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Behavioral Neurobiology of Chronic Pain pp 101–120Cite as

Preclinical Assessment of Pain: Improving Models in Discovery Research

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Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 20))

Abstract

To date, animal models have not sufficiently “filtered” targets for new analgesics, increasing the failure rate and cost of drug development. Preclinical assessment of “pain” has historically relied on measures of evoked behavioral responses to sensory stimuli in animals. Such measures can often be observed in decerebrated animals and therefore may not sufficiently capture affective and motivational aspects of pain, potentially diminishing translation from preclinical studies to the clinical setting. Further, evidence indicates that there are important mechanistic differences between evoked behavioral responses of hypersensitivity and ongoing pain, limiting evaluation of mechanisms that could mediate aspects of clinically relevant pain. The mechanisms underlying ongoing pain in preclinical models are currently being explored and may serve to inform decisions towards the transition from drug discovery to drug development for a given target.

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Authors and Affiliations

  1. Department of Biomedical Sciences, Center for Excellence in the Neurosciences, College of Osteopathic Medicine, University of New England, Biddeford, ME, 04005, USA

    Tamara King

  2. Department of Pharmacology, University of Arizona Health Sciences Center, College of Medicine, University of Arizona, Tucson, AZ, 85721, USA

    Frank Porreca

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  1. Tamara King
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  2. Frank Porreca
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Correspondence to Tamara King .

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Editors and Affiliations

  1. University of Kentucky Medical Center, Lexington, Kentucky, USA

    Bradley K. Taylor

  2. Centre for Pain Research, National University of Ireland, Galway, Ireland

    David P. Finn

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King, T., Porreca, F. (2014). Preclinical Assessment of Pain: Improving Models in Discovery Research. In: Taylor, B., Finn, D. (eds) Behavioral Neurobiology of Chronic Pain. Current Topics in Behavioral Neurosciences, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2014_330

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