Abstract
Auxin is an essential regulator of plant growth and development. Polarized transport of auxin is responsible for apical dominance, tropic growth, and organ development. Previous studies have demonstrated that the polarized movement of auxin is dependent upon the action of polarly localized, endocytotically cycled PIN auxin efflux facilitator proteins. More recently, plant orthologs of mammalian multidrug-resistance (MDR)/P-glycoprotein (PGP) type ABC transporters have been shown to function in auxin transport. In this review, the PGP nomenclature/numbering system established by Martinoia et al., (Planta 214:345--355,2002) is used, as there is increasing evidence that in plants MDR/PGPs function as PGPs and not as multiple specificity MDR proteins. Defects in PGP1 and PGP19 (MDR1)genes result in decreased auxin transport and reduced growth phenotypes in Arabidopsis (pgp1, pgp19), maize (br2), and sorghum (dw3). Further, dwarf phenotypes are more severe in Arabidopsis double mutants, indicating that PGPs have overlapping functions. More recently, MDR/PGPs have been shown to function as ATP-activated hydrophobic anion transporters capable of auxin transport. Further, MDR/PGPs have been shown to stabilize PIN1 in detergent-resistant membrane microdomains, and synergistic MDR/PGP-PIN interactions have been shown to increase the rate and specificity of MDR/PGP-mediated auxin transport. Several lines of evidence indicate that, like their mammalian counterparts, Arabidopsis MDR/PGPs are regulated via endocytic cycling. Here we review the evidence for endocytic cycling of MDR/PGPs in planta and provide a model by which this cycling could occur.
Keywords
- Auxin Transport
- Curr Opin Plant Biol
- Auxin Transport Inhibitor
- Auxin Gradient
- Arabidopsis Thaliana Seedling
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Blakeslee, J.J., Peer, W.A., Murphy, A.S. MDR/PGP Auxin Transport Proteins and Endocytic Cycling. In: Šamaj, J., Baluška, F., Menzel, D. (eds) Plant Endocytosis. Plant Cell Monographs, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7089_010
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DOI: https://doi.org/10.1007/7089_010
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