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Clinical Research and Practice pp 33–42Cite as

Seroprevalence of Bartonella Species in Patients with Ocular Inflammation

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Part of the book series: Advances in Experimental Medicine and Biology ((NR,volume 1020))

Abstract

Bartonella species, vector-borne etiologic agents of many systemic or self-limited infections, are responsible for a widening spectrum of diseases in humans, including inflammatory conditions of the eye. The aim of this study was to determine whether there is any relationship between uveitis and the evidence of Bartonella spp. infection in the serum, ocular fluid, and cataract mass in patients with intraocular inflammation. Polymerase chain reaction (PCR)-based tests and DNA sequencing were performed on surgery-extracted specimens of intraocular fluid and lens mass of 33 patients. Sera from 51 patients and 101 control subjects were tested for the presence of specific antibodies against Bartonella spp. Neither IgM-class antibodies against Bartonella spp. nor Bartonella spp. DNA were detected. A specific IgG-class antibody was found in 33.3% of the patients with uveitis. The rate of positive Bartonella serology was higher among the uveitis patients than that in control subjects. This high rate may in part result from unrecognized indirect mechanisms rather than the immediate presence and multiplication of Bartonella spp. in the eyeball. Nonetheless we believe that screening for Bartonella spp. should become part of the diagnostic workup in uveitis.

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References

  • Atıcı S, Kadayıfcı EK, Karaaslan A, Toper MH, Celikel CA, Soysal A, Bakır M (2014) Atypical presentation of cat-scratch disease in an immunocompetent child with serological and pathological evidence. Case Rep Pediatr 2014:397–437. doi:10.1155/2014/397437

    Google Scholar 

  • Babu K, Murthy GJ (2012) Chikungunya virus iridocyclitis in Fuchs’ heterochromic iridocyclitis. Indian J Ophthalmol 60(1):73–74

    Article  PubMed  PubMed Central  Google Scholar 

  • Blanco Ramos JR, Oteo Revuelta JA, Martínez de Artola V, Ramalle Gómara E, García Pineda A, Ibarra Cucalón V (1998) Seroepidemiology of Bartonella henselae infection in a risk group. Rev Clin Esp 198(12):805–809

    CAS  PubMed  Google Scholar 

  • Boulouis HJ, Chang CC, Henn JB, Kasten RW, Chomel BB (2005) Factors associated with rapid emergence of zoonotic Bartonella infections. Vet Res 36(3):383–410

    Article  PubMed  Google Scholar 

  • Breitschwerdt EB, Kordick DL (2000) Bartonella infection in animals: carriership, reservoir potential, pathogenicity, and zoonotic potential for human infection. Clin Microbiol Rev 13(3):428–438

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carithers HA (1985) Cat scratch disease: an overview based on a study of 1,200 patients. Am J Dis Child 139:1124–1133

    Article  CAS  PubMed  Google Scholar 

  • Chmielewski T, Brydak-Godowska J, Fiecek B, Rorot U, Sędrowicz E, Werenowska M, Kopacz D, Hevelke A, Michniewicz M, Kęcik D, Tylewska-Wierzbanowska S (2014) Bacterial tick-borne diseases caused by Bartonella spp., Borrelia burgdorferi sensu lato, Coxiella burnetii, and Rickettsia spp. among patients with cataract surgery. Med Sci Monit 20:927–931

    Article  PubMed  PubMed Central  Google Scholar 

  • Chomel BB, Boulouis HJ, Maruyama S, Breitschwerdt EB (2006) Bartonella spp. in pets and effect on human health. Emerg Infect Dis 12(3):389–394

    Article  PubMed  PubMed Central  Google Scholar 

  • Cunningham ET Jr, Koehler JE (2000) Ocular bartonellosis. Am J Ophthalmol 130:340–349

    Article  CAS  PubMed  Google Scholar 

  • Dehio C (2005) Bartonella-host-cell interactions and vascular tumour formation. Nat Rev Microbiol 3(8):621–631

    Article  CAS  PubMed  Google Scholar 

  • Drancourt M, Berger P, Terrada C, Bodaghi B, Conrath J, Raoult D, LeHoang P (2008) High prevalence of fastidious bacteria in 1520 cases of uveitis of unknown etiology. Medicine (Baltimore) 87(3):167–176

    Article  Google Scholar 

  • Eiger-Moscovich M, Amer R, Oray M, Tabbara KF, Tugal-Tutkun I, Kramer M (2016) Retinal artery occlusion due to Bartonella henselae infection: a case series. Acta Ophthalmol 94(5):367–370

    Article  Google Scholar 

  • Eskow E, Rao RV, Mordechai E (2001) Concurrent infection of the central nervous system by Borrelia burgdorferi and Bartonella henselae: evidence for a novel tick-borne disease complex. Arch Neurol 58(9):1357–1363

    Article  CAS  PubMed  Google Scholar 

  • Fiecek B, Chmielewski T, Tylewska-Wierzbanowska S (2012) Bartonella spp. infections with particular emphasis on eye diseases. Post Mikrobiol 51(1):47–53. (Article in Polish)

    Google Scholar 

  • Goldstein DA, Mouritsen L, Friedlander S, Tessler HH, Deepak PE (2001) Acute endogenous endophthalmitis due to Bartonella henselae. Clin Infect Dis 33:718–721

    Article  CAS  PubMed  Google Scholar 

  • Harms A, Dehio C (2012) Intruders below the radar: molecular pathogenesis of Bartonella spp. Clin Microbiol Rev 25(1):42–78

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jabs DA, Nussenblatt RB, Rosenbaum JT (2005) Standardization of uveitis nomenclature for reporting clinical data. Results of the first international workshop. Am J Ophthalmol 140(3):509–516

    Article  PubMed  Google Scholar 

  • Jad A, Céline T, Bahram B, Phuc L, Nathalie C (2013) Fuchs’ heterochromic cyclitis: a post-infectious manifestation of ocular toxoplasmosis? Int Ophthalmol 33(2):189–194

    Article  PubMed  Google Scholar 

  • Kaiser PO, Riess T, O’Rourke F, Linke D, Kempf VA (2011) Bartonella spp.: throwing light on uncommon human infections. Int J Med Microbiol 301(1):7–15

    Article  CAS  PubMed  Google Scholar 

  • Kalogeropoulos C, Koumpoulis I, Mentis A, Pappa C, Zafeiropoulos P, Aspiotis M (2011) Bartonella and intraocular inflammation: a series of cases and review of literature. Clin Ophthalmol 5:817–829

    Article  PubMed  PubMed Central  Google Scholar 

  • Kawasaki A, Wilson DL (2003) Mass lesions of the posterior segment associated with Bartonella henselae. Br J Ophthalmol 87(2):248–249

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Koesling J, Aebischer T, Falch C, Schülein R, Dehio C (2001) Cutting edge: antibody-mediated cessation of hemotropic infection by the intraerythrocytic mouse pathogen Bartonella grahamii. J Immunol 167(1):11–14

    Article  CAS  PubMed  Google Scholar 

  • Kongyai N, Sirirungsi W, Pathanapitoon K, Tananuvat N, Kunavisarut P, Leechanachai P, de Groot-Mijnes JD, Rothova A (2012) Viral causes of unexplained anterior uveitis in Thailand. Eye 26(4):529–534

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee RA, Ray M, Kasuga DT, Kumar V, Witherspoon CD, Baddley JW (2015) Ocular bartonellosis in transplant recipients: two case reports and review of the literature. Transpl Infect Dis 17(5):723–727

    Article  CAS  PubMed  Google Scholar 

  • Liu Y, Takusagawa HL, Chen TC, Pasquale LR (2011) Fuchs heterochromic iridocyclitis and the rubella virus. Int Ophthalmol Clin 51(4):1–12

    Article  PubMed  Google Scholar 

  • Mączka I, Tylewska-Wierzbanowska S (2012) Heart disease as a late complications of zoonosis transmitted by a ticks. Post Mikrobiol 51(1):37–45. (Article in Polish)

    Google Scholar 

  • Manousaridis K, Peter S, Mennel S (2015) Cat-scratch-disease-associated macular oedema treated with intravitreal ranibizumab. Acta Ophthalmol 93(2):168–170

    Article  Google Scholar 

  • Mazur-Melewska K, Jończyk-Potoczna K, Mania A, Kemnitz P, Szydłowski J, Służewski W, Figlerowicz M (2015) The significance of Bartonella henselae bacteria for oncological diagnosis in children. Infect Agent Cancer 10:30. doi:10.1186/s13027-015-0025-x

    Article  PubMed  PubMed Central  Google Scholar 

  • Müller A, Reiter M, Schötta AM, Stockinger H, Stanek G (2016) Detection of Bartonella spp. in Ixodes ricinus ticks and Bartonella seroprevalence in human populations. Ticks Tick Borne Dis 7(5):763–767

    Article  PubMed  Google Scholar 

  • Ormerod LD, Dailey JP (1999) Ocular manifestations of cat-scratch disease. Curr Opin Ophthalmol 10:209–216

    Article  CAS  PubMed  Google Scholar 

  • Podsiadły E, Sapiejka E, Dąbrowska-Bień J, Majkowski J, Tylewska-Wierzbanowska S (2009) Diagnostics of cat scratch disease and present methods of bartonellosis recognition – a case report. Pol Merkur Lekarski 26(152):131–135. Article in Polish

    PubMed  Google Scholar 

  • Psarros G, Riddell J 4th, Gandhi T, Kauffman CA, Cinti SK (2012) Bartonella henselae infections in solid organ transplant recipients: report of 5 cases and review of the literature. Medicine (Baltimore) 91(2):111–121

    Article  Google Scholar 

  • Reis C, Cote M, Le Rhun D, Lecuelle B, Levin ML, Vayssier-Taussat M, Bonnet SI (2011) Vector competence of the tick Ixodes ricinus for transmission of Bartonella birtlesii. PLoS Negl Trop Dis 5(5):e1186. doi:10.1371/journal.pntd.0001186

    Article  PubMed  PubMed Central  Google Scholar 

  • Resto-Ruiz S, Burgess A, Anderson BE (2003) The role of the host immune response in pathogenesis of Bartonella henselae. DNA Cell Biol 22(6):431–440

    Article  CAS  PubMed  Google Scholar 

  • Rising T, Fulton N, Vasavada P (2016) Splenorenal manifestations of Bartonella henselae infection in a pediatric patient. Case Rep Radiol 2016:7803832. doi:10.1155/2016/7803832

    PubMed  PubMed Central  Google Scholar 

  • Robert MC, Saab M, Rezende FA (2012) Presumed choroidal neovascularization secondary to Bartonella henselae. Can J Ophthalmol 47(4):e9–e10. doi:10.1016/j.jcjo.2012.03.010

    Article  PubMed  Google Scholar 

  • Rondet B, Sarret C, Lacombe P, Rouveyrol F, Chenel C, Romaszko JP, Labbé A (2012) Neurological symptoms with Bartonella henselae infection: report on 2 pediatric cases. Arch Pediatr 19(8):823–826

    Article  CAS  PubMed  Google Scholar 

  • Sander A, Posselt M, Oberle K, Bredt W (1998) Seroprevalence of antibodies to Bartonella henselae in patients with cat scratch disease and in healthy controls: evaluation and comparison of two commercial serological tests. Clin Diagn Lab Immunol 5(4):486–490

    CAS  PubMed  PubMed Central  Google Scholar 

  • Solley WA, Martin DF, Newman NJ, King R, Callanan DG, Zacchei T, Wallace RT, Parks DJ, Bridges W, Sternberg P Jr (1999) Cat scratch disease: posterior segment manifestations. Ophthalmology 106(8):1546–1553

    Article  CAS  PubMed  Google Scholar 

  • Sytykiewicz H, Karbowiak G, Werszko J, Czerniewicz P, Sprawka I, Mitrus J (2012) Molecular screening for Bartonella henselae and Borrelia burgdorferi sensu lato co-existence within Ixodes ricinus populations in central and eastern parts of Poland. Ann Agric Environ Med 19(3):451–456

    CAS  PubMed  Google Scholar 

  • Szczesny P, Linke D, Ursinus A, Bär K, Schwarz H, Riess TM, Kempf VA, Lupas AN, Martin J, Zeth K (2008) Structure of the head of the Bartonella adhesin BadA. PLoS Pathog 4(8):e1000119. doi:10.1371/journal.ppat.1000119

    Article  PubMed  PubMed Central  Google Scholar 

  • Terrada C, Bodaghi B, Conrath J, Raoult D, Drancourt M (2009) Uveitis: an emerging clinical form of Bartonella infection. Clin Microbiol Infect 15(Suppl 2):132–133

    Article  PubMed  Google Scholar 

  • Truttmann MC, Misselwitz B, Huser S, Hardt WD, Critchley DR, Dehio C (2011) Bartonella henselae engages inside-out and outside-in signaling by integrin β1 and talin1 during invasome-mediated bacterial uptake. J Cell Sci 124:3591–3602

    Article  CAS  PubMed  Google Scholar 

  • Tsuneoka H, Tsukahara M (2006) Analysis of data in 30 patients with cat scratch disease without lymphadenopathy. J Infect Chemother 12(4):224–226

    Article  PubMed  Google Scholar 

  • Wade NK, Levi L, Jones MR, Bhisitkul R, Fine L, Cunningham ET Jr (2000) Optic disk edema associated with peripapillary serous retinal detachment: an early sign of systemic Bartonella henselae infection. Am J Ophthalmol 130(3):327–334

    Article  CAS  PubMed  Google Scholar 

  • Zając V, Wójcik-Fatla A, Dutkiewicz J, Szymańska J (2015) Bartonella henselae in eastern Poland: the relationship between tick infection rates and the serological response of individuals occupationally exposed to tick bites. J Vector Ecol 40(1):75–82

    Article  PubMed  Google Scholar 

  • Zenone T (2011) Systemic Bartonella henselae infection in immunocompetent adult presenting as fever of unknown origin. Case Rep Med 2011:183937. doi:10.1155/2011/183937

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgments

The authors would like to acknowledge the contribution of NIPH-NIH in Warsaw for support of serology tests and PCR.

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

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Authors and Affiliations

  1. Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland

    Joanna Brydak-Godowska, Dorota Kopacz & Dariusz Kęcik

  2. Department of Infectious, Tropical Diseases and Hepatology, Medical University of Warsaw, 37 Wolska Street, 01-201, Warsaw, Poland

    Piotr K. Borkowski

  3. Laboratory of Rickettsiae, Chlamydiae and Spirochetes, National Institute of Public Heath-National Institute of Hygiene, Warsaw, Poland

    Beata Fiecek, Stanisława Tylewska-Wierzbanowska & Tomasz Chmielewski

  4. Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland

    Agata Hevelke

  5. Department-Center for Monitoring and Analyses of Population Health Status, National Institute of Public Health-National Institute of Hygiene, Warsaw, Poland

    Daniel Rabczenko

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  1. Joanna Brydak-Godowska
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  2. Dorota Kopacz
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  3. Piotr K. Borkowski
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  9. Tomasz Chmielewski
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Correspondence to Piotr K. Borkowski .

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  1. Opole Medical School, Opole, Poland

    Mieczyslaw Pokorski

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Brydak-Godowska, J. et al. (2017). Seroprevalence of Bartonella Species in Patients with Ocular Inflammation. In: Pokorski, M. (eds) Clinical Research and Practice. Advances in Experimental Medicine and Biology(), vol 1020. Springer, Cham. https://doi.org/10.1007/5584_2017_19

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