Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Sirvent JM, Torres A, Vidaur L, Armengol J, de Battle J, Bonet A (2000) Tracheal colonisation within 24 h of intubation in patients with head trauma: risk factor for developing early-onset ventilator-associated pneumonia. Intensive Care Med 26:1369–1372
Sirvent JM, Torres A, El-Ebiary M, Castro P, de Battle J, Bonet A (1997) Protective effect of intravenously administered cefuroxime against nosocomial pneumonia in patients with structural coma. Am J Respir Crit Care Med 155:1729–1734
Stoutenbeek CP, van Saene HKF, Miranda DR, Zandstra DF (1984) The effect of selective decontamination of the digestive tract on colonization and infection rate in multiple trauma patients. Intensive Care Med 10:185–192
van Saene HKF, Petros AJ, Ramsay G, Baxby D (2003) All great truths are iconoclastic: selective decontamination of the digestive tract moves from heresy to level 1 truth. Intensive Care Med 29:677–690
Abele-Horn M, Dauber A, Bauernfeind A, Russwurm W, Seyfarth-Metzger I, Gleich P, Ruckdeschel G (1997) Decrease in nosocomial pneumonia in ventilated patients by selective oropharyngeal decontamination (SOD). Intensive Care Med 23:1878–1895
Aerdts SJA, van Dalen R, Clasener HAL, Festen J, van Lier HJJ, Vollaard EJ (1991) Antibiotic prophylaxis of respiratory tract infection in mechanically ventilated patients. A prospective, blinded, randomized trial of the effect of a novel regimen. Chest 100:783–791
Arnow PA, Caradang GC, Zabner R, Irwin ME (1996) Randomized controlled trial of selective decontamination for prevention of infections following liver transplantation. Clin Infect Dis 22:997–1003
Barret JP, Jeschke MG, Herndon DN (2001) Selective decontamination of the digestive tract on severely burned pediatric patients. Burns 27:439–445
Bergmans DCJJ, Bonten MJM, Gaillard CA et al (2001) Prevention of ventilator-associated pneumonia by oral decontamination. A prospective, randomized, double-blind, placebo-controlled study. Am J Respir Crit Care Med 164: 382–388
Bion JF, Badger I, Crosby HA et al (1994) Selective decontamination of the digestive tract reduces Gram-negative pulmonary colonization but not systemic endotoxemia in patients undergoing elective liver transplantation. Crit Care Med 22:40–49
Blair P, Rowlands BJ, Lowry K, Webb H, Armstrong P, Smilie J (1991) Selective decontamination of the digestive tract: a stratified, randomized, prospective study in a mixed intensive care unit. Surgery 110:303–310
Boland JP, Sadler DL, Stewart W, Wood DJ, Zerick W, Snodgrass KR (1991) Reduction of nosocomial respiratory tract infections in the multiple trauma patients requiring mechanical ventilation by selective parenteral and enteral antisepsis regimen (SPEAR) in the intensive care (abstract). Abstracts of the 17th Congress of Chemotherapy, Berlin, nn. 0465
Bouter H, Schippers EF, Luelmo SAG, Versteegh MIM, Ros P, Guiot HFL, Frolich M, van Dissel JT (2002) No effect of preoperative selective gut decontamination on endotoxemia and cytokine activation during cardiopulmonary bypass: a randomized, placebo-controlled study. Crit Care Med 30:38–43
Brun-Buisson C, Legrand P, Rauss A et al (1989) Intestinal decontamination for control of nosocomial multiresistant gram-negative bacilli. Study of an outbreak in an intensive care unit. Ann Intern Med 110:873–881
Cerra FB, Maddaus MA, Dunn DL, Wells CL, Kostantinides NN, Lehman SL, Mann HJ (1992) Selective gut decontamination reduces nosocomial infections and length of stay but not mortality or organ failure in surgical intensive care unit patients. Arch Surg 127:163–169
de Jonge E, Schultz M, Spanjaard L, Bossuyt PPM, Vroom B, Dankert J (2003) Effects of selective decontamination of the digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. Lancet 362:1011–1016
Cal MA de la, Cerda E, Garcia-Hierro P et al (2002) Survival benefit in severely burned patients receiving selective decontamination of the digestive tract: a randomised, placebo controlled, double blind trial.Med Intens 26:152
Cockerill FR, Muller SR, Anhalt JP et al (1992) Prevention of infection in critically ill patients by selective decontamination of the digestive tract. Ann Intern Med 117:545–553
Ferrer M, Torres A, Gonzalez J et al (1994) Utility of selective decontamination in mechanically ventilated patients. Ann Intern Med 120:389–395
Finch RG, Tomlinson P, Holliday M, Sole K, Stack C, Rocker G (1991) Selective decontamination of the digestive tract (SDD) in the prevention of secondary sepsis in a medical/surgical intensive care unit (abstract). Abstracts of the 17th Congress of Chemotherapy, Berlin, no. 0471
Flaherty J, Nathan C, Kabins SA, Weinstein RA (1990) Pilot trial of selective decontamination for prevention of bacterial infection in an intensive care unit. J Infect Dis 162:1393–1397
Gastinne H, Wolff M, Delatour F, Faurisson F, Chevret S, for the French Study Group on selective decontamination of the digestive tract (1992) A controlled trial in intensive care units of selective decontamination of the digestive tract with nonabsorbable antibiotics. N Engl J Med 326:594–599
Gaussorges P, Salord F, Sirodot M, Tigaud S, Cagnin S, Gerard M, Robert D (1991) Efficacité de la décontamination digestive sur la survenue des bacteriemies nosocomiales chez les patients sous ventilation mecanique et recevant des betamimetiques. Rean Soins Intens Med Urg 7:169–174
Georges B, Mazerolles M, Decun J-F et al (1994) Decontamination digestive selective: resultats d’une etude chez le polytraumatise. Rean Urg 3:621–627
Hammond JMJ, Potgieter PD, Saunders GL, Forder AA (1992) Double-blind study of selective decontamination of the digestive tract in intensive care. Lancet 340:5–9
Hellinger WC, Yao JD, Alvarez S et al (2002) A randomized, prospective, double blinded evaluation of selective bowel decontamination in liver transplantation. Transplantation 73:1904–1909
Jacobs S, Foweraker JE, Roberts SE (1992) Effectiveness of selective decontamination of the digestive tract (SDD) in an ICU with a policy encouraging a low gastric pH. Clin Intensive Med 3:52–58
Kerver AJH, Rommes JH, Mevissen-Verhage EAE, Hulstaert PF, Vos A, Verhoef J, Wittebol P (1988) Prevention of colonization and infection in critically ill patients: a prospective randomized study. Crit Care Med 16:1087–1093
Korinek AM, Laisne MJ, Nicolas MH, Raskine L, Deroin V, Sanson-Lepors MJ (1993) Selective decontamination of the digestive tract in neurosurgical intensive care unit patients: a double-blind, randomized, placebo-controlled study. Crit Care Med 21:14661473
Krueger WA, Lenhart F-P, Neeser G et al (2002) Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical patients. A prospective, stratified, randomized, double-blind, placebo-controlled clinical trial. Am J Respir Crit Care Med 166:1029–1037
Laggner AN, Tryba M, Georgopulos A et al (1994) Oropharyngeal decontamination with gentamicin for long-stay ventilated patients on stress ulcer prophylaxis with sucralfate? Wien Klin Wochenschr 106:15–19
Lingnau W, Berger J, Javorsky F, Lejeune P, Mutz N, Benzer H (1997) Selective intestinal decontamination in multiple trauma patients: prospective, controlled trial. J Trauma 42:687–694
Luiten EJT, Hop WCJ, Lange JF, Bruining HA (1995) Controlled clinical trial of selective decontamination for the treatment of severe acute pancreatitis.Ann Surg 222:57–65
Martinez-Pellus AE, Merino P, Bru M et al (1993) Can selective digestive decontamination avoid the endotoxemia and cytokine activation promoted by cardiopulmonary bypass? Crit Care Med 21:1684–1691
Martinez-Pellus AE, Merino P, Bru M, Canovas J, Seller G, Sapina J, Fuentes T, Moro J (1997) Endogenous endotoxemia of intestinal origin during cardiopulmonary bypass. Role of type of flow and protective effect of selective digestive decontamination. Intensive Care Med 23:1251–1257
Palomar M, Alvarez-Lerma F, Jorda R, Bermejo B, and the Catalan study group of nosocomial pneumonia prevention (1997) Prevention of nosocomial infection in mechanically ventilated patients: selective digestive decontamination versus sucralfate. Clin Intensive Care 8:228–235
Pneumatikos I, Koulouras V, Nathanail C, Goe D, Nakos G (2002) Selective decontamination of subglottic area in mechanically ventilated patients with multiple trauma. Intensive Care Med 28:432–437
Pugin J, Auckenthaler R, Lew DP, Suter PM (1991) Oropharyngeal decontamination decreases incidence of ventilator-associated pneumonia. A randomized, placebo-controlled, double-blind clinical trial. JAMA 265:2704–2710
Quinio B, Albanese J, Bues-Charbit M, Viavind X, Martin C (1996) Selective decontamination of the digestive tract in multiple trauma patients. A prospective doubleblind, randomized, placebo-controlled study. Chest 109:765–772
Rayes N, Seehofer D, Hansen S, Boucsein K, Muller AR, Serke S et al (2002) Early enteral supply of Lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients. Transplantation 74:123–128
Rocha LA, Martin MJ, Pita S, Paz J, Seco C, Margusino L, Villanueva R, Duran MT (1993) Prevention of nosocomial infection in critically ill patients by selective decontamination of the digestive tract. A randomized, double-blind, placebo controlled study. Intensive Care Med 18:398–404
Rodriguez-Roldan JM, Altuna-Cuesta A, Lopez A, Carrillo A, Garcia J, Leon J Martinez-Pellus AJ (1990) Prevention of nosocomial lung infection in ventilated patients: use of an antimicrobial pharyngeal nonabsorbable paste. Crit Care Med 18:1239–1242
Rolando N, Gimson A, Wade J, Philpott-Howard J, Casewell M, Williams R (1993) Prospective controlled trial of selective parenteral and enteral antimicrobial regimen in fulminant liver failure. Hepatology 17:196–201
Rolando N, Wade JJ, Stangou A, Gimson AES, Wendon J, Philpott-Howard J, Casewell MW, Williams R (1996) Prospective study comparing the efficacy of prophylactic parenteral antimicrobials with or without enteral decontamination, in patients with acute liver failure. Liver Transplant Surg 2:8–13
Ruza F, Alvarado F, Herruzo R, Delgado MA, Garcia S, Dorao P, Godel F (1998) Prevention of nosocomial infection in a pediatric intensive care unit (PICU) through the use of selective digestive decontamination. Eur J Epidemiol 14:719–727
Sanchez Garcia M, Cambronero Galache JA, Lopez Diaz J et al (1998) Effectiveness and cost of selective decontamination of the digestive tract in critically ill intubated patients. A randomized, double-blind, placebo-controlled, multicenter trial. Am J Respir Crit Care Med 158:908–916
Schardey HM, Joosten U, Finke U et al (1997) The prevention of anastomotic leakage after total gastrectomy with local decontamination. A prospective, randomized, double-blind, placebo-controlled, multicenter trial. Ann Surg 225:172–180
Smith SD, Jackson RJ, Hannakan CJ, Wadowsky RM, Tzakis AG, Rowe MI (1993) Selective decontamination in pediatric liver transplants. A randomized prospective study. Transplantation 55:1306–1309
Stoutenbeek CP, van Saene HKF, Zandstra DF (1996) Prevention of multiple organ failure by selective decontamination of the digestive tract in multiple trauma patients. In: Faist E, Baue AE, Schildberg FW (eds) The immune consequences of trauma, shock and sepsis — mechanisms and therapeutic approach. Pabst Science Publishers, Lengerich, pp 1055–1066
Stoutenbeek CP, van Saene HKF, Little RA, Whitehead A, for the working group on selective decontamination of the digestive tract (2005) The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients. Intensive Care Med (in press)
Tetteroo GWM, Wagenvoort JHT, Castelein A, Tilanus HW, Ince C, Bruining HA (1990) Selective decontamination to reduce gram-negative colonisation and infections after oesophageal resection. Lancet 335:704–707
Ulrich C, Harinck-de Weerd JE, Bakker NC, Jacz K, Doornbos L, de Ridder VA (1989) Selective decontamination of the digestive tract with norfloxacin in the prevention of ICU-acquired infections: a prospective randomized study. Intensive Care Med 15:424–431
Unertl K, Ruckdeschel G, Selbmann HK, Jensen U, Forst H, Lenhart FP, Peter K (1987) Prevention of colonization and respiratory infections in long-term ventilated patients by local antimicrobial prophylaxis. Intensive Care Med 13:106–113
Verwaest C, Verhaegen J, Ferdinande P, Schetz M, van den Berghe G, Verbist L, Lauwers P (1997) Randomized, controlled trial of selective digestive decontamination in 600 mechanically ventilated patients in a multidisciplinary intensive care unit. Crit Care Med 25:63–71
Wiener J, Itokazu G, Nathan C, Kabins SA, Weinstein RA (1995) A randomized, doubleblind, placebo-controlled trial of selective digestive decontamination in a medicalsurgical intensive care unit. Clin Infect Dis 20:861–867
Winter R, Humphreys H, Pick A, MacGowan AP, Willatts SM, Speller DCE (1992) A controlled trial of selective decontamination of the digestive tract in intensive care and its effect on nosocomial infection. J Antimicrob Chemother 30:73–87
Zobel G, Kutting M, Grubbauer H-M, Semmelrock H-J, Thiel W (1991) Reduction of colonization and infection rate during pediatric intensive care by selective decontamination of the digestive tract. Crit Care Med 19:1242–1246
Zwaveling JH, Maring JK, Klompmaker IJ et al (2002) Selective decontamination of the digestive tract to prevent postoperative infection: a randomized placebo-controlled trial in liver transplant patients. Crit Care Med 30:1204–1209
Selective Decontamination of the Digestive Tract Trialists’ Collaborative Group (1993) Meta-analysis of randomised controlled trials of selective decontamination of the digestive tract. BMJ 307:525–532
Kollef M (1994) The role of selective digestive tract decontamination on mortality and respiratory tract infections.A meta-analysis. Chest 105:1101–1108
Heyland DK, Cook DJ, Jaeschke R, Griffith L, Lee HN, Guyatt GH (1994) Selective decontamination of the digestive tract: an overview. Chest 105:1221–1229
D’Amico R, Pifferi S, Leonetti C, Torri V, Tinazzi A, Liberati A (1998) Effectiveness of antibiotic prophylaxis in critically ill adult patients: systematic review of randomized controlled trials. BMJ 316:1275–1285
Nathens AB, Marshall JC (1999) Selective decontamination of the digestive tract in surgical patients. A systematic review of the evidence. Arch Surg 134:170–176
Redman R, Ludington E, Crocker M, Wittes J, Bellm L, Carlet J and the VAP Advisory Group (2001) Analysis of respiratory and non-respiratory infections in published trials of selective digestive decontamination. Intensive Care Med 27[Suppl]:S285
Silvestri I, Milanese M, Gregori D, van Saene HKF (2003) Impact of SDD on fungal carriage and infection: a meta-analysis. Intensive Care Med 29[Suppl 1]:S128
Liberati A, D’Amico R, Pifferi S, Torri V, Brazzi L (2004) Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. Cochrane Review. In: The Cochrane Library, Issue 1. John Wiley and Sons, Chichester, UK
Safdar N, Said A, Lucey MR (2004) The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation: a systematic review and meta-analysis. Liver Transpl 10:817–827
Sanchez M, Mir N, Canton R et al (1997) The effect of topical vancomycin on acquisition, carriage and infection with methicillin-resistant Staphylococcus aureus in critically ill patients. A double-blind, randomized, placebo controlled study. 37th ICAAC, Toronto, Canada. Abstract J-119:310
Silvestri L, van Saene HKF, Milanese M et al (2004) Prevention of MRSA pneumonia by oral vancomycin decontamination: a randomised trial. Eur Respir J 23:921–926
Baines P, van Saene H (2004) Selective decontamination of the digestive tract and prevention of ventilator-associated pneumonia. Ann Intern Med 141:577–578
Hammond MJ, Potgieter PD (1995) Long-term effects of selective decontamination on antimicrobial resistance. Crit Care Med 23:637–645
Stoutenbeek CP, van Saene HKF, Zandstra DF (1987) The effect of oral non-absorbable antibiotics on the emergence of resistant bacteria in patients in an intensive care unit. J Antimicrob Chemother 19:513–520
Lingnau W, Berger J, Javorsky F et al (1998) Changing bacterial ecology during a five-year period of selective intestinal decontamination. J Hosp Infect 39:195–206
Sarginson RE, Taylor N, Reilly N et al (2004) Infection in prolonged pediatric critical illness: A prospective four-year study based on knowledge of the carrier state. Crit Care Med 32:839–847
Leone M, Albanese J, Antonini F et al (2003) Long-term (6-year) effect of selective digestive decontamination on antimicrobial resistance in intensive care, multipletrauma patients. Crit Care Med 31:2090–2095
Tetteroo GW, Wagenvoort JH, Bruining HA (1994) Bacteriology of selective decontamination: efficacy and rebound colonization. J Antimicrob Chemother 34:139–148
Silvestri L, Milanese M, Oblach L, Fontana F, Gregori D, Guerra R, van Saene HKF (2002) Enteral vancomycin to control methicillin-resistant Staphylococcus aureus outbreak in mechanically ventilated patients. Am J Infect Control 30:391–399
de la Cal MA, Cerda E, van Saene HKF, Garcia-Hierro P, Negro E, Parra ML, Arias S, Ballestreros D (2003) Effectiveness and safety of enteral vancomycin to control endemicity of methicillin-resistant Staphylococcus aureus in a medical/surgical intensive care unit. J Hosp Infect 56:175–183
Chaix C, Durand-Zaleski I, Alberti C, Brun-Buisson C (1999) Control of endemic methicillin-resistant Staphylococcus aureus. A cost-benefit analysis in an intensive care unit. JAMA 282:1745–1751
Veenstra DL, Saint S, Sullivan SD (1999) Cost-effectiveness of antiseptic-impregnated central venous catheters for the prevention of catheter-related bloodstream infection. JAMA 11:282:554–560
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2005 Springer-Verlag Italia
About this chapter
Cite this chapter
Silvestri, L., Kerr, S., Gullo, A. (2005). Prevention of Infection Using Selective Decontamination of the Digestive Tract. In: van Saene, H.K.F., De La Cal, M.A., Silvestri, L. (eds) Infection Control in the Intensive Care Unit. Topics in Anaesthesia and Critical Care. Springer, Milano . https://doi.org/10.1007/88-470-0361-X_14
Download citation
DOI: https://doi.org/10.1007/88-470-0361-X_14
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0185-5
Online ISBN: 978-88-470-0361-3
eBook Packages: MedicineMedicine (R0)