Chapter

Synthesis and Modification of Heterocycles by Metal-Catalyzed Cross-coupling Reactions

Volume 45 of the series Topics in Heterocyclic Chemistry pp 61-157

Date:

Metal Catalyzed Cross-Coupling Reactions in the Decoration of Pyrimidine, Pyridazine, and Pyrazine

  • Laurin WimmerAffiliated withInstitute of Applied Synthetic Chemistry, Vienna University of Technology 
  • , Lukas RycekAffiliated withInstitute of Applied Synthetic Chemistry, Vienna University of Technology 
  • , Moumita KoleyAffiliated withDepartment of Organic Chemistry, Indian Institute of Science
  • , Michael SchnürchAffiliated withInstitute of Applied Synthetic Chemistry, Vienna University of Technology Email author 

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Abstract

This chapter treats the cross-coupling chemistry of electron-deficient N-heterocycles containing two nitrogen atoms. The chapter is ordered according to heterocycle, coupling method, and the role of the N-heterocycle within the coupling process. The focus lies on new developments in the field, e.g., regarding new catalytic systems, and covers literature from 2008 until late 2013.

Keywords

Cross-coupling Metal catalysis Palladium Pyrazine Pyridazine Pyrimidine