Skip to main content
SpringerLink
Log in
Book cover

Sleep, Neuronal Plasticity and Brain Function pp 483–502Cite as

Sleep Deprivation Therapy for Depression

  • Chapter
  • First Online:

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 25))

Abstract

Sleep deprivation (SD) is the most widely documented rapid-onset antidepressant therapy, targeting the broadly defined depressive syndrome. Although SD responses are transient, its effects can be sustained by concomitant medications (e.g., selective serotonin reuptake inhibitors and lithium) and circadian-related interventions (e.g., bright light and sleep phase advance). Thus, considering its safety, this technique can now be considered among the first-line antidepressant treatment strategies for patients affected by mood disorders. SD is a complex intervention and it should be considered multi-target in nature. Thus, the mechanisms explaining its antidepressant effect can be looked for on many levels, involving not only monoaminergic mechanisms but also sleep homeostatic and circadian mechanisms, glutamatergic mechanisms and synaptic plasticity.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Adli M, Hollinde DL, Stamm T et al (2007) Response to lithium augmentation in depression is associated with the glycogen synthase kinase 3-beta −50T/C single nucleotide polymorphism. Biol Psychiatry 62:1295–1302

    CAS  PubMed  Google Scholar 

  • Adrien J (2002) Neurobiological bases for the relation between sleep and depression. Sleep Med Rev 6:341–351

    PubMed  Google Scholar 

  • Amin MM, Khalid R, Khan P (1980) Relationship between sleep deprivation and urinary MHPG levels. Int Pharmacopsychiatry 15:81–85

    CAS  PubMed  Google Scholar 

  • Asikainen M, Toppila J, Alanko L, Ward DJ, Stenberg D, Porkka-Heiskanen T (1997) Sleep deprivation increases brain serotonin turnover in the rat. NeuroReport 8:1577–1582

    CAS  PubMed  Google Scholar 

  • Barbini B, Colombo C, Benedetti F, Campori E, Bellodi L, Smeraldi E (1998) The unipolar-bipolar dichotomy and the response to sleep deprivation. Psychiatry Res 79:43–50

    CAS  PubMed  Google Scholar 

  • Basheer R, Magner M, McCarley RW, Shiromani PJ (1998) REM sleep deprivation increases the levels of tyrosine hydroxylase and norepinephrine transporter mRNA in the locus coeruleus. Brain Res Mol Brain Res 57:235–240

    CAS  PubMed  Google Scholar 

  • Baumgartner A, Riemann D, Berger M (1990) Neuroendocrinological investigations during sleep deprivation in depression. II. Longitudinal measurement of thyrotropin, TH, cortisol, prolactin, GH, and LH during sleep and sleep deprivation. Biol Psychiatry 28:569–587

    PubMed  Google Scholar 

  • Benedetti F, Barbini B, Campori E, Colombo C, Smeraldi E (1996) Dopamine agonist amineptine prevents the antidepressant effect of sleep deprivation. Psychiatry Res 65:179–184

    CAS  PubMed  Google Scholar 

  • Benedetti F, Barbini B, Lucca A, Campori E, Colombo C, Smeraldi E (1997) Sleep deprivation hastens the antidepressant action of fluoxetine. Eur Arch Psychiatry Clin Neurosci 247:100–103

    CAS  PubMed  Google Scholar 

  • Benedetti F, Colombo C, Barbini B, Campori E, Smeraldi E (1999a) Ongoing lithium treatment prevents relapse after total sleep deprivation. J Clin Psychopharmacol 19:240–245

    CAS  PubMed  Google Scholar 

  • Benedetti F, Serretti A, Colombo C et al (1999b) Influence of a functional polymorphism within the promoter of the serotonin transporter gene on the effects of total sleep deprivation in bipolar depression. Am J Psychiatry 156:1450–1452

    CAS  PubMed  Google Scholar 

  • Benedetti F, Zanardi R, Colombo C, Smeraldi E (1999c) Worsening of delusional depression after sleep deprivation: case reports. J Psychiatr Res 33:69–72

    CAS  PubMed  Google Scholar 

  • Benedetti F, Campori E, Barbini B, Fulgosi MC, Colombo C (2001) Dopaminergic augmentation of sleep deprivation effects in bipolar depression. Psychiatry Res 104:239–246

    CAS  PubMed  Google Scholar 

  • Benedetti F, Lucca A, Brambilla F, Colombo C, Smeraldi E (2002) Interleukine-6 serum levels correlate with response to antidepressant sleep deprivation and sleep phase advance. Prog Neuropsychopharmacol Biol Psychiatry 26:1167–1170

    CAS  PubMed  Google Scholar 

  • Benedetti F, Colombo C, Serretti A et al (2003a) Antidepressant effects of light therapy combined with sleep deprivation are influenced by a functional polymorphism within the promoter of the serotonin transporter gene. Biol Psychiatry 54:687–692

    CAS  PubMed  Google Scholar 

  • Benedetti F, Serretti A, Colombo C, Lilli R, Lorenzi C, Smeraldi E (2003b) Dopamine receptor D2 and D3 gene variants are not associated with the antidepressant effect of total sleep deprivation in bipolar depression. Psychiatry Res 118:241–247

    CAS  PubMed  Google Scholar 

  • Benedetti F, Bernasconi A, Lorenzi C et al (2004a) A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder. Neurosci Lett 355:37–40

    CAS  PubMed  Google Scholar 

  • Benedetti F, Serretti A, Colombo C, Lorenzi C, Tubazio V, Smeraldi E (2004b) A glycogen synthase kinase 3-beta promoter gene single nucleotide polymorphism is associated with age at onset and response to total sleep deprivation in bipolar depression. Neurosci Lett 368:123–126

    CAS  PubMed  Google Scholar 

  • Benedetti F, Barbini B, Fulgosi MC et al (2005a) Combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: acute response and long-term remission rates. J Clin Psychiatry 66:1535–1540

    CAS  PubMed  Google Scholar 

  • Benedetti F, Serretti A, Pontiggia A et al (2005b) Long-term response to lithium salts in bipolar illness is influenced by the glycogen synthase kinase 3-beta −50 T/C SNP. Neurosci Lett 376:51–55

    CAS  PubMed  Google Scholar 

  • Benedetti F, Barbini B, Colombo C, Smeraldi E (2007a) Chronotherapeutics in a psychiatric ward. Sleep Med Rev 11:509–522

    PubMed  Google Scholar 

  • Benedetti F, Bernasconi A, Blasi V et al (2007b) Neural and genetic correlates of antidepressant response to sleep deprivation: a fMRI study of moral valence decision in bipolar depression. Arch Gen Psychiatry 64:179–187

    PubMed  Google Scholar 

  • Benedetti F, Dallaspezia S, Fulgosi MC, Barbini B, Colombo C, Smeraldi E (2007c) Phase advance is an actimetric correlate of antidepressant response to sleep deprivation and light therapy in bipolar depression. Chronobiol Int 24:921–937

    CAS  PubMed  Google Scholar 

  • Benedetti F, Barbini B, Bernasconi A et al (2008a) Lithium overcomes the influence of 5-HTTLPR gene polymorphism on antidepressant response to sleep deprivation. J Clin Psychopharmacol 28:249–251

    PubMed  Google Scholar 

  • Benedetti F, Barbini B, Bernasconi A et al (2008b) Serotonin 5-HT2A receptor gene variants influence antidepressant response to repeated total sleep deprivation in bipolar depression. Prog Neuropsychopharmacol Biol Psychiatry 32:1863–1866

    CAS  PubMed  Google Scholar 

  • Benedetti F, Calabrese G, Bernasconi A et al (2009) Spectroscopic correlates of antidepressant response to sleep deprivation and light therapy: a 3.0 Tesla study of bipolar depression. Psychiatry Res 173:238–242

    CAS  PubMed  Google Scholar 

  • Benedetti F, Barbini B, Bernasconi A et al (2010) Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism. J Affect Disord 121:68–72

    CAS  PubMed  Google Scholar 

  • Benedetti F, Dallaspezia S, Lorenzi C et al (2011) Gene–gene interaction of glycogen synthase kinase 3-beta and serotonin transporter on human antidepressant response to sleep deprivation. J Affect Disord 136:514–519

    PubMed  Google Scholar 

  • Berger M, Vollmann J, Hohagen F et al (1997) Sleep deprivation combined with consecutive sleep phase advance as a fast-acting therapy in depression: an open pilot trial in medicated and unmedicated patients. Am J Psychiatry 154:870–872

    CAS  PubMed  Google Scholar 

  • Bertolucci PH, Andrade LA, Lima JG, Carlini EA (1987) Total sleep deprivation and Parkinson disease. Arq Neuropsiquiatr 45:224–230

    CAS  PubMed  Google Scholar 

  • Borbely AA, Wirz-Justice A (1982) Sleep, sleep deprivation and depression. A hypothesis derived from a model of sleep regulation. Hum Neurobiol 1:205–210

    CAS  PubMed  Google Scholar 

  • Bunney BG, Bunney WE (2013) Mechanisms of rapid antidepressant effects of sleep deprivation therapy: clock genes and circadian rhythms. Biol Psychiatry 73:1164–1171

    CAS  PubMed  Google Scholar 

  • Bushey D, Tononi G, Cirelli C (2011) Sleep and synaptic homeostasis: structural evidence in Drosophila. Science 332:1576–1581

    PubMed Central  CAS  PubMed  Google Scholar 

  • Canali P, Sferrazza Papa G, Casali AG et al (2014) Changes of cortical excitability as markers of antidepressant response in bipolar depression: preliminary data by combining TMS and EEG. Bipolar Disord

    Google Scholar 

  • Cirelli C, Tononi G (2000) Gene expression in the brain across the sleep-waking cycle. Brain Res 885:303–321

    CAS  PubMed  Google Scholar 

  • Clark CP, Brown GG, Archibald SL et al (2006) Does amygdalar perfusion correlate with antidepressant response to partial sleep deprivation in major depression? Psychiatry Res 146:43–51

    PubMed Central  PubMed  Google Scholar 

  • Colombo C, Benedetti F, Barbini B, Campori E, Smeraldi E (1999) Rate of switch from depression into mania after therapeutic sleep deprivation in bipolar depression. Psychiatry Res 86:267–270

    CAS  PubMed  Google Scholar 

  • Colombo C, Lucca A, Benedetti F, Barbini B, Campori E, Smeraldi E (2000) Total sleep deprivation combined with lithium and light therapy in the treatment of bipolar depression: replication of main effects and interaction. Psychiatry Res 95:43–53

    CAS  PubMed  Google Scholar 

  • Davidson RJ, Irwin W, Anderle MJ, Kalin NH (2003) The neural substrates of affective processing in depressed patients treated with venlafaxine. Am J Psychiatry 160:64–75

    PubMed  Google Scholar 

  • Deboer T, Vansteensel MJ, Detari L, Meijer JH (2003) Sleep states alter activity of suprachiasmatic nucleus neurons. Nat Neurosci 6:1086–1090

    CAS  PubMed  Google Scholar 

  • Delva NJ, Woo M, Southmayd SE, Hawken ER (2001) Myocardial infarction during sleep deprivation in a patient with dextrocardia–a case report. Angiology 52:83–86

    CAS  PubMed  Google Scholar 

  • Demet EM, Chicz-Demet A, Fallon JH, Sokolski KN (1999) Sleep deprivation therapy in depressive illness and Parkinson’s disease. Prog Neuropsychopharmacol Biol Psychiatry 23:753–784

    CAS  PubMed  Google Scholar 

  • Ebert D, Feistel H, Kaschka W, Barocka A, Pirner A (1994) Single photon emission computerized tomography assessment of cerebral dopamine D2 receptor blockade in depression before and after sleep deprivation–preliminary results. Biol Psychiatry 35:880–885

    CAS  PubMed  Google Scholar 

  • Ebert D, Albert R, Hammon G, Strasser B, May A, Merz A (1996) Eye-blink rates and depression. Is the antidepressant effect of sleep deprivation mediated by the dopamine system? Neuropsychopharmacology 15:332–339

    CAS  PubMed  Google Scholar 

  • Elliott R, Rubinsztein JS, Sahakian BJ, Dolan RJ (2002) The neural basis of mood-congruent processing biases in depression. Arch Gen Psychiatry 59:597–604

    PubMed  Google Scholar 

  • Fahndrich E (1981) Effects of sleep deprivation on depressed patients of different nosological groups. Psychiatry Res 5:277–285

    CAS  PubMed  Google Scholar 

  • Frye MA, Helleman G, McElroy SL et al (2009) Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression. Am J Psychiatry 166:164–172

    PubMed  Google Scholar 

  • Gardner JP, Fornal CA, Jacobs BL (1997) Effects of sleep deprivation on serotonergic neuronal activity in the dorsal raphe nucleus of the freely moving cat. Neuropsychopharmacology 17:72–81

    CAS  PubMed  Google Scholar 

  • Gerner RH, Post RM, Gillin JC, Bunney WE Jr (1979) Biological and behavioral effects of one night’s sleep deprivation in depressed patients and normals. J Psychiatr Res 15:21–40

    CAS  PubMed  Google Scholar 

  • Gessa GL, Pani L, Fadda P, Fratta W (1995) Sleep deprivation in the rat: an animal model of mania. Eur Neuropsychopharmacol 5(Suppl):89–93

    CAS  PubMed  Google Scholar 

  • Giedke H, Schwarzler F (2002) Therapeutic use of sleep deprivation in depression. Sleep Med Rev 6:361–377

    PubMed  Google Scholar 

  • Giedke H, Wormstall H, Haffner HT (1990) Therapeutic sleep deprivation in depressives, restricted to the two nocturnal hours between 3:00 and 5:00. Prog Neuropsychopharmacol Biol Psychiatry 14:37–47

    CAS  PubMed  Google Scholar 

  • Giedke H, Geilenkirchen R, Hauser M (1992) The timing of partial sleep deprivation in depression. J Affect Disord 25:117–128

    CAS  PubMed  Google Scholar 

  • Grozinger M, Kogel P, Roschke J (2002) Effects of REM sleep awakenings and related wakening paradigms on the ultradian sleep cycle and the symptoms in depression. J Psychiatr Res 36:299–308

    PubMed  Google Scholar 

  • Grunze H, Erfurth A, Walden J (1999) Trimipramine fails to exert antimanic efficacy: a case of the discrepancy between in vitro rationale and clinical efficacy. Clin Neuropharmacol 22:298–300

    CAS  PubMed  Google Scholar 

  • Hamann S (2005) Blue genes: wiring the brain for depression. Nat Neurosci 8:701–703

    CAS  PubMed  Google Scholar 

  • Hanlon EC, Vyazovskiy VV, Faraguna U, Tononi G, Cirelli C (2011) Synaptic potentiation and sleep need: clues from molecular and electrophysiological studies. Curr Top Med Chem 11:2472–2482

    CAS  PubMed  Google Scholar 

  • Harvey AG (2008) Sleep and circadian rhythms in bipolar disorder: seeking synchrony, harmony, and regulation. Am J Psychiatry 165:820–829

    PubMed  Google Scholar 

  • Hefti K, Holst SC, Sovago J et al (2013) Increased metabotropic glutamate receptor subtype 5 availability in human brain after one night without sleep. Biol Psychiatry 73:161–168

    CAS  PubMed  Google Scholar 

  • Heils A, Mossner R, Lesch KP (1997) The human serotonin transporter gene polymorphism–basic research and clinical implications. J Neural Transm 104:1005–1014

    CAS  PubMed  Google Scholar 

  • Hines DJ, Schmitt LI, Hines RM, Moss SJ, Haydon PG (2013) Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling. Transl Psychiatry 3:e212

    PubMed Central  CAS  PubMed  Google Scholar 

  • Hipolide DC, Moreira KM, Barlow KB, Wilson AA, Nobrega JN, Tufik S (2005) Distinct effects of sleep deprivation on binding to norepinephrine and serotonin transporters in rat brain. Prog Neuropsychopharmacol Biol Psychiatry 29:297–303

    CAS  PubMed  Google Scholar 

  • Hogl B, Peralta C, Wetter TC, Gershanik O, Trenkwalder C (2001) Effect of sleep deprivation on motor performance in patients with Parkinson’s disease. Mov Disord 16:616–621

    CAS  PubMed  Google Scholar 

  • Holsboer-Trachsler E, Hemmeter U, Hatzinger M, Seifritz E, Gerhard U, Hobi V (1994) Sleep deprivation and bright light as potential augmenters of antidepressant drug treatment–neurobiological and psychometric assessment of course. J Psychiatr Res 28:381–399

    CAS  PubMed  Google Scholar 

  • Huber R, Maki H, Rosanova M et al (2013) Human cortical excitability increases with time awake. Cereb Cortex 23:332–338

    PubMed Central  PubMed  Google Scholar 

  • Joffe RT, Swinson RP (1988) Total sleep deprivation in patients with obsessive-compulsive disorder. Acta Psychiatr Scand 77:483–487

    CAS  PubMed  Google Scholar 

  • Kasper S, Moises HW, Beckmann H (1983) Dexamethasone suppression test combined with total sleep deprivation in depressed patients. Psychiatr Clin (Basel) 16:17–25

    CAS  Google Scholar 

  • Kasper S, Sack DA, Wehr TA, Kick H, Voll G, Vieira A (1988) Nocturnal TSH and prolactin secretion during sleep deprivation and prediction of antidepressant response in patients with major depression. Biol Psychiatry 24:631–641

    CAS  PubMed  Google Scholar 

  • Kavcic P, Rojc B, Dolenc-Groselj L, Claustrat B, Fujs K, Poljak M (2011) The impact of sleep deprivation and nighttime light exposure on clock gene expression in humans. Croat Med J 52:594–603

    PubMed Central  CAS  PubMed  Google Scholar 

  • Kuhs H, Tolle R (1991) Sleep deprivation therapy. Biol Psychiatry 29:1129–1148

    CAS  PubMed  Google Scholar 

  • Kwok JB, Hallupp M, Loy CT et al (2005) GSK3B polymorphisms alter transcription and splicing in Parkinson’s disease. Ann Neurol 58:829–839

    CAS  PubMed  Google Scholar 

  • Leibenluft E, Wehr TA (1992) Is sleep deprivation useful in the treatment of depression? Am J Psychiatry 149:159–168

    CAS  PubMed  Google Scholar 

  • Lim MM, Xu J, Holtzman DM, Mach RH (2011) Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum. NeuroReport 22:489–493

    PubMed Central  CAS  PubMed  Google Scholar 

  • Lopez-Rodriguez F, Wilson CL, Maidment NT, Poland RE, Engel J (2003) Total sleep deprivation increases extracellular serotonin in the rat hippocampus. Neuroscience 121:523–530

    CAS  PubMed  Google Scholar 

  • Manji HK, Quiroz JA, Payne JL et al (2003) The underlying neurobiology of bipolar disorder. World Psychiatry 2:136–146

    PubMed Central  PubMed  Google Scholar 

  • Martiny K, Refsgaard E, Lund V et al (2013) The day-to-day acute effect of wake therapy in patients with major depression using the HAM-D6 as primary outcome measure: results from a randomised controlled trial. PLoS ONE 8:e67264

    PubMed Central  CAS  PubMed  Google Scholar 

  • Massart R, Freyburger M, Suderman M et al (2014) The genome-wide landscape of DNA methylation and hydroxymethylation in response to sleep deprivation impacts on synaptic plasticity genes. Transl Psychiatry 4:e347

    PubMed Central  CAS  PubMed  Google Scholar 

  • Massimini M, Ferrarelli F, Huber R, Esser SK, Singh H, Tononi G (2005) Breakdown of cortical effective connectivity during sleep. Science 309:2228–2232

    CAS  PubMed  Google Scholar 

  • Matussek N, Romisch P, Ackenheil M (1977) MHPG excretion during sleep deprivation in endogenous depression. Neuropsychobiology 3:23–29

    CAS  PubMed  Google Scholar 

  • Mogilnicka E (1981) REM sleep deprivation changes behavioral response to catecholaminergic and serotonergic receptor activation in rats. Pharmacol Biochem Behav 15:149–151

    CAS  PubMed  Google Scholar 

  • Mongrain V, Hernandez SA, Pradervand S et al (2010) Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis. Sleep 33:1147–1157

    PubMed Central  PubMed  Google Scholar 

  • Mongrain V, La Spada F, Curie T, Franken P (2011) Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex. PLoS ONE 6:e26622

    PubMed Central  CAS  PubMed  Google Scholar 

  • Muller HU, Riemann D, Berger M, Muller WE (1993) The influence of total sleep deprivation on urinary excretion of catecholamine metabolites in major depression. Acta Psychiatr Scand 88:16–20

    CAS  PubMed  Google Scholar 

  • Neumeister A, Goessler R, Lucht M, Kapitany T, Bamas C, Kasper S (1996) Bright light therapy stabilizes the antidepressant effect of partial sleep deprivation. Biol Psychiatry 39:16–21

    CAS  PubMed  Google Scholar 

  • Nissen C, Feige B, Konig A, Voderholzer U, Berger M, Riemann D (2001) Delta sleep ratio as a predictor of sleep deprivation response in major depression. J Psychiatr Res 35:155–163

    CAS  PubMed  Google Scholar 

  • Parry BL, Curran ML, Stuenkel CA et al (2000) Can critically timed sleep deprivation be useful in pregnancy and postpartum depressions? J Affect Disord 60:201–212

    CAS  PubMed  Google Scholar 

  • Payne JL, Quiroz JA, Zarate CA Jr, Manji HK (2002) Timing is everything: does the robust upregulation of noradrenergically regulated plasticity genes underlie the rapid antidepressant effects of sleep deprivation? Biol Psychiatry 52:921–926

    CAS  PubMed  Google Scholar 

  • Peet M (1994) Induction of mania with selective serotonin re-uptake inhibitors and tricyclic antidepressants. Br J Psychiatry 164:549–550

    CAS  PubMed  Google Scholar 

  • Pezawas L, Meyer-Lindenberg A, Drabant EM et al (2005) 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 8:828–834

    CAS  PubMed  Google Scholar 

  • Reinink E, Bouhuys N, Wirz-Justice A, van den Hoofdakker R (1990) Prediction of the antidepressant response to total sleep deprivation by diurnal variation of mood. Psychiatry Res 32:113–124

    CAS  PubMed  Google Scholar 

  • Ridderinkhof KR, Ullsperger M, Crone EA, Nieuwenhuis S (2004) The role of the medial frontal cortex in cognitive control. Science 306:443–447

    CAS  PubMed  Google Scholar 

  • Riemann D, Hohagen F, Konig A et al (1996) Advanced vs. normal sleep timing: effects on depressed mood after response to sleep deprivation in patients with a major depressive disorder. J Affect Disord 37:121–128

    CAS  PubMed  Google Scholar 

  • Riemann D, Konig A, Hohagen F et al (1999) How to preserve the antidepressive effect of sleep deprivation: a comparison of sleep phase advance and sleep phase delay. Eur Arch Psychiatry Clin Neurosci 249:231–237

    CAS  PubMed  Google Scholar 

  • Robbins TW (2005) Controlling stress: how the brain protects itself from depression. Nat Neurosci 8:261–262

    CAS  PubMed  Google Scholar 

  • Roy-Byrne PP, Uhde TW (1984) Post RM antidepressant effect of one night’s sleep deprivation: clinical and theoretical implications. In: Post RM, Ballenger JC (eds) Neurobiology of mood disorders. William & Wilkins, Baltimore, pp 817–835

    Google Scholar 

  • Roy-Byrne PP, Uhde TW, Post RM (1986) Effects of one night’s sleep deprivation on mood and behavior in panic disorder. Patients with panic disorder compared with depressed patients and normal controls. Arch Gen Psychiatry 43:895–899

    CAS  PubMed  Google Scholar 

  • Ruhe HG, Ooteman W, Booij J et al (2009) Serotonin transporter gene promoter polymorphisms modify the association between paroxetine serotonin transporter occupancy and clinical response in major depressive disorder. Pharmacogenet Genomics 19:67–76

    CAS  PubMed  Google Scholar 

  • Salomon RM, Delgado PL, Licinio J, Krystal JH, Heninger GR, Charney DS (1994) Effects of sleep deprivation on serotonin function in depression. Biol Psychiatry 36:840–846

    CAS  PubMed  Google Scholar 

  • Santos R, Carlini EA (1983) Serotonin receptor activation in rats previously deprived of REM sleep. Pharmacol Biochem Behav 18:501–507

    CAS  PubMed  Google Scholar 

  • Savelyev SA, Rantamaki T, Rytkonen KM, Castren E, Porkka-Heiskanen T (2012) Sleep homeostasis and depression: studies with the rat clomipramine model of depression. Neuroscience 212:149–158

    CAS  PubMed  Google Scholar 

  • Schulte W (1971) Zum Priblem der provokation und kupierung von Melancholischen Phasen. Schweizer Arch Neurol Neurochem Psychiatr 109:427–435

    CAS  Google Scholar 

  • Selvi Y, Gulec M, Agargun MY, Besiroglu L (2007) Mood changes after sleep deprivation in morningness-eveningness chronotypes in healthy individuals. J Sleep Res 16:241–244

    PubMed  Google Scholar 

  • Serretti A, Benedetti F, Colombo C, Lilli R, Lorenzi C, Smeraldi E (1999) Dopamine receptor D4 is not associated with antidepressant activity of sleep deprivation. Psychiatry Res 89:107–114

    CAS  PubMed  Google Scholar 

  • Serretti A, Benedetti F, Zanardi R, Smeraldi E (2005) The influence of Serotonin Transporter Promoter Polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments. Prog Neuropsychopharmacol Biol Psychiatry 29(6):1074–1084

    Google Scholar 

  • Siegel JM, Rogawski MA (1988) A function for REM sleep: regulation of noradrenergic receptor sensitivity. Brain Res 472:213–233

    CAS  PubMed  Google Scholar 

  • Smeraldi E, Benedetti F, Barbini B, Campori E, Colombo C (1999) Sustained antidepressant effect of sleep deprivation combined with pindolol in bipolar depression—a placebo-controlled trial. Neuropsychopharmacology 20:380–385

    CAS  PubMed  Google Scholar 

  • Suh SY, Kim JW, Choi CU et al (2007) Spontaneous coronary dissection associated with sleep deprivation presenting with acute myocardial infarction. Int J Cardiol 115:e78–e79

    PubMed  Google Scholar 

  • Sulzer D, Edwards RH (2005) Antidepressants and the monoamine masquerade. Neuron 46:1–2

    CAS  PubMed  Google Scholar 

  • Tononi G, Cirelli C (2003) Sleep and synaptic homeostasis: a hypothesis. Brain Res Bull 62:143–150

    PubMed  Google Scholar 

  • Tononi G, Cirelli C (2006) Sleep function and synaptic homeostasis. Sleep Med Rev 10:49–62

    PubMed  Google Scholar 

  • Tufik S, Lindsey CJ, Carlini EA (1978) Does REM sleep deprivation induce a supersensitivity of dopaminergic receptors in the rat brain? Pharmacology 16:98–105

    CAS  PubMed  Google Scholar 

  • van den Burg W, Bouhuys AL, van den Hoofdakker RH, Beersma DG (1990) Sleep deprivation in bright and dim light: antidepressant effects on major depressive disorder. J Affect Disord 19:109–117

    PubMed  Google Scholar 

  • Vogel GW, Thurmond A, Gibbons P, Sloan K, Walker M (1975) REM sleep reduction effects on depression syndromes. Arch Gen Psychiatry 32:765–777

    CAS  PubMed  Google Scholar 

  • Volkow ND, Wang GJ, Telang F et al (2008) Sleep deprivation decreases binding of [11C]raclopride to dopamine D2/D3 receptors in the human brain. J Neurosci 28:8454–8461

    PubMed Central  CAS  PubMed  Google Scholar 

  • Volkow ND, Tomasi D, Wang GJ et al (2012) Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain. J Neurosci 32:6711–6717

    PubMed Central  CAS  PubMed  Google Scholar 

  • Vyazovskiy VV, Cirelli C, Pfister-Genskow M, Faraguna U, Tononi G (2008) Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep. Nat Neurosci 11:200–208

    CAS  PubMed  Google Scholar 

  • Wehr TA, Rosenthal NE, Sack DA, Gillin JC (1985) Antidepressant effects of sleep deprivation in bright and dim light. Acta Psychiatr Scand 72:161–165

    CAS  PubMed  Google Scholar 

  • Wirz-Justice A, Van den Hoofdakker RH (1999) Sleep deprivation in depression: what do we know, where do we go? Biol Psychiatry 46:445–453

    CAS  PubMed  Google Scholar 

  • Wirz-Justice A, Tobler I, Kafka MS et al (1981) Sleep deprivation: effects on circadian rhythms of rat brain neurotransmitter receptors. Psychiatry Res 5:67–76

    CAS  PubMed  Google Scholar 

  • Wirz-Justice A, Benedetti F, Berger M et al (2005) Chronotherapeutics (light and wake therapy) in affective disorders. Psychol Med 35:939–944

    PubMed  Google Scholar 

  • Wirz-Justice A, Benedetti F, Terman M (2009) Chronotherapeutics for affective disorders. A clinician’s manual for light and wake therapy. Karger, Basel

    Google Scholar 

  • Wu J, Buchsbaum MS, Gillin JC et al (1999) Prediction of antidepressant effects of sleep deprivation by metabolic rates in the ventral anterior cingulate and medial prefrontal cortex. Am J Psychiatry 156:1149–1158

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Neurosciences, Scientific Institute, University Vita-Salute San Raffaele, Milano, Italy

    Sara Dallaspezia & Francesco Benedetti

  2. Dipartimento di Neuroscienze Cliniche, Istituto Scientifico Universitario Ospedale San Raffaele, San Raffaele Turro, Via Stamira d’Ancona 20, 20127, Milano, Italy

    Sara Dallaspezia

Authors
  1. Sara Dallaspezia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Francesco Benedetti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sara Dallaspezia .

Editor information

Editors and Affiliations

  1. Center for Behavior and Neurosciences, University of Groningen, Groningen, The Netherlands

    Peter Meerlo

  2. Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA

    Ruth M. Benca

  3. Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Ted Abel

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Dallaspezia, S., Benedetti, F. (2014). Sleep Deprivation Therapy for Depression. In: Meerlo, P., Benca, R., Abel, T. (eds) Sleep, Neuronal Plasticity and Brain Function. Current Topics in Behavioral Neurosciences, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2014_363

Download citation

Publish with us

Policies and ethics

Search

Navigation