Abstract
Patients with acute lung injury are ventilated by conventional mechanical ventilation (CMV) rather than high-frequency jet ventilation (HFJV). This study estimated the potential usefulness of HFJV in acute lung injury. The issue was addressed by comparing the effects on lung function of CMV and HFJV in two rabbit models of neonatal acute lung injury: repetitive saline lung lavage (LAV) and meconium aspiration syndrome (MAS) induced by intratracheal meconium instillation. The animals were then ventilated with either HFJV or CMV for 4 h. Ventilatory pressures, blood gases, and indexes of gas exchange were assessed. Lung edema formation was expressed as wet-dry lung weight ratio. Both LAV and MAS significantly decreased lung compliance, increased airway resistance, and caused severe hypoxemia, hypercarbia, and acidosis. Although CMV was superior to HFJV at 1 h of ventilation, there were no clinically relevant differences in lung function or edema formation between CMV and LAV in both models of respiratory insufficiency at 4 h of ventilation. We conclude that, HFJV may be used for ventilation in acute non-homogenous lung injury.
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References
Bang JO, Ha SI, Choi IC (2012) The effect of positive-end expiratory pressure on oxygenation during high frequency jet ventilation and conventional mechanical ventilation in the rabbit model of acute lung injury. Kor J Anesthesiol 63:346–352
Baumgart S, Hirschl RB, Butler SZ, Coburn CE, Spitzer AR (1992) Diagnosis-related criteria in the consideration of extracorporeal membrane oxygenation in neonates previously treated with high-frequency jet ventilation. Pediatrics 89:491–494
Brown MK, DiBlasi RM (2011) Mechanical ventilation of the premature neonate. Respir Care 56:1298–1311
Calkovska A, Sevecova-Mokra D, Javorka K, Petraskova M, Adamicova K (2005) Exogenous surfactant administration by asymmetric high-frequency jet ventilation in experimental respiratory distress syndrome. Croat Med J 46:209–217
Carlo WA, Chatburn RL, Martin RJ, Lough MD, Shivpuri CR, Anderson JV, Fanaroff AA (1984) Decrease in airway pressure during high-frequency jet ventilation in infants with respiratory distress syndrome. J Pediatr 104:101–107
Carlo WA, Beoglos A, Chatburn RL, Walsh MC, Martin RJ (1989) High-frequency jet ventilation in neonatal pulmonary hypertension. Am J Dis Child 143:233–238
Chowdhury O, Greenough A (2011) Neonatal ventilatory techniques – which are best for infants born at term? Arch Med Sci 7:381–387
Dargaville PA (2012) Respiratory support in meconium aspiration syndrome: a practical guide. Int J Pediatr 2012:965159
Davis JM, Richter SE, Kendig JW, Notter RH (1992) High-frequency jet ventilation and surfactant treatment of newborns with severe respiratory failure. Pediatr Pulmonol 13:108–112
Dushianthan A, Grocott MP, Postle AD, Cusack R (2011) Acute respiratory distress syndrome and acute lung injury. Postgrad Med J 87:612–622
Engle WA, Yoder MC, Andreoli SP, Darragh RK, Langefeld CD, Hui SL (1997) Controlled prospective randomized comparison of high-frequency jet ventilation and conventional ventilation in neonates with respiratory failure and persistent pulmonary hypertension. J Perinatol 17:3–9
Friedlich P, Subramanian N, Sebald M, Noori S, Seri I (2003) Use of high-frequency jet ventilation in neonates with hypoxemia refractory to high-frequency oscillatory ventilation. J Matern Fetal Neonatal Med 13:398–402
Greenough A, Peacock J, Zivanovic S, Alcazar-Paris M, Lo J, Marlow N, Calvert S (2014) United Kingdom Oscillation Study: long-term outcomes of a randomised trial of two modes of neonatal ventilation. Health Technol Assess 18:1–95
Gu XL, Wu GN, Yao YW, Shi DH, Song Y (2014) Is high-frequency oscillatory ventilation more effective and safer than conventional protective ventilation in adult acute respiratory distress syndrome patients? A meta-analysis of randomized controlled trials. Crit Care 18:R111
Keszler M, Modanlou HD, Brudno DS, Clark FI, Cohen RS, Ryan RM, Kaneta MK, Davis JM (1997) Multicenter controlled clinical trial of high-frequency jet ventilation in preterm infants with uncomplicated respiratory distress syndrome. Pediatrics 100:593–599
Maitra S, Bhattacharjee S, Khanna P, Baidya DK (2015) high-frequency ventilation does not provide mortality benefit in comparison with conventional lung-protective ventilation in acute respiratory distress syndrome: a meta-analysis of the randomized controlled trials. Anesthesiology 122:841–851
Mammel MC, Gordon MJ, Connett JE, Boros SJ (1983) Comparison of high-frequency jet ventilation and conventional mechanical ventilation in a meconium aspiration model. J Pediatr 103:630–634
Mikolka P, Mokra D, Kopincova J, Tomcikova-Mikusiakova L, Calkovska A (2013) Budesonide added to modified porcine surfactant Curosurf may additionally improve the lung functions in meconium aspiration syndrome. Physiol Res 62(Suppl 1):S191–S200
Mokra D, Mokry J, Drgova A, Petraskova M, Bulikova J, Calkovska A (2007) Intratracheally administered corticosteroids improve lung function in meconium-instilled rabbits. J Physiol Pharmacol 58(Suppl 5):389–398
Pagani G, Rezzonico R, Marini A (1985) Trials of high frequency jet ventilation in preterm infants with severe respiratory disease. Acta Paediatr Scand 74:681–686
Sevecova D, Calkovska A, Drgova A, Javorka M, Petraskova M, Javorka K (2003) Lung lavage using high-frequency jet ventilation in rabbits with meconium aspiration. Acta Paediatr 92:314–319
Sevecova-Mokra D, Calkovska A, Drgova A, Javorka M, Javorka K (2004) Treatment of experimental meconium aspiration syndrome with surfactant lung lavage and conventional vs. asymmetric high-frequency jet ventilation. Pediatr Pulmonol 38:285–291
Sud S, Sud M, Friedrich JO, Wunsch H, Meade MO, Ferguson ND, Adhikari NK (2013) High-frequency ventilation versus conventional ventilation for treatment of acute lung injury and acute respiratory distress syndrome. Cochrane Database Syst Rev 2:CD004085
Trindade O, Goldberg RN, Bancalari E, Dickstein P, Ellison J, Gerhardt T (1985) Conventional vs. high-frequency jet ventilation in a piglet model of meconium aspiration: comparison of pulmonary and hemodynamic effects. J Pediatr 107:115–120
Wiswell TE, Foster NH, Slayter MV, Hachey WE (1992) Management of a piglet model of the meconium aspiration syndrome with high-frequency or conventional ventilation. Am J Dis Child 146:1287–1293
Acknowledgements
We thank M. Petraskova, M. Hutko, D. Kuliskova, and Z. Remisova for technical assistance. This work was supported in part by grants BioMed (ITMS 26220220187), APVV-0435-11 and VEGA 1/0305/14.
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The authors declare no conflict of interest in relation to this article.
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Mokra, D. et al. (2016). High-Frequency Jet Ventilation against Small-Volume Conventional Mechanical Ventilation in the Rabbit Models of Neonatal Acute Lung Injury. In: Pokorski, M. (eds) Prospect in Pediatric Diseases Medicine. Advances in Experimental Medicine and Biology(), vol 912. Springer, Cham. https://doi.org/10.1007/5584_2016_230
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DOI: https://doi.org/10.1007/5584_2016_230
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