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Cell Entry by Non-Enveloped Viruses pp 195–224Cite as

Adenovirus

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 343))

Abstract

Of the 53 different human adenovirus (HAdV) serotypes belonging to species A-G, a significant number are associated with acute respiratory, gastrointestinal and ocular infections. Replication-defective HAdV-5-based vectors also continue to play a significant role in gene transfer trials and in vaccine delivery efforts in the clinic. Although significant progress has been made from studies of AdV biology, we still have an incomplete understanding of AdV’s structure as well as its multifactorial interactions with the host. Continuing efforts to improve knowledge in these areas, as discussed in this chapter, will be crucial for revealing the mechanisms of AdV pathogenesis and for allowing optimal use of AdV vectors for biomedical applications.

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Acknowledgement

This work is manuscript No. 19961 at The Scripps Research Institute.

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Authors and Affiliations

  1. Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 N. Torrey Pines Road, IMM-19, La Jolla, CA, 92037, USA

    Jason G. Smith & Glen R. Nemerow

  2. Department of Microbiology and Immunology, Loyola University Medical Center, Maywood, IL, 60153, USA

    Christopher M. Wiethoff

  3. Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

    Phoebe L. Stewart

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  1. Jason G. Smith
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  2. Christopher M. Wiethoff
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  3. Phoebe L. Stewart
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  4. Glen R. Nemerow
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Correspondence to Glen R. Nemerow .

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  1. Dept. Molecular Biology, Scripps Research Institute, N. Torrey Pines Rd. 10550, La Jolla, 92037, California, USA

    John E. Johnson

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Smith, J.G., Wiethoff, C.M., Stewart, P.L., Nemerow, G.R. (2010). Adenovirus. In: Johnson, J. (eds) Cell Entry by Non-Enveloped Viruses. Current Topics in Microbiology and Immunology, vol 343. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_16

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