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Zinc Enzyme Inhibitors pp 35–46Cite as

Inhibitors of Histidinol Dehydrogenase

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Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 22))

Abstract

The widespread emergence of resistance and multi-resistance to antibiotics among bacterial pathogens represents a major threat and necessitates a permanent race for finding new molecular targets. Inhibition of enzymes catalyzing particular steps of bacterial amino acid biosynthesis has been considered for several years as a pertinent strategy for drug intervention. Identification of specific inhibitors of the original target histidinol dehydrogenase (HDH, EC 1.1.1.23), the bacterial metalloenzyme responsible for the catalysis of the last step of l-histidine biosynthesis, has opened new opportunities for the development of novel anti-infective agents. This chapter gives an up-to-date overview of the role played by this crucial enzyme in intracellular bacteria and describes the different approaches explored to identify inhibitors of this metalloprotein with potential application as novel antimicrobial drugs.

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Author information

Authors and Affiliations

  1. Centre d’Études d’Agents Pathogènes et Biotechnologies pour la Santé (CPBS), FRE3689, CNRS, Université de Montpellier, 1919 route de Mende, 34293, Montpellier Cedex 5, France

    Stephan Köhler

  2. Chimie et Biologie des Membranes et des Nano-objets (CBMN), CNRS UMR 5248, Université de Bordeaux, Allée Geoffroy de Saint Hilaire, 33600, Pessac, France

    Jean Dessolin

  3. Institut des Biomolécules Max Mousseron (IBMM) UMR 5247 CNRS, ENSCM, Université de Montpellier, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l’Ecole Normale, 34296, Cedex Montpellier, France

    Jean-Yves Winum

Authors
  1. Stephan Köhler
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  2. Jean Dessolin
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  3. Jean-Yves Winum
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Corresponding author

Correspondence to Jean-Yves Winum .

Editor information

Editors and Affiliations

  1. Neurofarba Department, University of Florence, Sesto Fiorentino (Firenze), Italy

    Claudiu T. Supuran

  2. Neurofarba Department, University of Florence, Sesto Fiorentino (Firenze), Italy

    Clemente Capasso

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© 2016 Springer International Publishing Switzerland

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Köhler, S., Dessolin, J., Winum, JY. (2016). Inhibitors of Histidinol Dehydrogenase. In: Supuran, C., Capasso, C. (eds) Zinc Enzyme Inhibitors. Topics in Medicinal Chemistry, vol 22. Springer, Cham. https://doi.org/10.1007/7355_2016_7

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