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The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research

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Translational Neuropsychopharmacology

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 28))

Abstract

Over the past two decades, major advances have been made in the basic neuroscience of alcohol addiction. However, few of these have been translated into clinically useful treatments, which remain limited. In the past decade, psychiatric drug development in general has been stalled, with many preclinically validated mechanisms failing in clinical development. Despite the existence of appealing preclinical models in the area of addictive disorders, drug development for these conditions has been impacted by the exodus of major pharma from psychiatric neuroscience. Here, we discuss translational biomarker strategies that may help turn this tide. Following an approach patterned on an endophenotype approach to complex behavioral traits, we hypothesize that relatively simple biological measures should be sought that can be obtained both in experimental animals and in humans, and that may be responsive to alcoholism medications. These biomarkers have to be tailored to the specific mechanism targeted by candidate medications and may in fact also help identify biologically more homogeneous subpopulations of patients. We introduce as examples alcohol-induced dopamine (DA) release, measures of central glutamate levels, and network connectivity, and discuss our experience to date with these biomarker strategies.

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Authors and Affiliations

  1. Center for Social and Affective Neuroscience, Department of Clinical and Experimental Medicine, Linköping University, SE-58183, Linköping, Sweden

    Markus Heilig

  2. Institute of Psychopharmacology, Central Institute of Mental Health, Faculty of Medicine Mannheim, University of Heidelberg, Heidelberg, Germany

    Wolfgang H. Sommer & Rainer Spanagel

Authors
  1. Markus Heilig
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  2. Wolfgang H. Sommer
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  3. Rainer Spanagel
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Correspondence to Markus Heilig .

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Editors and Affiliations

  1. University of Cambridge, Cambridge, UK

    Trevor W. Robbins

  2. University of Cambridge, Cambridge, UK

    Barbara J. Sahakian

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© 2015 Springer International Publishing Switzerland

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Heilig, M., Sommer, W.H., Spanagel, R. (2015). The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research. In: Robbins, T.W., Sahakian, B.J. (eds) Translational Neuropsychopharmacology. Current Topics in Behavioral Neurosciences, vol 28. Springer, Cham. https://doi.org/10.1007/7854_2015_5006

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