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Role of Calcium Signaling in B Cell Activation and Biology

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Book cover B Cell Receptor Signaling

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 393))

Abstract

Increase in intracellular levels of calcium ions (Ca2+) is one of the key triggering signals for the development of B cell response to the antigen. The diverse Ca2+ signals finely controlled by multiple factors participate in the regulation of gene expression, B cell development, and effector functions. B cell receptor (BCR)-initiated Ca2+ mobilization is sourced from two pathways: one is the release of Ca2+ from the intracellular stores, endoplasmic reticulum (ER), and other is the prolonged influx of extracellular Ca2+ induced by depleting the stores via store-operated calcium entry (SOCE) and calcium release-activated calcium (CRAC) channels. The identification of stromal interaction molecule 1(STIM1), the ER Ca2+ sensor, and Orai1, a key subunit of the CRAC channel pore, has now provided the tools to understand the mode of Ca2+ influx regulation and physiological relevance. Herein, we discuss our current understanding of the molecular mechanisms underlying BCR-triggered Ca2+ signaling as well as its contribution to the B cell biological processes and diseases.

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Abbreviations

EAE:

Experimental autoimmune encephalomyelitis

CRAC:

Ca2+ release-activated Ca2+

DAG:

Diacylglycerol

ER:

Endoplasmic reticulum

IP3:

Inositol-1,4,5,-triphosphate

ITIM:

Immunoreceptor tyrosine-based inhibition motifs

Phospholipase C-γ2:

PLC-γ2

PI3K:

Phosphoinositide 3-kinase

PIP5K:

Phosphatidylinositol-4-phosphate 5-kinases

PM:

Plasma membrane

PtdIns(3,4)P2:

Phosphatidylinositol-3,4-bisphosphate

PtdIns(4,5)P2:

Phosphatidylinositol-4,5-bisphosphate

PtdIns(3,4,5)P3:

Phosphatidylinositol-3,4,5-trisphosphate

SHP1:

SH2-domain-containing protein tyrosine phosphatase 1

SHIP:

SH2-domain-containing inositol polyphosphate 5′ phosphatase

SOCE:

Store-operated Ca2+ entry

STIM1:

Stromal interaction molecule 1

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Authors and Affiliations

  1. Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center (IFReC), Osaka University, Suita, Osaka, 565-0871, Japan

    Yoshihiro Baba & Tomohiro Kurosaki

  2. Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences (IMS), Kanagawa, Yokohama, 230-0045, Japan

    Yoshihiro Baba & Tomohiro Kurosaki

Authors
  1. Yoshihiro Baba
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  2. Tomohiro Kurosaki
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Correspondence to Yoshihiro Baba .

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Editors and Affiliations

  1. WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan

    Tomohiro Kurosaki

  2. Cellular and Molecular Immunology, Georg August University Goettingen, Göttingen, Germany

    Jürgen Wienands

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Baba, Y., Kurosaki, T. (2015). Role of Calcium Signaling in B Cell Activation and Biology. In: Kurosaki, T., Wienands, J. (eds) B Cell Receptor Signaling. Current Topics in Microbiology and Immunology, vol 393. Springer, Cham. https://doi.org/10.1007/82_2015_477

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