Abstract
In this review, we discuss methanoprolines, which are analogues of proline that contain a bridged methylene group at different positions, which we designate herein as proline methanologues. Particular emphasis is placed on naturally occurring members, general methods for the stereocontrolled synthesis of different diastereoisomers, functionalized analogues, conformational and stereoelectronic features, as well as their utility as proline congeners in medicinally relevant compounds.
Keywords
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We thank CONACyT for a fellowship to Miguel Vilchis and to NSERC for financial support.
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Vilchis-Reyes, M.A., Hanessian, S. (2015). Proline Methanologues: Design, Synthesis, Structural Properties, and Applications in Medicinal Chemistry. In: Lubell, W. (eds) Peptidomimetics I. Topics in Heterocyclic Chemistry, vol 48. Springer, Cham. https://doi.org/10.1007/7081_2015_191
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