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Cancer Vaccines pp 79–97Cite as

Targeted Immunotherapy Designed to Treat MUC1-Expressing Solid Tumour

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 405))

Abstract

Several approaches to antigen-specific immunotherapy of cancer antigen-specific immunotherapy of cancer have been tested clinically. In this chapter, we will describe studies done with the antigen MUC1. Tested MUC1 therapeutic vaccines include the following: monoclonal antibodies (MAbs) specific for MUC1; synthetic and recombinant polypeptides from the protein sequence of MUC1; dendritic cells carrying MUC1; RNA and DNA vaccinations; and recombinant viruses carrying the MUC1 DNA sequence. Chemotherapy of cancer aims to be toxic to the cancer cells with manageable side effects to the patient. In contrast, antigen-specific immunotherapy of cancer aims to treat the patient, such that the patient is then able to control and eventually eliminate their cancer cells. It is therefore important to know the immune status of each cancer patient prior to therapy.

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Authors and Affiliations

  1. Department of Medical Affairs, Transgene SA, 400 Blvd Gonthier d’Andernach, Parc d’Innovation CS80166, 67405, Illkirch-Graffenstaden Cedex, France

    Gisele Lacoste & Jean-Marc Limacher

  2. Bruce Acres Consulting, Strasbourg, France

    Bruce Acres

Authors
  1. Bruce Acres
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  2. Gisele Lacoste
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  3. Jean-Marc Limacher
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Correspondence to Gisele Lacoste .

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Editors and Affiliations

  1. Faculty of Medicine, Cancer Sciences Unit, University of Southampton, Southhampton, United Kingdom

    Natalia Savelyeva

  2. Faculty of Medicine, Cancer Sciences Unit, University of Southampton , Southampton, United Kingdom

    Christian Ottensmeier

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Acres, B., Lacoste, G., Limacher, JM. (2015). Targeted Immunotherapy Designed to Treat MUC1-Expressing Solid Tumour. In: Savelyeva, N., Ottensmeier, C. (eds) Cancer Vaccines. Current Topics in Microbiology and Immunology, vol 405. Springer, Cham. https://doi.org/10.1007/82_2015_429

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