  CAS  PubMed  Google Scholar 

  • Anversa, P., Levicky, V., Beghi, C., McDonald, S.L., and Kikkawa, Y. 1983. Morphometry of exercise-induced right ventricular hypertrophy in the rat. Circ. Res. 52:57-64.

    CAS  PubMed  Google Scholar 

  • Anversa, P., Ricci, R., and Olivetti, G. 1986. Quantitative structural analysis of the myocardium during physiological growth and induced cardiac hypertrophy: a review. J. Am. Coll. Cardiol. 7:1140-1149.

    CAS  PubMed  Google Scholar 

  • Black, F.M., Packer, S.E., Parker, T.G., Michael, L.H., Roberts, R., Schwartz, R.J., and Schneider, M.D. 1991. The vascular smooth muscle α-actin gene is reactivated during cardiac hypertrophy provoked by load. J. Clin. Invest. 79:970-977.

    Google Scholar 

  • Braunwald, E. 1992. Heart Disease: A Textbook of Cardiovascular Medicine (4th ed.). Saunders, Philadelphia.

    Google Scholar 

  • Braz, J., Gregory, K., Pathak, A., Zhao, W., Sahin, B., Klevitsky, R., Kimball, T.F., Lorenz, J.N., Nairn, A.C., Liggett, S.B., Bodi, I., Wang, S., Schwartz, A., Lakatta, E.G., DePaoli-Roach, A.A., Robbins, J., Hewett, T.E., Bibb, J.A., Westfall, M.V., Kranias, E.G., and Molkentin, J.D. 2004. PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nature Med. 10:248-254.

    Article  CAS  PubMed  Google Scholar 

  • Calderone, A., Takahashi, N., Izzo, N.J., Thaik, C.M., and Colucci, W.S. 1995. Pressure- and volume-induced left ventricular hypertrophies are associated with distinct myocyte phenotypes and differential induction of peptide growth factor mRNAs. Circulation 92:2385-2390.

    CAS  PubMed  Google Scholar 

  • Calderone, A., Takahashi, N., Thaik, C., and Colucci, W.S. 1998. Atrial natriuretic peptide, nitric oxide and cGMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts. J. Clin. Invest. 101:812-818.

    Article  CAS  PubMed  Google Scholar 

  • Calderone, A., Abdelaziz, N., Colombo, F., Schreiber, K.L., and Rindt, H. 2000. A farnesyltrans-ferase inhibitor attenuates cardiac myocyte hypertrophy and gene expression. J. Mol. Cell. Car-diol. 32:1127-1140.

    Article  CAS  Google Scholar 

  • Calderone, A., Murphy, R.J.L., Lavoie, J., Colombo, F., and Beliveau, L. 2001. TGF-β1 and prepro-ANP mRNAs are differentially regulated in exercise-induced cardiac hypertrophy. J. Appl. Physiol. 91:771-776.

    CAS  PubMed  Google Scholar 

  • Colomer, J.M., and Means, A.R. 2000. Chronic elevation of calmodulin in the ventricles of trans-genic mice increases the autonomous activity of calmodulin-dependent protein kinase II, which regulates atrial natriuretic factor gene expression. Mol. Endocrinol. 14:1125-1136.

    Article  CAS  PubMed  Google Scholar 

  • Crackower, M.A., Oudit, G.Y., Kozieradzki, I., Sarao, R., Sun, H., Sasaki, T., Irie-Sasaki, J., Sah, R., Cheng, H.-Y.M., Rybin, V.O., Lembo, G., Fratta, L., Oliveira-dos-Santos, A.J., Benovic, J.L., Kahn, C.R., Izumo, S., Steinberg, S.F., Wymann, M.P., Backx, P.H., and Penninger, J.P. 2002. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signalling pathways. Cell 110:737-749.

    Article  CAS  PubMed  Google Scholar 

  • de la Bastie, D., Levitsky, D., Rappaport, L., Mercadier, J.J., Marotte, F., Wisnewsky, C., Brovkovich, V., Schwartz, K., and Lompre, A.M. 1990. Function of the sarcoplasmic reticu-lum and expression of its Ca2+ ATPase gene in pressure overload-induced cardiac hypertrophy in the rat. Circ. Res. 66:554-565.

    PubMed  Google Scholar 

  • Delaughter, M.C., Taffet, G.E., Fiorotto, M.L., Entman, M.L., and Schwartz, R.L. 1999. Local insulin-like growth factor expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice. FASEB J. 13:1923-1929.

    CAS  PubMed  Google Scholar 

  • Diffee, G.M., Seversen, E.A., Stein, T.D., and Johnson, J.A. 2003. Microarray expression analy-sis of effects of exercise training: increase in atrial MLC-1 in rat ventricles. Am. J. Physiol. 284:H830-H837.

    CAS  Google Scholar 

  • Ellmers, L.J., Knowles, J.W., Kim, H.S., Smithies, O., Maeda, N., and Cameron, V.A. 2002. Ven-tricular expression of natriuretic peptides in Npr1(-/-) mice with cardiac hypertrophy and fibro-sis. Am. J. Physiol. 283:H707-H714.

    CAS  Google Scholar 

  • Eto, Y., Yonekura, K., Sonoda, M., Arai, N., Sata, M., Sugiura, S., Takenaka, K., Gualberto, A., Hixon, M.L., Wagner, M.W., and Aoyagi, T. 2000. Calcineurin is activated in rat hearts with physiological left ventricular hypertrophy induced by voluntary exercise training. Circulation 101:2134-2137.

    CAS  PubMed  Google Scholar 

  • Geenen, D.L., Malhotra, A., and Buttrick, P.M. 1996. Angiotensin receptor 1 blockade does not prevent physiological cardiac hypertrophy in the adult rat. Am. J. Physiol. 81:816-821.

    CAS  Google Scholar 

  • Gerdes, A.M., Campbell, S.E., and Hilbelink, D.R. 1988. Structural remodelling of cardiac my-ocytes in rats with arteriovenous fistula. Lab. Invest. 59:857-861.

    CAS  PubMed  Google Scholar 

  • Grossman, W., Jones, D., and McLaurin, L.P. 1975. Wall stress and patterns of hypertrophy in the human left ventricle. J. Clin. Invest. 56:56-64.

    Article  CAS  PubMed  Google Scholar 

  • Hainsey, T., Csiszar, A., Sun, S., and Edwards, J.G. 2002. Cyclosporin A does not block exercise-induced cardiac hypertrophy. Med Sci. Sports. Exerc. 34:1249-1254.

    Article  CAS  Google Scholar 

  • Huang, C.-H., Hao, L.-Y., and Buetow, D.E. 2002. Insulin-like growth factor-induced hypertrophy of cultured adult rat cardiomyocytes is L-type calcium-channel-dependent. Mol. Cell. Biochem. 231:51-59.

    Article  CAS  PubMed  Google Scholar 

  • Iemitsu, M., Miyauchi, T., Maeda, S., Sakai, S., Kobayashi, T., Fujii, N., Miyazaki, H., Matsuda, M., and Yamaguchi, I. 2001. Physiological and pathological cardiac hypertrophy induce different molecular phenotypes in the rat. Am. J. Physiol. 281:R2029-R2036.

    Google Scholar 

  • Ito, H., Hiroe, M., Hirata, Y., Fujisaki, H., Adachi, S., Akimoto, H., Ohta, Y., and Marumo, F. 1994. Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemody-namic overload. Circulation 89:2198-2203.

    CAS  PubMed  Google Scholar 

  • Izumo, S., Nadal-Ginard, B., and Mahdavi, V. 1988. Proto-oncogene induction and reprogram-ming of the cardiac gene expression produced by pressure-overload. Proc. Natl. Acad. Sci. USA 85:339-343.

    Article  CAS  PubMed  Google Scholar 

  • Jin, H., Yang, R., Li, W., Ryan, A., Ogasawara, A.K., Peborgh, J.V., and Paoni, N.F. 2000. Effects of exercise training on cardiac function gene expression, and apoptosis in rats. Am. J. Physiol. 279:H2994-H3002.

    CAS  Google Scholar 

  • Katz, A.M. 1990. Cardiomyopathy of overload: A major determinant of prognosis in congestive heart failure. N. Engl. J. Med. 322:100-110.

    Article  CAS  PubMed  Google Scholar 

  • Kee, H.J., Sohn, I.S., Nam, K.I., Park, J.E., Qian, Y.R., Yin, Z., Ahn, Y., Jeong, M.H., Bang, Y.J., Kim, N., Kim, J.K., Epstein, J.A., and Kook, H. 2006. Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II and aortic banding. Circulation 113:51-59.

    Article  CAS  PubMed  Google Scholar 

  • Kinugawa, S., Tsutsui, H., Ide, T., Nakamura, R., Arimura, K., Egashira, K., and Takeshita, A. 1999. Positive inotropic effect of insulin-like growth factor-1 on normal and failing cardiac myocytes. Cardiovasc. Res. 43:157-164.

    Article  CAS  PubMed  Google Scholar 

  • Konhilas, J.P., Maass, A.H., Luckey, S.W., Stauffer, B.L., Olson, E.N., and Leinwand, L.A. 2004. Sex modifies exercise and cardiac adaptation in mice. Am. J. Physiol. 287:H2768-H2776.

    CAS  Google Scholar 

  • Li, Q., Li, B., Wang, X., Leri, A., Jana, K., Lui, Y., Kajstura, J., Baserga, R., and Anversa, P. 1997. Overexpression of insulin-like growth factor-1 in mice protects from death after infarction, at-tenuating ventricular dilatation, wall stress, and cardiac hypertrophy. J. Clin. Invest. 100:1991-1999.

    Article  CAS  PubMed  Google Scholar 

  • Lijnen, P., and Petrov, V. 1999. Renin-angiotensin system, hypertrophy and gene expression in cardiac myocytes. J. Mol. Cell. Cardiol. 31:949-970.

    Article  CAS  PubMed  Google Scholar 

  • Lim, H.W., De Windt, L.J., Steiberg, L., Taigen, T., Witt, S.A., Kimball, T.R., and Molkentin, J.D. 2000. Calcineurin expression, activation, and function in cardiac pressure-overload hypertrophy. Circulation 101:2431-2437.

    CAS  PubMed  Google Scholar 

  • Luo, J., McMullen, J.R., Sobkiw, C.L., Zhang, L., Dorfman, A.L., Sherwood, M.C., Logsdon, M.N., Horner, J.W., DePinho, R.A., Izumo, S., and Cantley, L.C. 2005. Class 1A phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy. Mol. Cell. Biol. 25:9491-9502.

    Article  CAS  PubMed  Google Scholar 

  • Malhotra, R., Sadoshima, J., Brosius, F.C. 3rd , and Izumo, S. 1999. Mechanical stretch and an-giotensin II differentially upregulate the renin-angiotensin system in cardiac myocytes in vitro. Circ. Res 85:137-146.

    Google Scholar 

  • Marino, T.A., Kent, R.L., Uboh, C.E., Fernandez, E., Thompson, E.W., and Cooper, G., 1985. Structural analysis of pressure versus volume overload hypertrophy of cat right ventricle. Am. J. Physiol. 249:H371-H379.

    CAS  PubMed  Google Scholar 

  • Masashi, A., Matsui, H., and Periasamy, M. 1994. Sarcoplasmic reticulum gene expression in cardiac hypertrophy and heart failure. Circ. Res. 64:555-564.

    Google Scholar 

  • Matthews, K.G., Devlin, G.P., Conaglen, J.V., Stuart, S.P., Mervyn Aitken, W., and Bass, J.J. 1999. Changes in IGFs in cardiac tissue following myocardial infarction. J. Endocrinol. 163:433-445.

    Article  CAS  PubMed  Google Scholar 

  • Mazzolai, L., Nussberger, J., Aubert, J.F., Brunner, D.B., Gabbiani, G., Bruner, H.R., and Pedrazzini, T. 1998. Blood pressure-independent cardiac hypertrophy induced by locally activated renin-angiotensin system. Hypertension 31:1324-1330.

    CAS  PubMed  Google Scholar 

  • McMullen, J., Shioi, T., Zhang, L., Tarnavaski, O., Sherwood, M.C., Kang, P.M., and Izumo, S. 2003. Phosphoinositide 3-kinase (p110α) plays a critical role for the induction of physiological, but not pathological cardiac hypertrophy. Proc. Natl. Acad. Sci. USA 100:12355-12360.

    Article  CAS  PubMed  Google Scholar 

  • McMullen, J., Shioi, T., Huang, W.-Y., Zhang, L., Tarnavaski, O., Bisping, E., Schinke, M., Kong, S., Sherwood, M.C., Brown, J., Riggi, L., Kang, P.M., and Izumo, S. 2004. The insulin-like growth factor 1 receptor induces physiological heart growth via the phosphoinositide 3-kinase (p110α) pathway. J. Biol. Chem. 279:4782-4793.

    Article  CAS  PubMed  Google Scholar 

  • Mercadier, J.J., Lompre, A.M., Wisnewsky, C., Samuel, J.L., Bercovici, J., Swynghedauw, B., and Schwartz, K. 1981. Myosin isoenzymatic changes in several models of cardiac hypertrophy. Circ. Res. 49:525-532.

    CAS  PubMed  Google Scholar 

  • Modesti, P.A., Vanni, S., Bertolozzi, I., Cecioni, I., Polidori, G., Paniccia, R., Bandinelli, B., Perna, A., Liguori, P., Boddi, M., Galanti, G., and Serneri, G.G.N. 2000. Early sequence of cardiac adaptations and growth factor formation in pressure- and volume-overload hypertrophy. Am. J. Physiol. 279:H976-H985.

    CAS  Google Scholar 

  • Mohabir, R., Young, S.D., and Strosberg, A.M. 1994. Role of angiotensin in pressure overload-induced hypertrophy in rats: effects of angiotensin-converting enzyme inhibitors, an AT1 recep-tor antagonist, and surgical reversal. J. Cardiovasc. Pharmacol. 23:291-299.

    Article  CAS  PubMed  Google Scholar 

  • Molkentin, J.D., Lu, J.-R., Antos, C.L., Robbins, J., Grant, S.R., and Olson, E.N. 1998. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93:215-228.

    Article  CAS  PubMed  Google Scholar 

  • Moore, R.L., Musch, T.I., Yelamarty, R.V., Scaduto, R.C., Jr., Semanchick, A.M., Elensky, M., and Cheung, J.Y. 1993. Chronic exercise alters contractility and morphology of isolated cardiac myocytes. Am. J. Physiol. 264: C1180-C1189.

    CAS  PubMed  Google Scholar 

  • Morkin, E. 1970. Postnatal muscle fiber assembly: localization of newly synthesized myofibrillar proteins. Science 167:1499-1501.

    Article  CAS  PubMed  Google Scholar 

  • Nadal-Ginard, B., and Mahdavi, V. 1989. Molecular basis of cardiac performance: plasticity of the myocardium generated through protein isoform switches. J. Clin. Invest. 84:1693-1700.

    Article  CAS  PubMed  Google Scholar 

  • Naga Prasad, S.V., Esposito, G., Mao, L., Koch, W.J., and Rockman, H.A. 2000. Gβγ-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy. J. Biol. Chem. 275:4693-4698.

    Article  CAS  PubMed  Google Scholar 

  • Obata, K., Nagata, K., Iwase, M., Odashima, M., Nagasaka, T., Izawa, H., Murohara, T., Yamada, Y., and Yokota, M. 2005. Overexpression of calmodulin induces cardiac hypertrophy by a calcineurin-dependent pathway. Biochem. Biophys. Res. Commun. 338:1299-1305.

    Article  CAS  PubMed  Google Scholar 

  • Paradis, P., Dali-Youcef, N., Paradis, F.W., Thibault, G., and Nemer, M. 2000. Overexpression of angiotensin II type 1 receptor in cardiomyocytes induced cardiac hypertrophy and remodelling. Proc. Natl. Acad. Sci. USA 97:931-936.

    Article  CAS  PubMed  Google Scholar 

  • Parker, T.G., Packer, S.E., and Schneider, M.D. 1990. Peptide growth factors can provoke fetal contractile gene expression in rat cardiac myocytes. J. Clin. Invest. 85:507-514.

    Article  CAS  PubMed  Google Scholar 

  • Redaelli, G., Malhotra, A., Li, B., Li, P., Sonneblick, E.H., Hofmann, P.A., and Anversa, P. 1998. Effects of constitutive overexpression of insulin-like growth factor-1 on the mechanical charac-teristics and molecular properties of ventricular myocytes. Circ. Res. 82:594-603.

    CAS  PubMed  Google Scholar 

  • Rockman, H.A., Wachhorst, S.P., Mao, L., and Ross, J., Jr. 1994. ANG II receptor blockade pre-vents ventricular hypertrophy and ANF gene expression with pressure overload in mice. Am. J. Physiol. 266:H2468-H2475.

    CAS  PubMed  Google Scholar 

  • Rothermel, B.A., Vega, R.B., Yang, J., Wu, H., Bassel-Duby, R., and Williams, R.S. 2000. A pro-tein encoded within the down syndrome critical region is enriched in striated muscles and in-hibits calcineurin signalling. J. Biol. Chem. 275:8719-8725.

    Article  CAS  PubMed  Google Scholar 

  • Rothermel, B.A., McKinsey, T.A., Vega, R.B., Nicol, R.L., Mammen, P., Yang, J., Antos, C.L., Shelton, J.M., Bassel-Duby, R., Olson, E.N., and Williams, R.S. 2001. Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo. Proc. Natl. Acad. Sci. USA 98:3328-3333.

    Article  CAS  PubMed  Google Scholar 

  • Ruzicka, M., Yuan, B., and Leenen, F.H. 1994. Effects of enalapril versus losartan on regression of volume overload-induced cardiac hypertrophy in rats. Circulation 90:484-491.

    CAS  PubMed  Google Scholar 

  • Ruzicka, M., Skarda, V., and Leenen, F.H.H. 1995. Effects of ACE inhibitors on circulating ver-sus cardiac angiotensin II in volume overload induced cardiac hypertrophy in rats. Circulation 92:3568-3573.

    CAS  PubMed  Google Scholar 

  • Sadoshima, J., and Izumo, S. 1993. Molecular characterization of angiotensin II-induced hypertro-phy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ. Res. 73:413-423.

    CAS  PubMed  Google Scholar 

  • Scheinowitz, M., Kessler-Icekson, G., Freimann, S., Zimmerman, R., Schaper, W., Golomb, E., Savion, N., and Eldar, M. 2003. Short- and long-term swimming exercise training increases myocardial insulin-like growth factor-1 gene expression. Growth Hormone IGF Res. 13:19-25.

    Article  CAS  Google Scholar 

  • Schiaffino, S., Samuel, J.L., Sassoon, D., Lompre, A.M., Garner, I., Marotte, F., Buckingham, M., Rappaport, L., and Schwartz, K. 1989. Nonsynchronous accumulation of α-skeletal actin and β-myosin heavy chain mRNA’s during the early stages of pressure-overload induced cardiac hypertrophy demonstrated by in situ hybridization. Circ. Res. 64:937-948.

    CAS  PubMed  Google Scholar 

  • Schultz, J.E.J., Witt, S.A., Glascocj, B.J., Neiman, M.L., Reiser, P.J., Nix, S.L., Kimball, T.R., and Doetschman, T. 2002. TGF-β1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II. J. Clin. Invest. 109:787-796.

    CAS  Google Scholar 

  • Serneri, G.G.N., Boddi, M., Modesti, P.A., Cecioni, I., Coppo, M., Padeletti, L., Michelucci, A., Colella, A., and Galanti, G. 2001. Increased sympathetic activity and insulin-like growth factor-1 formation are associated with physiological hypertrophy in athletes. Circ. Res. 89:977-982.

    Article  CAS  Google Scholar 

  • Serneri, G.G.N., Modesti, P.A., Boddi, M., Cecioni, I., Paniccia, R., Coppo, M., Simonetti, I., Vanni, S., Papa, L., Bandinelli, B., Migliorini, A., Modesti, A., Maccherini, M., Sani, G., and Toscano, M. 1999. Cardiac growth factors in human hypertrophy: relations with myocardial contractility and wall stress. Circ. Res. 85:57-67.

    CAS  PubMed  Google Scholar 

  • Shioi, T., Kang, P., Douglas, P.S., Hampe, J., Yballe, C.M., Lawitts, J., Cantley, L.C., and Izumo, S. 2000. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. Cell 19:2537-2548.

    CAS  Google Scholar 

  • Shubieta, H.E., McDonough, P.M., Harris, A.N., Knowlton, K.U., Glembotski, C.C., Brown, J.H., and Chien, K.R. 1990. Endothelin induction of inositol phosphate hydrolysis, sarcomere assem-bly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocar-dial cell hypertrophy. J.Biol. Chem. 265:20555-20562.

    Google Scholar 

  • Strait, J.B., Martin, J.L., Bayer, A., Mestril, R., Eble, D.M., and Samarel, A.M. 2001. Role of protein kinase C-ε in hypertrophy of cultured neonatal rat ventricular myocytes. Am. J. Physiol. 280:H756-H766.

    CAS  Google Scholar 

  • Takeishi, Y., Ping, P., Bolli, R., Kirkpatrick, D.L., Hoit, B.D., and Walsh, R.A. 2000. Transgenic overexpression of constitutively active protein kinase C εcauses concentric cardiac hypertrophy. Circ. Res. 86:1218-1223.

    CAS  PubMed  Google Scholar 

  • Thompson, N.L., Bazoberry, F., Speir, E.H., Casscells, W., Ferrans, V.J., Flamnder, K.C., Kondaiah, P., Geiser, A.G., and Sporn, M.B. 1988. Transforming growth factor beta-1 in acute myocardial infarction in rats. Growth Factors 1:91-99.

    Article  CAS  PubMed  Google Scholar 

  • Vijayan, K., Szotek, E.L., Martin, J.L., and Samarel, A.M. 2004. Protein kinase C-α-induced hy-pertrophy of neonatal rat ventricular myocytes. Am. J. Physiol. 287:H2777-H2789.

    CAS  Google Scholar 

  • von Lewinski, D., Voss, K., Hulsmann, S., Kogler, H., and Pieske, B. 2003. Insulin-like growth factor-1 exerts Ca2+ -dependent positive inotropic effects in failing human myocardium. Circ. Res. 92:169-176.

    Article  CAS  PubMed  Google Scholar 

  • Weinberg, E.O., Lee, M.A., Weigner, M., Lindpianter, K., Bishop, S.P., Benedict, C.R., Douglas, P.S., Chafizadeh, E., and Lorell, B.H. 1997. Angiotensin AT1 receptor inhibition. Effects on hypertrophic remodelling and ACE expression in rats with pressure-overload hypertrophy due to ascending aortic stensois. Circulation 95:1592-1600.

    CAS  PubMed  Google Scholar 

  • Zak, R. 1974. Development and proliferative capacity of cardiac muscle cells. Circ. Res. 34-35 (Suppl. II):17-25.

    Google Scholar 

  • Zhang, T., Johnson, E.N., Gu, Y., Morissette, M.R., Sah, V.P., Gigena, M.S., Belke, D.D., Dillman, W.H., Rogers, T.B., Schulman, H., Ross, J., Jr., and Brown, J.H. 2002. The cardiac-specific nuclear δB isoform of Ca2+ /calmodulin dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity. J. Biol. Chem. 277:1261-1267.

    Article  CAS  PubMed  Google Scholar 

  • Zhang, T., Maier, L.S., Dalton, N.D., Miyamoto, S., Ross, J., Jr., Bers, D.M., and Brown, J.H. 2003. The δc isoform of CaMKII is activated in cardiac hypertrophy and induces dilated car-diomyopathy and heart failure. Circ. Res. 92:912-919.

    Article  CAS  PubMed  Google Scholar 

  • Zhu, W., Zou, Y., Shiojima, I., Kudoh, S., Aikawa, R., Hayashi, D., Mizukami, M., Toko, H., Shibasaki, F., Yazaki, Y., Nagai, R., and Komuro, I. 2000. Ca2+ /calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy. J. Biol. Chem. 275:15239-15245.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Département de Physiologie, Université de Montréal, Montréal, QC, Canada

    Angelino Calderone

  2. The Montreal Heart Institute, Montréal, QC, Canada

    Angelino Calderone

Authors
  1. Angelino Calderone
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Medicine, University of Montreal and Research Centre of the Centre Hospitalier de l’ Universite de Montreal, Montreal, PQ, H1W 4A4, Canada

    Ashok K. Srivastava

  2. Department of Physiology Faculty of Medicine, University of Montreal, Montreal, PQ, H3C3J7, Canada

    Madhu B. Anand-Srivastava

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Calderone, A. (2008). Identifying the Cellular and Molecular Events Associated with the Divergent Phenotypes of Cardiac Hypertrophy. In: Srivastava, A.K., Anand-Srivastava, M.B. (eds) Signal Transduction in the Cardiovascular System in Health and Disease. Advances in Biochemistry in Health and Disease, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-09552-3_12

Download citation

Publish with us

Policies and ethics

Search

Navigation