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Plant Viral Epitope Display Systems for Vaccine Development

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Plant Viral Vectors

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 375))

Abstract

The ‘easiest’ vaccines, base on production of neutralizing antibodies, have been made. With the emergence of chronic diseases, vaccine developers have understood the importance to trigger an efficient cellular mediated immune response (CTL response) to respond to this medical need. Several options are currently in development and the utilization of plant virus as vaccine platform for the trigger of a CTL response is considered as an interesting avenue. The highly ordered structures of plant viruses are good triggers of the innate immune system, which in turn, is used to initiate an immune response to a vaccine target. It is likely that plant viruses will play an important role in the development of the vaccine of the futures even if there is still several challenges to face.

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Abbreviations

APCs:

Antigen presentation cells

CD8+:

Cytotoxic T cells with CD8 surface protein are called CD8+ T cells

CP:

Coat protein

CPMV:

Cowpea mosaic virus

DCs:

Dendritic cells

CTL:

Cytotoxic T lymphocytes

FMDV:

Foot-and-mouth disease

Gp100:

Melanosomal matrix protein whose expression is closely correlated with cellular melanin content

GFP:

Gellyfish fluorescent protein

HBV:

Hepatitis B virus

HCV:

Hepatitis C virus

HIV-1:

Human immunodeficiency virus-1

HLA:

Human leucocyte antigene

HPV:

Human papilloma virus

IFN-γ:

Interferon gamma

LCMV:

Lymphocytic choriomeningitis virus

MaMV:

Malva mosaic virus

MHC class 1:

One of two primary classes of major histocompatibility complex (MHC) molecules I

PAMPs:

Pathogen associated molecular patterns

PapMV:

Papaya mosaic virus

PPV:

Procine parvorvirus

PVX:

Potato virus X

TAP:

Transporter associated with antigen processing

TMV:

Tobacco mosaic virus

VLPs:

Virus like particles

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Authors and Affiliations

  1. Infectious Diseases Research Centre, Pavilion CHUL, Laval University, 2705 Boulevard Laurier, Quebec City, PQ, G1V 4G2, Canada

    Denis Leclerc

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  1. Denis Leclerc
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Correspondence to Denis Leclerc .

Editor information

Editors and Affiliations

  1. James Graham Brown Cancer Center, University of Louisville, Owensboro, Kentucky, USA

    Kenneth Palmer

  2. Nomad Bioscience GmbH, Icon Genetics GmbH, Halle, Germany

    Yuri Gleba

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Leclerc, D. (2011). Plant Viral Epitope Display Systems for Vaccine Development. In: Palmer, K., Gleba, Y. (eds) Plant Viral Vectors. Current Topics in Microbiology and Immunology, vol 375. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2011_183

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