Abstract
Occurrence of emerging contaminants in environmental waters is directly related to their removal in wastewater treatment plants (WWTP) and the flow rate of the receiving waters. Mediterranean rivers are characterized by important fluctuations in the flow rates and heavy contamination pressures from extensive urban, industrial, and agricultural activities. This translates in contamination levels most often higher than in other European basins. This paper reviews the data regarding the levels of pharmaceuticals and illicit drugs detected in wastewaters and gives an overview of their removal by conventional treatment technologies applying activated sludge. Pharmaceutically active compounds and illicit drugs are selected as two important groups of emerging environmental contaminants that have raised an increasing interest in the scientific community. Their removal in WWTP, the influence of hydrological conditions in the receiving rivers, and dilution factors are described and examples are provided for selected WWTP and rivers in Catalonia (NE Spain).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Céspedes R, Lacorte S, Raldúa D, Ginebreda A, Barceló D, Piña B (2005) Distribution of endocrine disruptors in the Llobregat River basin (Catalonia, NE Spain). Chemosphere 61(11):1710–1719
Huerta-Fontela M, Galcerán MT, Ventura F (2008) Stimulatory drugs of abuse in surface waters and their removal in a conventional drinking water treatment plant. Environ Sci Technol 42(18):6809–6816
NORMAN (2009) – 6th EU framework programme project (Network of reference laboratories and related organisations for monitoring and bio-monitoring of emerging environmental pollutants). http://www.norman-network.net
Kotchen M, Kallaos J, Wheeler K, Wong C, Zahller M (2009) Pharmaceuticals in wastewater: behavior, preferences, and willingness to pay for a disposal program. J Environ Manage 90:1476–1482
Nakada N, Shinohara H, Murata A, Kiri K, Managaki S, Sato N, Takada H (2007) Removal of selected pharmaceuticals and personal care products (PPCPs) and endocrine-disrupting chemicals (EDCs) during sand filtration and ozonation at a municipal sewage treatment plant. Water Res 41:4373–4382
Radjenovic J, Petrovic M, Barcelo D (2007) Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor. Anal Bioanal Chem 387:1365–1377
Santos JL, Aparicio I, Alonso E (2007) Occurrence and risk assessment of pharmaceutically active compounds in wastewater treatment plants. A case study: Seville city (Spain). Environ Int 33:596–601
Gros M, Petrovic M, Barcelo D (2007) Wastewater treatment plants as a pathway for aquatic contamination by pharmaceuticals in the ebro river basin (northeast Spain). Environ Toxicol Chem 26(8):1553–1562
Vieno NM, Tuhkanen T, Kronberg L (2006) Analysis of neutral and basic pharmaceuticals in sewage treatment plants and in recipient rivers using solid phase extraction and liquid chromatography-tandem mass spectrometry detection. J Chromatogr A 1134:101–111
Castiglioni S, Zuccato E, Crisci E, Chiabrando C, Fanelly R, Bagnati R (2006) Identification and measurement of illicit drugs and their metabolites in urban wastewater by liquid chromatography-tandem mass spectrometry. Anal Chem 78:8421–8429
Castiglioni S, Bagnati R, Fanelli R, Pomati F, Calamari D, Zuccato E (2006) Removal of pharmaceuticals in sewage treatment plants in Italy. Environ Sci Technol 40:357–363
Nikolai LN, McClure EL, MacLeod SL, Wong CS (2006) Stereoisomer quantification of the Beta-blocker drugs atenolol, metoprolol, and propranolol in wastewaters by chiral high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr A 1131:103–109
Clara M, Strenn B, Gans O, Martinez E, Kreuzinger N, Kroiss H (2005) Removal of selected pharmaceuticals, fragrances and endocrine disrupting compounds in a membrane bioreactor and conventional wastewater treatment plants. Water Res 39:4797–4807
Watkinson AJ, Murby EJ, Costanzo SD (2007) Removal of antibiotics in conventional and advanced wastewater treatment: Implications for environmental discharge and wastewater recycling. Water Res 41:4164–4176
Jjemba PK (2002) The potential impact of veterinary and human therapeutic agents in manure and biosolids on plants grown on arable land: a review. Agric Ecosyst Environ 93:267–278
Jones OAH, Voulvoulis N, Lester JN (2001) Human pharmaceuticals in the aquatic environment a review. Environ Technol 22:1383–1394
Clara M, Strenn B, Ausserleitner M, Kreuzinger N (2004) Comparison of the behaviour of selected micropollutants in a membrane bioreactor and a conventional wastewater treatment plant. Water Sci Technol 50:29–36
Vieno NM, Tuhkanen T, Kronberg L (2005) Seasonal variation in the occurrence of pharmaceuticals in effluents from a sewage treatment plant and in the recipient water. Environ Sci Technol 39:8220–8226
Gómez MJ, Martínez Bueno MJ, Lacorte S, Fernández-Alba AR, Agüera A (2007) Pilot survey monitoring pharmaceuticals and related compounds in a sewage treatment plant located on the Mediterranean coast. Chemosphere 66:993–1002
Gómez MJ, Agüera A, Mezcua M, Hurtado J, Mocholí F, Fernández-Alba AR (2007) Simultaneous analysis of neutral and acidic pharmaceuticals as well as related compounds by gas chromatography-tandem mass spectrometry in wastewater. Talanta 73:314–320
Lishman L, Smyth SA, Sarafin K, Kleywegt S, Toito J, Peart T, Lee B, Servos M, Beland M, Seto P (2006) Occurrence and reductions of pharmaceuticals and personal care products and estrogens by municipal wastewater treatment plants in Ontario, Canada. Sci Total Environ 367:544–558
Tauxe-Wuersch A, De Alencastro LF, Grandjean D, Tarradellas J (2005) Occurrence of several acidic drugs in sewage treatment plants in Switzerland and risk assessment. Water Res 39:1761–1772
Oleksy-Frenzel J, Wischnack S, Jekel M (2000) Application of ion-chromatography for the determination of the organic-group parameters AOCl, AOBr and AOI in water. Fresenius J Anal Chem 366:89–94
Richardson SD (2008) Environmental mass spectrometry: emerging contaminants and current issues. Anal Chem 80(12):4373–4402
United Nations on Drugs and Crime (UNODC) (2008) World Drug Report 2008
Bijlsma L, Sancho JV, Pitarch E, Ibáñez M, Hernández F (2009) Simultaneous ultra-high-pressure liquid chromatography-tandem mass spectrometry determination of amphetamine and amphetamine-like stimulants, cocaine and its metabolites, and a cannabis metabolite in surface water and urban wastewater. J Chromatogr A 1216(15):3078–3089
Boleda MR, Galcerán MT, Ventura F (2007) Trace determination of cannabinoids and opiates in wastewater and surface waters by ultra-performance liquid chromatography-tandem mass spectrometry. J Chromatogr A 1175:38–48
Bones J, Thomas KV, Paull B (2007) Using environmental analytical data to estimate levels of community consumption of illicit drugs and abused pharmaceuticals. J Environ Monit 9(7):701–707
Chiaia AC, Banta-Green C, Field J (2008) Eliminating solid phase extraction with large-volume injection LC/MS/MS: analysis of illicit and legal drugs and human urine indicators in US wastewaters. Environ Sci Technol 42(23):8841–8848
Gheorghe A, Van Nuijs A, Pecceu B, Bervoets L, Jorens PG, Blust R, Neels H, Covaci A (2008) Analysis of cocaine and its principal metabolites in waste and surface water using solid-phase extraction and liquid chromatography-ion trap tandem mass spectrometry. Anal Bioanal Chem 391(4):1309–1319
Huerta-Fontela M, Galcerán MT, Ventura F (2007) Ultraperformance liquid chromatography-tandem mass spectrometry analysis of stimulatory drugs of abuse in wastewater and surface waters. Anal Chem 79:3821–3829
Hummel D, Löffler D, Fink G, Ternes TA (2006) Simultaneous determination of psychoactive drugs and their metabolites in aqueous matrices by liquid chromatography mass spectrometry. Environ Sci Technol 40:7321–7328
Jones-Lepp TL, Alvarez DA, Petty JD, Huckins JN (2004) Polar organic chemical integrative sampling and liquid chromatography–electrospray/ion-trap mass spectrometry for assessing selected prescription and illicit drugs in treated sewage effluents. Arch Environ Contam Toxicol 47:427–439
Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2008) Multiresidue methods for the analysis of pharmaceuticals, personal care products and illicit drugs in surface water and wastewater by solid-phase extraction and ultra performance liquid chromatography-electrospray tandem mass spectrometry. Anal Bioanal Chem 391(4):1293–1308
Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2009) The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters. Water Res 43(2):363–380
Postigo C, Lopez De Alda MJ, Barcelo D (2008) Fully automated determination in the low nanogram per liter level of different classes of drugs of abuse in sewage water by on-line solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry. Anal Chem 80(9):3123–3134
Zuccato E, Chiabrando C, Castiglioni S, Calamari D, Bagnati R, Schiarea S, Fanelli R (2005) Cocaine in surface water: a new evidence-based tool to monitor community drug abuse. Environ Health 4:1–7
Zuccato E, Castiglioni S, Bagnati R, Chiabrando C, Grassi P, Fanelli R (2008) Illicit drugs, a novel group of environmental contaminants. Water Res 42(4–5):961–968
Fent K, Weston AA, Caminada D (2006) Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76:122–159
Ferrari B, Mons R, Vollat B, Fraysse B, Paxeus N, Lo Giudice R, Pollio A, Garric J (2004) Environmental risk assessment of six human pharmaceuticals: are the current enviornmental risk assessment procedures sufficient for the protection of the aquatic environment? Environ Toxicol Chem 23:1344–1354
Hugget D, Brook B, Peterson B, Foran CM, Schlenk D (2002) Toxicity of selected beta adrenergic receptor-blocking pharmaceuticals (B-blockers) on aquatic organisms. Arch Environ Contam Toxicol 43:229–235
Brooks BW, Foran CM, Richards SM, Weston J, Turner PK, Stanley JK, Solomon KR, Slattery M, LaPoint TW (2003) Aquatic ecotoxicology of luoxetine. Toxicol Lett 142:169–183
Kümmerer K (2004) Pharmaceuticals in the environment, 2nd edn. Springer, Heidelberg
Isidori M, Lavorgna M, Nardelli A, Pascarella L, Parella A (2005) Toxic and genotoxic evaluation of six antibiotics on non-target organisms. Sci Total Environ 346:87–98
Schwaiger J, Ferling H, Mallow U, Wintermayr H, Negele R (2004) Toxic effects of non-steroideal anti-inflammatory drug diclofenac. Part I. Histopathological alterations and bioaccumulation in rainbow trout. Aquat Toxicol 68:141–150
Oaks J, Gilbert M, Virani M, Watson R, Meteyer C, Rideout B, Shivaprasad H, Ahmed S, Chaudhry M, Arshad M, Mahmood S, Ali A, Khan A (2004) Diclofenac residues as the cause of vulture population decline in Pakistan. Nature 427:630–633
Flaherty B, Paxeus N, Lo Giudice R, Pollio A, Garric J (2003) Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac. Ecotoxicol Environ Saf 55:359–370
Thaker PD (2005) Pharmaceutical data elude researchers. Environ Sci Technol 139:193A–194A
Joss A, Keller E, Alder AC, Göbel A, McArdell CS, Ternes T, Siegrist H (2005) Removal of pharmaceuticals and fragrances in biological wastewater treatment. Water Res 39(14): 3139–3152
Quintana JB, Weiss S, Reemtsma T (2005) Pathways and metabolites of microbial degradation of selected acidic pharmaceutical and their occurrence in municipal wastewater treated by a membrane bioreactor. Water Res 39:2654–2664
Ternes TA (1998) Occurrence of drugs in German sewage treatment plants and rivers. Water Res 32:3245–3260
Thomas PM, Foster GD (2005) Tracking acidic pharmaceuticals, caffeine, and triclosan through THE wastewater treatment process. Environ Toxicol Chem 24(1):25–30
Lindqvist N, Tuhkanen T, Kronberg L (2005) Occurrence of acidic pharmaceuticals in raw and treated sewages and in receiving waters. Water Res 39(11):2219–2228
Metcalfe CD, Miao XS, Koenig BG, Struger J (2003) Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower Great Lakes, Canada. Environ Toxicol Chem 222:881–2889
McArdell CS, Molnar E, Suter MJF, Giger W (2003) Occurrence and fate of macrolide antibiotics in wastewater treatment plants and in the Glatt Valley watershed, Switzerland. Environ Sci Technol 37(24):5479–5486
Giger W, Alder AC, Golet EM, Kohler HPE, McArdell CS, Molnar E, Siegrist H, Suter MJF (2003) Occurrence and fate of antibiotics as trace contaminants in wastewaters, sewage sludges, and surface waters. Chimia 59:485–491
Golet EM, Strehler A, Alder AC, Giger W (2002) Determination of fluoroquinolone antibacterial agents in sewage sludge and sludge-treated soil using accelerated solvent extraction followed by solid-phase extraction. Anal Chem 74:5455–5462
Carballa M, Omil F, Lema JM, Llompart M, García-Jares C, Rodríguez I, Gómez M, Ternes T (2004) Behavior of pharmaceuticals, cosmetics and hormones in a sewage treatment plant. Water Res 38:2918–2926
Gobel A, McArdell CS, Joss A, Siegrist H, Giger W (2007) Fate of sulfonamides, macrolides, and trimethoprim in different wastewater treatment technologies. Sci Total Environ 372:361–371
Batt AL, Kim S, Aga DS (2006) Enhanced biodegradation of lopromide and trimethoprim in nitrifying activated sludge. Environ Sci Technol 40:7367–7373
Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2007) Multi-residue method for the determination of basic/neutral pharmaceuticals and illicit drugs in surface water by solid-phase extraction and ultra performance liquid chromatography–positive electrospray ionisation tandem mass spectrometry. J Chromatogr A 1161:132–145
Bartelt-Hunt SL, Snow DD, Damon T, Shockley J, Hoagland K (2009) The occurrence of illicit and therapeutic pharmaceuticals in wastewater effluent and surface waters in Nebraska. Environ Pollut 157(3):786–791
Huerta-Fontela M, Galcerán MT, Martin-Alonso J, Ventura F (2008) Occurrence of psychoactive stimulatory drugs in wastewaters in north-eastern Spain. Sci Total Environ 397(1–3):31–40
Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barber LB, Buxton HT (2002) Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999–2000: a national reconnaissance. Environ Sci Technol 36:1202–1211
Sadezky A, Löffler D, Ternes T (2008) Proposal of an environmental indicator and classification system of pharmaceutical product residues for environmental management KNAPPE project “Knowledge and need assessment on pharmaceutical products in environmental waters”. Contract n° 036864. Deliverable 1.2. http://www.knappe-eu.org/
Schlüsener MP, Löffler D, Ternes T (2008) List of relevant PPs. KNAPPE project knowledge and need assessment on pharmaceutical products in environmental waters. Contract n° 036864. Deliverable 1.1. http://www.knappe-eu.org/
Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2008) The occurrence of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs in surface water in South Wales, UK. Water Res 42(13):3498–3518
Van Nuijs ALN, Pecceu B, Theunis L, Dubois N, Charlier C, Jorens PG, Bervoets L, Blust R, Neels H, Covaci A (2009) Spatial and temporal variations in the occurrence of cocaine and benzoylecgonine in waste- and surface water from Belgium and removal during wastewater treatment. Water Res 43(5):1341–1349
Van Nuijs ALN, Pecceu B, Theunis L, Dubois N, Charlier C, Jorens PG, Bervoets L, Blust R, Neels H, Covaci A (2009) Cocaine and metabolites in waste and surface water across Belgium. Environ Pollut 157(1):123–129
Kasprzyk-Hordern B, Dinsdale RM, Guwy AJ (2009) Illicit drugs and pharmaceuticals in the environment – forensic applications of environmental data, Part 2: Pharmaceuticals as chemical markers of faecal water contamination. Environ Pollut 157(6):1778–1786
Christensen JH, Hewitson B, Busuioc A, Chen A, Gao X, Held I, Jones R,. Kolli RK, Kwon WT, Laprise R, Magaña Rueda V, Mearns L, Menéndez CG, Räisänen J, Rinke A, Sarr A, Whetton P (2007) Regional climate projections. In: Solomon S, Qin D, Manning M, Chen Z, Marquis M, Averyt KB, Tignor M, Miller HL (eds) Climate change 2007: the physical science basis. Contribution of working group I to the fourth assessment report of the intergovernmental panel on climate change. Cambridge University Press, Cambridge, UK
Matthies M, Berding V, Beyer A (2004) Probabilistic uncertainty analysis of the European union system for the evaluation of substances multimedia regional distribution model. Environ Toxicol Chem 3(10):2494–2502
Roberts PH, Thomas KV (2006) The occurrence of selected pharmaceuticals in wastewater effluent and surface waters of the lower Tyne catchment. Sci Total Environ 356:143–153
Togola A, Budzinski H (2008) Multi-residue analysis of pharmaceutical compounds in aqueous samples. J Chromatogr A 1117:150–158
Sedlak DL, Pinkston K, Huang CH (2005) Occurrence survey of pharmaceutically active compounds. Awwa Reserch Foundation, Denver, CO
Martínez Bueno MJM, Agüera A, Gómez MJ, Hernando MD, García JF, Fernández-Alba AR (2007) Application of liquid chromatography/quadrupole-linear ion trap mass spectrometry and time-of-flight mass spectrometry to the determination of pharmaceuticals and related contaminants in wastewaters. Anal Chem 79:9372–9384
Kim SD, Cho J, Kim IS, Vanderford BJ, Snyder SA (2007) Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and waste waters. Water Res 41:1013–1021
Ternes TA (2001) Analytical methods for the determination of pharmaceuticals in aqueous environmental samples. Trends Analyt Chem 20:419–434
Farré M, Ferrer I, Ginebreda A, Figueras M, Olivella L, Tirapu L, Vilanova M, Barceló D (2001) Determination of drugs in surface water and wastewater samples by liquid chromatography-mass spectrometry: methods and preliminary results including toxicity studies with Vibrio fischeri. J Chromatogr A 938:187–197
Castiglioni S, Bagnati R, Calamari D, Fanelli R, Zuccato E (2005) A multiresidue analytical method using solid-phase extraction and high-pressure liquid chromatography tandem mass spectrometry to measure pharmaceuticals of different therapeutic classes in urban wastewaters. J Chromatogr A 1092:206–215
Batt AL, Kostich MS, Lazorchak JM (2008) Analysis of ecologically relevant pharmaceuticals in wastewater and surface water using selective solid-phase extraction and UPLC-MS/MS. Anal Chem 80:5021–5030
Terzić S, Senta I, Ahel M, Gros M, Petrović M, Barceló D, Müller J, Knepper T, Martí I, Ventura F, Jovancić P, Jabucar D (2008) Occurrence and fate of emerging wastewater contaminants in Western Balkan Region. Sci Total Environ 399:66–77
Loganathan B, Phillips M, Mowery H, Jones-Lepp TL (2009) Contamination profiles and mass loadings of macrolide antibiotics and illicit drugs from a small urban wastewater treatment plant. Chemosphere 75(1):70–77
Thomas KV, Hilton MJ (2004) The occurrence of selected human pharmaceutical compounds in UK estuaries. Mar Pollut Bull 49:436–444
Wiegel S, Aulinger A, Brockmeyer R, Harms H, Löffler J, Reincke H, Schmidt R, Stachel B, Von Tämpling W, Wanke A (2004) Pharmaceuticals in the river Elbe and its tributaries. Chemosphere 57:107–126
Heberer T (2002) Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol Lett 131:5–17
Tixier C, Singer HP, Oellers S, Müller SR (2003) Occurrence and fate of carbamazepine, clofibric acid, diclofenac, ibuprofen, ketoprofen, and naproxen in surface waters. Environ Sci Technol 37:1061–1068
Boyd GR, Palmeri JM, Zhang S, Grimm DA (2004) Pharmaceuticals and personal care products (PPCPs) and endocrine disrupting chemicals (EDCs) in stormwater canals and Bayou St. John in New Orleans, Louisiana, USA. Sci Total Environ 333:137–148
Sacher F, Ehmann F, Gabriel S, Graf C, Brauch HJ (2008) Pharmaceutical residues in the river Rhine-results of one-decade monitoring programme. J Environ Monit 10(5):664–670
Moldovan Z (2006) Occurrence of pharmaceuticals and personal care products as micropollutants in rivers from Romania. Chemosphere 64:1808–1817
Batt AL, Aga DS (2005) Simultaneous analysis of multiple-classes of antibiotics by ion trap LC/MS/MS for assessing surface water and groundwater contamination. Anal Chem 77:2940–2947
Zuccato E, Castiglioni S, Fanelli R, Reitano G, Bagnati R, Chiabrando C, Pomati F, Rossetti C, Calamari D (2006) Pharmaceuticals in the environment in Italy: causes, occurrence, effects and control. Environ Sci Pollut Res 13:15–21
Schultz MM, Furlong ET (2008) Trace analysis of antidepressant pharmaceuticals and their select degradates in aquatic matrixes by LC/ESI/MS/MS. Anal Chem 80:1756–1762
Sacher F, Lange FT, Brauch HJ, Blankenhorn I (2001) Pharmaceuticals in groundwaters: analytical methods and results of a monitoring program in Baden-Württemberg, Germany. J Chromatogr A 938:199–210
Ternes TA, Bonerz M, Herrmann N, Teiser B, Andersen HR (2007) Irrigation of treated wastewater in Braunschweig, Germany: an option to remove pharmaceuticals and musk fragrances. Chemosphere 66:894–904
Gros M, Petrovic M, Barceló D (2006) Development of a multi-residue analytical method based on liquid chromatography-tandem mass spectrometry (LC-MS-MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters. Talanta 70(4):678–690
Acknowledgments
This work has been supported by the EU projects MODELKEY (GOCE 511237), AQUATERRA (GOCE 505428), and INNOVA-MED (INCO-2006-517728) and by the Spanish Ministry of Education and Science (CTM2006-26227-E/TECNO, CTM2005-25168-E/TECNO, CTM2007-30524-E, and CGL2007-64551/HID) and reflects the author’s view. Cristina Postigo acknowledges the European Social Fund and AGAUR (Generalitat de Catalunya, Spain) for their economical support through the FI pre-doctoral grant.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag London
About this chapter
Cite this chapter
Petrovic, M. et al. (2009). Occurrence and Fate of Pharmaceuticals and Illicit Drugs Under Water Scarcity. In: Sabater, S., Barceló, D. (eds) Water Scarcity in the Mediterranean. The Handbook of Environmental Chemistry(), vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/698_2009_27
Download citation
DOI: https://doi.org/10.1007/698_2009_27
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-03970-6
Online ISBN: 978-3-642-03971-3
eBook Packages: Earth and Environmental ScienceEarth and Environmental Science (R0)