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Genetic Diversity in Mycobacterium tuberculosis

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Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 374))

Abstract

Recent years have witnessed an increased appreciation of the extent and relevance of strain-to-strain variation in Mycobacterium tuberculosis. This paradigm shift can largely be attributed to an improved understanding of the global population structure of this organism, and to the realisation that the various members of the M. tuberculosis complex (MTBC) harbour more genetic diversity than previously realised. Moreover, many studies using experimental models of infection have demonstrated that MTBC diversity translates into significant differences in immunogenecity and virulence . However, linking these experimental phenotypes to relevant clinical phenotypes has been difficult, and to date, largely unsuccessful. Nevertheless, emerging high-throughput technologies, in particular next-generation sequencing , offer new opportunities, and have already lead to important new insights. Given the complexity of the host-pathogen interaction in tuberculosis, systems approaches will be key to define the role of MTBC diversity in the fight against one of humankind’s most important pathogens.

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Acknowledgments

I thank Douglas Young, Iñaki Comas and all the members of my group for the stimulating discussions and comments on the manuscript. Work in my laboratory is supported by the Swiss National Science Foundation (grant number PP0033-119205), the National Institutes of Health (AI090928 and HHSN266200700022C) the Leverhulme-Royal Society Africa Award (AA080019) and the European Research Council (309540).

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  1. Swiss Tropical and Public Health Institute (Swiss TPH), University of Basel, Basel, Switzerland

    Sebastien Gagneux

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Correspondence to Sebastien Gagneux .

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  1. Biozentrum, University of Basel, Basel, Switzerland

    Jean Pieters

  2. Laboratory of Microbiology and Microsystems, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland

    John D. McKinney

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Gagneux, S. (2013). Genetic Diversity in Mycobacterium tuberculosis . In: Pieters, J., McKinney, J. (eds) Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism. Current Topics in Microbiology and Immunology, vol 374. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2013_329

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