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Ricin and Shiga Toxins pp 105–136Cite as

Shiga Toxin Pathogenesis: Kidney Complications and Renal Failure

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 357))

Abstract

The kidneys are the major organs affected in diarrhea-associated hemolytic uremic syndrome (D+HUS). The pathophysiology of renal disease in D+HUS is largely the result of the interaction between bacterial virulence factors such as Shiga toxin and lipopolysaccharide and host cells in the kidney and in the blood circulation. This chapter describes in detail the current knowledge of how these bacterial toxins may lead to kidney disease and renal failure. The toxin receptors expressed by specific blood and resident renal cell types are also discussed as are the actions of the toxins on these cells.

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Acknowledgments

This publication was made possible by Grant Numbers AI024431, AI054782, and AI075778 to TGO from the National Institute of Allergy and Infectious Diseases, National Institutes of Health. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Diana Karpman is supported by grants from The Swedish Research Council (K2010-65X-14008), Torsten and Ragnar Söderberg Foundation, The Fund for Renal Research, Crown Princess Lovisa’s Society for Child Care, The Konung Gustaf V:s 80-årsfond, Fanny Ekdahl’s Foundation and is the recipient of a clinical-experimental research fellowship from the Royal Swedish Academy of Sciences.

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  1. Department of Microbiology and Immunology, University of Maryland, School of Medicine, 685 West Baltimore Street, HSF-I Suite 380, Baltimore, MD, 21201, USA

    Tom G. Obrig

  2. Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden

    Diana Karpman

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  1. Tom G. Obrig
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Correspondence to Tom G. Obrig .

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  1. , Division of Infectious Diseases, NYDOH, Wadsworth Center, New Scotland Ave 120, Albany, 12208, New York, USA

    Nicholas Mantis

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Obrig, T.G., Karpman, D. (2011). Shiga Toxin Pathogenesis: Kidney Complications and Renal Failure. In: Mantis, N. (eds) Ricin and Shiga Toxins. Current Topics in Microbiology and Immunology, vol 357. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2011_172

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