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Adaptive Immunity Against Staphylococcus aureus

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Book cover Staphylococcus aureus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 409))

Abstract

A complex interplay between host and bacterial factors allows Staphylococcus aureus to occupy its niche as a human commensal and a major human pathogen. The role of neutrophils as a critical component of the innate immune response against S. aureus, particularly for control of systemic infection, has been established in both animal models and in humans with acquired and congenital neutrophil dysfunction. The role of the adaptive immune system is less clear. Although deficiencies in adaptive immunity do not result in the marked susceptibility to S. aureus infection that neutrophil dysfunction imparts, emerging evidence suggests both T cell- and B cell-mediated adaptive immunity can influence host susceptibility and control of S. aureus. The contribution of adaptive immunity depends on the context and site of infection and can be either beneficial or detrimental to the host. Furthermore, S. aureus has evolved mechanisms to manipulate adaptive immune responses to its advantage. In this chapter, we will review the evidence for the role of adaptive immunity during S. aureus infections. Further elucidation of this role will be important to understand how it influences susceptibility to infection and to appropriately design vaccines that elicit adaptive immune responses to protect against subsequent infections.

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Acknowledgements

This work was supported by the Intramural Research Program of the NIH, NIAID.

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  1. Bacterial Pathogenesis Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD, 20892, USA

    Hatice Karauzum & Sandip K. Datta

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  1. Hatice Karauzum
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Correspondence to Sandip K. Datta .

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  1. GSK Vaccines, Siena, Italy

    Fabio Bagnoli

  2. GSK Vaccines, Siena, Italy

    Rino Rappuoli

  3. Center for Integrative Biology (CIBIO), University of Trento, Trento, Italy

    Guido Grandi

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Karauzum, H., Datta, S.K. (2016). Adaptive Immunity Against Staphylococcus aureus . In: Bagnoli, F., Rappuoli, R., Grandi, G. (eds) Staphylococcus aureus. Current Topics in Microbiology and Immunology, vol 409. Springer, Cham. https://doi.org/10.1007/82_2016_1

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